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Stress-activated protein kinase JNK-1 (EC 2.7.11.24)

 JNK1_ANCCA              Reviewed;         376 AA.
Q9U6D2;
30-APR-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 2.
22-NOV-2017, entry version 83.
RecName: Full=Stress-activated protein kinase JNK-1;
EC=2.7.11.24;
Name=JNK-1;
Ancylostoma caninum (Dog hookworm).
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Strongylida; Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae;
Ancylostoma.
NCBI_TaxID=29170 {ECO:0000312|EMBL:AAF00539.1};
[1] {ECO:0000312|EMBL:AAF00539.1}
NUCLEOTIDE SEQUENCE [MRNA].
Arasu P.;
"JNK-1 kinase of the hookworm nematode, Ancylostoma caninum.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Responds to activation by environmental stress and pro-
inflammatory cytokines by phosphorylating a number of
transcription factors, and thus regulates transcriptional
activity. {ECO:0000250|UniProtKB:P45983}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000250|UniProtKB:P45983};
-!- ENZYME REGULATION: Activated by threonine and tyrosine
phosphorylation. {ECO:0000250|UniProtKB:P45983}.
-!- DOMAIN: The TXY motif contains the threonine and tyrosine residues
whose phosphorylation activates the MAP kinases.
-!- PTM: Dually phosphorylated on Thr-183 and Tyr-185, which activates
the enzyme. {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
Ser/Thr protein kinase family. MAP kinase subfamily.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAF00539.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AF187690; AAF00539.1; ALT_INIT; mRNA.
ProteinModelPortal; Q9U6D2; -.
SMR; Q9U6D2; -.
PRIDE; Q9U6D2; -.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004707; F:MAP kinase activity; IEA:UniProtKB-EC.
GO; GO:0007254; P:JNK cascade; ISS:UniProtKB.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR003527; MAP_kinase_CS.
InterPro; IPR008351; MAPK_JNK.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
PRINTS; PR01772; JNKMAPKINASE.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS01351; MAPK; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 376 Stress-activated protein kinase JNK-1.
/FTId=PRO_0000186269.
DOMAIN 26 321 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 33 38 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOTIF 183 185 TXY.
ACT_SITE 151 151 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 55 55 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 183 183 Phosphothreonine. {ECO:0000250}.
MOD_RES 185 185 Phosphotyrosine. {ECO:0000250}.
SEQUENCE 376 AA; 42770 MW; 2EDFA15CC28AD3A4 CRC64;
MASTSVPENY YVVPIGETQM VILKRYENLR LIGSGAQGIV CAATDMVTNK PVAIKKLSRP
FQNVTHAKRA YREFILMNLV NHKNIIGLLN AFSPQREVEE FNDLYIVMEL MDANLCQVIQ
MDLDHERLSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAVEAF
MMTPYVVTRY YRAPEVILGM GYGENVDVWS VGCIFGELIR GRVLFPGADH IDQWTRIIEL
LGTPEPQFLA RLQTTVRNYV ENRQKYQPVP FETLFADNMF PPGADNARLT AAKARDLLSR
MLVIDPEKRI SVDDALAHEY VNVWYDASRG SCSSAGPSTI LLVDGEHTVE EWRAMLFAEL
QNYYRTHDVY GVGQRR


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