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Striatin-interacting protein 1 (Protein FAM40A)

 STRP1_MOUSE             Reviewed;         837 AA.
Q8C079; Q80T92; Q8BZC6; Q8CIF7;
19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
19-JUL-2005, sequence version 2.
28-MAR-2018, entry version 118.
RecName: Full=Striatin-interacting protein 1;
AltName: Full=Protein FAM40A;
Name=Strip1; Synonyms=Fam40a, Kiaa1761;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6J; TISSUE=Medulla oblongata;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
STRAIN=FVB/N; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-837 (ISOFORM 3).
PubMed=12693553; DOI=10.1093/dnares/10.1.35;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
Nakajima D., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene:
II. The complete nucleotide sequences of 400 mouse KIAA-homologous
cDNAs identified by screening of terminal sequences of cDNA clones
randomly sampled from size-fractionated libraries.";
DNA Res. 10:35-48(2003).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic brain;
PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200;
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
"Phosphoproteomic analysis of the developing mouse brain.";
Mol. Cell. Proteomics 3:1093-1101(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain cortex;
PubMed=17114649; DOI=10.1074/mcp.M600046-MCP200;
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,
Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,
Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
"Qualitative and quantitative analyses of protein phosphorylation in
naive and stimulated mouse synaptosomal preparations.";
Mol. Cell. Proteomics 6:283-293(2007).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[7]
IDENTIFICATION IN THE STRIATIN-INTERACTING PHOSPHATASE AND KINASE
(STRIPAK) COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=18782753; DOI=10.1074/mcp.M800266-MCP200;
Goudreault M., D'Ambrosio L.M., Kean M.J., Mullin M.J., Larsen B.G.,
Sanchez A., Chaudhry S., Chen G.I., Sicheri F., Nesvizhskii A.I.,
Aebersold R., Raught B., Gingras A.C.;
"A PP2A phosphatase high density interaction network identifies a
novel striatin-interacting phosphatase and kinase complex linked to
the cerebral cavernous malformation 3 (CCM3) protein.";
Mol. Cell. Proteomics 8:157-171(2009).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
"Large scale localization of protein phosphorylation by use of
electron capture dissociation mass spectrometry.";
Mol. Cell. Proteomics 8:904-912(2009).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-339, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Plays a role in the regulation of cell morphology and
cytoskeletal organization. Required in the cortical actin filament
dynamics and cell shape (By similarity). {ECO:0000250}.
-!- SUBUNIT: Component of striatin-interacting phosphatase and kinase
(STRIPAK) complex (PubMed:18782753). Interacts with CDC42BPB.
Interacts with CTTNBP2NL. {ECO:0000250|UniProtKB:Q5VSL9,
ECO:0000269|PubMed:18782753}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Enriched on
the plasma membrane. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1;
IsoId=Q8C079-1; Sequence=Displayed;
Name=2;
IsoId=Q8C079-2; Sequence=VSP_014865;
Note=No experimental confirmation available. Ref.1 (BAC29206)
sequence differs from that shown due to several frameshifts.
{ECO:0000305};
Name=3;
IsoId=Q8C079-3; Sequence=VSP_014866;
Note=No experimental confirmation available.;
Name=4;
IsoId=Q8C079-4; Sequence=VSP_014863;
Note=No experimental confirmation available.;
-!- SIMILARITY: Belongs to the STRIP family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AK032065; BAC27678.1; -; mRNA.
EMBL; AK035833; BAC29206.1; ALT_FRAME; mRNA.
EMBL; BC023952; AAH23952.1; -; mRNA.
EMBL; AK122553; BAC65835.1; -; Unassigned_RNA.
CCDS; CCDS51043.1; -. [Q8C079-1]
RefSeq; NP_705791.2; NM_153563.2. [Q8C079-1]
UniGene; Mm.278643; -.
ProteinModelPortal; Q8C079; -.
BioGrid; 230890; 15.
CORUM; Q8C079; -.
IntAct; Q8C079; 15.
STRING; 10090.ENSMUSP00000068587; -.
iPTMnet; Q8C079; -.
PhosphoSitePlus; Q8C079; -.
EPD; Q8C079; -.
PaxDb; Q8C079; -.
PeptideAtlas; Q8C079; -.
PRIDE; Q8C079; -.
Ensembl; ENSMUST00000064759; ENSMUSP00000068587; ENSMUSG00000014601. [Q8C079-1]
GeneID; 229707; -.
KEGG; mmu:229707; -.
UCSC; uc008qxg.2; mouse. [Q8C079-1]
CTD; 85369; -.
MGI; MGI:2443884; Strip1.
eggNOG; KOG3680; Eukaryota.
eggNOG; ENOG410XRAB; LUCA.
GeneTree; ENSGT00400000022095; -.
HOGENOM; HOG000252963; -.
HOVERGEN; HBG081506; -.
InParanoid; Q8C079; -.
OMA; NNSFEQD; -.
OrthoDB; EOG091G02GC; -.
PhylomeDB; Q8C079; -.
TreeFam; TF314205; -.
ChiTaRS; Strip1; mouse.
PRO; PR:Q8C079; -.
Proteomes; UP000000589; Chromosome 3.
Bgee; ENSMUSG00000014601; -.
Genevisible; Q8C079; MM.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO; GO:0017048; F:Rho GTPase binding; IPI:UniProtKB.
GO; GO:0030866; P:cortical actin cytoskeleton organization; ISS:UniProtKB.
GO; GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
InterPro; IPR021819; Far11/STRP_C.
InterPro; IPR012486; Far11/STRP_N.
Pfam; PF11882; DUF3402; 2.
Pfam; PF07923; N1221; 1.
SMART; SM01293; DUF3402; 1.
SMART; SM01292; N1221; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Complete proteome; Cytoplasm;
Phosphoprotein; Reference proteome.
CHAIN 1 837 Striatin-interacting protein 1.
/FTId=PRO_0000187019.
COMPBIAS 3 36 Pro-rich.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:Q5VSL9}.
MOD_RES 59 59 Phosphoserine.
{ECO:0000250|UniProtKB:Q5VSL9}.
MOD_RES 335 335 Phosphoserine.
{ECO:0000244|PubMed:15345747,
ECO:0000244|PubMed:19131326,
ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079}.
MOD_RES 339 339 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 788 788 Phosphoserine.
{ECO:0000250|UniProtKB:Q5VSL9}.
VAR_SEQ 1 126 Missing (in isoform 4).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_014863.
VAR_SEQ 430 837 Missing (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_014865.
VAR_SEQ 555 629 Missing (in isoform 3).
{ECO:0000303|PubMed:12693553}.
/FTId=VSP_014866.
CONFLICT 104 104 D -> A (in Ref. 1; BAC27678).
{ECO:0000305}.
CONFLICT 347 347 Q -> H (in Ref. 1; BAC27678).
{ECO:0000305}.
SEQUENCE 837 AA; 95585 MW; BD984594F049D3F4 CRC64;
MEPAAAGPGP LIVNNKQPQP PPPPPPATAQ PPPGAPRAAG GLLPGGKARE FNRNQRKDSE
GYSESPDLEF EYADTDKWAA ELAELYSYTE GPEFLMNRKC FEEDFRIHVS DKKWTELDTN
QHRTHAMRLL DGLEVTAREK RLKVARAILY VAQGTFGECS SEAEVQFWMR YNIFLLLEVG
TFNALVELLN MEIDNSAACS SAVRKPAISL ADSTDLRVLL NIMYLIVETV HQDCDGDKAE
WRTMRQTFRA ELGSPLYNNE PFAIMLFGMV TKFCSGHAPH FPMKKVLLLL WKTVLCTLGG
FEELQSMKAE KRTLLGLPPL PEDSIKVIRN MRAASPPASA SDLIEQQQKR GRREHKALIK
QDNLDAFNER DPYKADDSRE EEEENDDDSS LEGEAFPLER DEVMPPPLQH PQTDRLTCPK
GLPWAPKVRE KDIEMFLESS RSKFIGYTLG SDTNTVVGLP RPIHESIKTL KQHKYTSIAE
VQAQMEEEYL RSPLSGGEEE VEQVPAETLY QGLLPSLPQY MIALLKILLA AAPTSKAKTD
SINILADVLP EEMPTTVLQS MKLGVDVNRH KEVIVKAISA VLLLLLKHFK LNHIYQFEYM
AQHLVFANCI PLILKFFNQN IMSYITAKNS ISVLDYPHCV VNELPELTAE SLEAGDNNQF
CWRNLFSCIN LLRILNKLTK WKHSRTMMLV VFKSAPILKR ALKVKQAMMQ LYVLKLLKVQ
TKYLGRQWRK SNMKTMSAIY QKVRHRLNDD WAYGNDLDAR PWDFQAEECA LRANIERFNA
RRYDRTHSNP DFLPVDNCLQ SVLGQRVDLP EDFQMNYDLW LEREVFSKPI SWEELLQ


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