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Streptomycin-6-phosphate phosphatase (EC 3.1.3.39)

 STRK_STRGR              Reviewed;         449 AA.
P09401;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 2.
22-NOV-2017, entry version 91.
RecName: Full=Streptomycin-6-phosphate phosphatase;
EC=3.1.3.39;
Flags: Precursor;
Name=strK;
Streptomyces griseus.
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
Streptomyces.
NCBI_TaxID=1911;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=N2-3-11;
PubMed=1654502; DOI=10.1007/BF00260640;
Mansouri K., Piepersberg W.;
"Genetics of streptomycin production in Streptomyces griseus:
nucleotide sequence of five genes, strFGHIK, including a phosphatase
gene.";
Mol. Gen. Genet. 228:459-469(1991).
-!- FUNCTION: Specifically cleaves both streptomycin-6-phosphate and,
more slowly, streptomycin-3''-phosphate during the biosynthesis of
streptomycin.
-!- CATALYTIC ACTIVITY: Streptomycin 6-phosphate + H(2)O =
streptomycin + phosphate.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Note=Binds 1 Mg(2+) ion. {ECO:0000250};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Binds 2 Zn(2+) ions. {ECO:0000250};
-!- PATHWAY: Antibiotic biosynthesis; streptomycin biosynthesis.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the alkaline phosphatase family.
{ECO:0000305}.
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EMBL; Y00459; CAA68522.1; -; Genomic_DNA.
PIR; S17780; S17780.
RefSeq; WP_003970245.1; NZ_MDDK01000534.1.
ProteinModelPortal; P09401; -.
SMR; P09401; -.
GeneID; 6209972; -.
eggNOG; ENOG4105G6Z; Bacteria.
eggNOG; COG1785; LUCA.
BioCyc; MetaCyc:MONOMER-14015; -.
UniPathway; UPA00066; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0050301; F:streptomycin-6-phosphatase activity; IEA:UniProtKB-EC.
GO; GO:0019872; P:streptomycin biosynthetic process; IEA:UniProtKB-UniPathway.
CDD; cd16012; ALP; 1.
Gene3D; 3.40.720.10; -; 1.
InterPro; IPR017849; Alkaline_Pase-like_a/b/a.
InterPro; IPR001952; Alkaline_phosphatase.
InterPro; IPR018299; Alkaline_phosphatase_AS.
InterPro; IPR017850; Alkaline_phosphatase_core_sf.
PANTHER; PTHR11596; PTHR11596; 2.
Pfam; PF00245; Alk_phosphatase; 2.
PRINTS; PR00113; ALKPHPHTASE.
SMART; SM00098; alkPPc; 1.
SUPFAM; SSF53649; SSF53649; 1.
PROSITE; PS00123; ALKALINE_PHOSPHATASE; 1.
3: Inferred from homology;
Antibiotic biosynthesis; Hydrolase; Magnesium; Metal-binding;
Phosphoprotein; Secreted; Signal; Streptomycin biosynthesis; Zinc.
SIGNAL 1 32 {ECO:0000255}.
CHAIN 33 449 Streptomycin-6-phosphate phosphatase.
/FTId=PRO_0000024016.
ACT_SITE 99 99 Phosphoserine intermediate.
{ECO:0000255|PROSITE-ProRule:PRU10042}.
METAL 50 50 Magnesium. {ECO:0000250}.
METAL 50 50 Zinc 2. {ECO:0000250}.
METAL 151 151 Magnesium. {ECO:0000250}.
METAL 153 153 Magnesium. {ECO:0000250}.
METAL 321 321 Magnesium. {ECO:0000250}.
METAL 326 326 Zinc 1. {ECO:0000250}.
METAL 330 330 Zinc 1. {ECO:0000250}.
METAL 368 368 Zinc 2. {ECO:0000250}.
METAL 369 369 Zinc 2. {ECO:0000250}.
METAL 412 412 Zinc 1. {ECO:0000250}.
SEQUENCE 449 AA; 46343 MW; 2B7BC9393F9686E8 CRC64;
MRFAYGRLPW RRGAVLGSAL LVLVTAPAAS TATERSGPAP ARSVILLIGD GMGDAEITAA
RNYSVGAAGR LAMDTLDASG RRTTYAVDER GRPVYVTDSA AGATAWATGR RTVNGRVSKS
HDTDRPMPTL LELARDRGYA TGSVTTASVA DATPAALTAH VTDRSCKGPA DMAACPADTR
AGGGEGSIAE QTVAARPDVL LGGGADHFAQ TVTDGPFRGR TVTQQARAAG YQVVRDRTQL
AAARPGRPVL GLFAPEYVPV EWTGPPAAPG GTAPQRCATR NPGRPAGTPD LAESTRAALD
LLTARAHHRG APGRGFFLQV EGASIDDRAH EADPCGQLGE TLAFDRAVAA ALDHAERHPR
TLVIVTADHG HATQILPHDA RPAGLSATLV TDEGGVMQLG YGTALPGETQ EHTGVPVPVA
ARGPLADRVR GVQDNTSLFG TVTAALGLR


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