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Streptomycin 6-kinase (EC 2.7.1.72) (APH(6)) (Streptidine kinase) (Streptomycin 6-phosphotransferase)

 STRA_STRGR              Reviewed;         307 AA.
P08077;
01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
01-AUG-1988, sequence version 1.
22-NOV-2017, entry version 72.
RecName: Full=Streptomycin 6-kinase;
EC=2.7.1.72;
AltName: Full=APH(6);
AltName: Full=Streptidine kinase;
AltName: Full=Streptomycin 6-phosphotransferase;
Name=aphD; Synonyms=sph, strA;
Streptomyces griseus.
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
Streptomyces.
NCBI_TaxID=1911;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=N2-3-11;
PubMed=3118332; DOI=10.1093/nar/15.19.8041;
Distler J., Ebert A., Mansouri K., Pissowotzki K., Stockmann M.,
Piepersberg W.;
"Gene cluster for streptomycin biosynthesis in Streptomyces griseus:
nucleotide sequence of three genes and analysis of transcriptional
activity.";
Nucleic Acids Res. 15:8041-8056(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 23345 / DSM 40236 / JCM 4644 / NBRC 12875 / NCIMB 13023 /
NRRL B-2682 / VKM Ac-800;
PubMed=3029728; DOI=10.1093/nar/15.4.1819;
Tohyama H., Okami Y., Umezawa H.;
"Nucleotide sequence of the streptomycinphosphotransferase and
amidinotransferase genes from Streptomyces griseus.";
Nucleic Acids Res. 15:1819-1833(1987).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3039306; DOI=10.1007/BF00330443;
Distler J., Braun C., Ebert A., Piepersberg W.;
"Gene cluster for streptomycin biosynthesis in Streptomyces griseus:
analysis of a central region including the major resistance gene.";
Mol. Gen. Genet. 208:204-210(1987).
-!- FUNCTION: The aminoglycoside phosphotransferases achieve
inactivation of their antibiotic substrates by phosphorylation.
-!- CATALYTIC ACTIVITY: ATP + streptomycin = ADP + streptomycin 6-
phosphate.
-!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase
family. {ECO:0000305}.
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EMBL; Y00459; CAA68516.1; -; Genomic_DNA.
EMBL; X05045; CAA28717.1; -; Genomic_DNA.
EMBL; X05647; CAA29134.1; -; Genomic_DNA.
PIR; A26674; A26674.
PIR; S06355; KISM6G.
RefSeq; WP_063842181.1; NG_047458.1.
ProteinModelPortal; P08077; -.
eggNOG; ENOG4105NFX; Bacteria.
eggNOG; ENOG4111NWB; LUCA.
BioCyc; MetaCyc:MONOMER-14016; -.
GO; GO:0050300; F:aminoglycoside 6-kinase activity; IEA:UniProtKB-EC.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
GO; GO:0019748; P:secondary metabolic process; IEA:InterPro.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR006748; NH2Glyco/OHUrea_AB-resist_kin.
Pfam; PF04655; APH_6_hur; 1.
SUPFAM; SSF56112; SSF56112; 1.
3: Inferred from homology;
Antibiotic resistance; ATP-binding; Kinase; Nucleotide-binding;
Transferase.
CHAIN 1 307 Streptomycin 6-kinase.
/FTId=PRO_0000204815.
REGION 133 145 Aminoglycoside binding. {ECO:0000250}.
ACT_SITE 201 201 Proton acceptor. {ECO:0000250}.
VARIANT 34 39 ALVARC -> GSRRAI (in strain: ISP 5236).
VARIANT 115 120 DGSRTL -> GRFADV (in strain: ISP 5236).
VARIANT 181 188 GWASAVAE -> AVGVGREP (in strain: ISP
5236).
VARIANT 225 225 G -> A (in strain: ISP 5236).
VARIANT 262 262 S -> A (in strain: ISP 5236).
SEQUENCE 307 AA; 33244 MW; 382DFD60DF4028AA CRC64;
MSSSDHIHVP DGLAESYSRS GGEEGRAWIA GLPALVARCV DRWELKRDGG VRSGEASLVV
PVLRADGTRA ALKLQMPREE TTAALIGLRA WGGDGMVRLL DHDEESSTML LERLDGSRTL
ASVEDDDEAM GVLAGLLNRL HSVPAPPGLR GLGEIAGAMV EEVPSAVDSL ADPEDRSRLR
GWASAVAELV GEPGDRVLHW DLHYENVLAA EREPWLAIDP EPLVGDPGFD LWPALDTGWE
RIEATGDARR VVRRRFDLLT ESLELDRGRA AGWTLARLLQ NTLWDIEDGL TAIAPSQIAV
AEALAKP


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