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Streptomycin 3''-kinase (EC 2.7.1.87) (Streptomycin 3''-phosphotransferase) (Streptomycin 6-kinase) (Streptomycin 6-phosphotransferase)

 APHE_STRGR              Reviewed;         272 AA.
P18150;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 1.
22-NOV-2017, entry version 74.
RecName: Full=Streptomycin 3''-kinase;
EC=2.7.1.87;
AltName: Full=Streptomycin 3''-phosphotransferase;
AltName: Full=Streptomycin 6-kinase;
AltName: Full=Streptomycin 6-phosphotransferase;
Name=aphE;
Streptomyces griseus.
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
Streptomyces.
NCBI_TaxID=1911;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 12475 / U-76;
PubMed=2167474; DOI=10.1093/nar/18.15.4615;
Trower M.K., Clark K.G.;
"PCR cloning of a streptomycin phosphotransferase (aphE) gene from
Streptomyces griseus ATCC 12475.";
Nucleic Acids Res. 18:4615-4615(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=N2-3-11;
PubMed=2844130; DOI=10.1007/BF00425160;
Heinzel P., Werbitzky O., Distler J., Piepersberg W.;
"A second streptomycin resistance gene from Streptomyces griseus codes
for streptomycin-3''-phosphotransferase. Relationships between
antibiotic and protein kinases.";
Arch. Microbiol. 150:184-192(1988).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2821169; DOI=10.1099/00221287-133-5-1289;
Shinkawa H., Sugiyama M., Nimi O.;
"The nucleotide sequence of a streptomycin streptomycin
phosphotransferase (streptomycin kinase) gene from a streptomycin
producer.";
J. Gen. Microbiol. 133:1289-1296(1987).
[4]
ERRATUM.
Shinkawa H., Sugiyama M., Nimi O.;
J. Gen. Microbiol. 134:1391-1394(1988).
-!- FUNCTION: The aminoglycoside phosphotransferases achieve
inactivation of their antibiotic substrates by phosphorylation.
-!- CATALYTIC ACTIVITY: ATP + streptomycin = ADP + streptomycin 3''-
phosphate.
-!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase
family. {ECO:0000305}.
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EMBL; X53527; CAA37605.1; -; Genomic_DNA.
EMBL; M37378; AAA26700.1; -; Genomic_DNA.
EMBL; M16482; AAA26815.1; -; Genomic_DNA.
PIR; A46563; A46563.
PIR; JL0031; JL0031.
RefSeq; WP_063840676.1; NG_047409.1.
RefSeq; WP_063840677.1; NG_047410.1.
ProteinModelPortal; P18150; -.
SMR; P18150; -.
KEGG; ag:AAA26815; -.
eggNOG; ENOG4108R0M; Bacteria.
eggNOG; COG3231; LUCA.
KO; K10673; -.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0050299; F:streptomycin 3''-kinase activity; IEA:UniProtKB-EC.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
CDD; cd05150; APH; 1.
InterPro; IPR002575; Aminoglycoside_PTrfase.
InterPro; IPR024165; Kan/Strep_kinase.
InterPro; IPR011009; Kinase-like_dom_sf.
Pfam; PF01636; APH; 1.
PIRSF; PIRSF000706; Kanamycin_kin; 1.
SUPFAM; SSF56112; SSF56112; 1.
3: Inferred from homology;
Antibiotic resistance; ATP-binding; Kinase; Nucleotide-binding;
Transferase.
CHAIN 1 272 Streptomycin 3''-kinase.
/FTId=PRO_0000204801.
ACT_SITE 190 190 Proton acceptor. {ECO:0000250}.
CONFLICT 51 51 A -> P (in Ref. 2; AAA26700).
{ECO:0000305}.
CONFLICT 160 160 V -> A (in Ref. 2; AAA26700).
{ECO:0000305}.
SEQUENCE 272 AA; 29060 MW; 71151C15DDA0E392 CRC64;
MSDHPGPGAV TPELFGVGGD WLAVTAGESG ASVFRAADAT RYAKCVPAAD AAGLEAERDR
IAWLSGQGVP GPRVLDWYAG DAGACLVTRA VPGVPADRVG ADDLRTAWGA VADAVRRLHE
VPVASCPFRR GLDSVVDAAR DVVARGAVHP EFLPVEQRLV PPAELLARLT GELARRRDQE
AADTVVCHGD LCLPNIVLHP ETLEVSGFID LGRLGAADRH ADLALLLANA RETWVDEERA
RFADAAFAER YGIAPDPERL RFYLHLDPLT WG


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