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Structure-specific endonuclease subunit SLX1 (EC 3.1.-.-) (Synthetic lethal of unknown function protein 1)

 SLX1_YEAST              Reviewed;         304 AA.
P38324; D6VQM3;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 1.
25-OCT-2017, entry version 127.
RecName: Full=Structure-specific endonuclease subunit SLX1 {ECO:0000255|HAMAP-Rule:MF_03100};
EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_03100};
AltName: Full=Synthetic lethal of unknown function protein 1;
Name=SLX1 {ECO:0000255|HAMAP-Rule:MF_03100};
OrderedLocusNames=YBR228W; ORFNames=YBR1525;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=7813418;
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J.,
Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C.,
Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M.,
Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L.,
Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J.,
Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T.,
Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A.,
Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B.,
Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I.,
Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M.,
Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A.,
van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I.,
Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H.,
Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.;
"Complete DNA sequence of yeast chromosome II.";
EMBO J. 13:5795-5809(1994).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[3]
FUNCTION, AND INTERACTION WITH SLX4.
PubMed=11139495;
Mullen J.R., Kaliraman V., Ibrahim S.S., Brill S.J.;
"Requirement for three novel protein complexes in the absence of the
Sgs1 DNA helicase in Saccharomyces cerevisiae.";
Genetics 157:103-118(2001).
[4]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=12832395; DOI=10.1101/gad.1105203;
Fricke W.M., Brill S.J.;
"Slx1-Slx4 is a second structure-specific endonuclease functionally
redundant with Sgs1-Top3.";
Genes Dev. 17:1768-1778(2003).
-!- FUNCTION: Catalytic subunit of the SLX1-SLX4 structure-specific
endonuclease that resolves DNA secondary structures generated
during DNA repair and recombination. Has endonuclease activity
towards branched DNA substrates, introducing single-strand cuts in
duplex DNA close to junctions with ss-DNA. Has a preference for
simple Y, 5'-flap and replication fork-like structures. It cleaves
the strand bearing the 5'-non-homologous arm at the branch site
junction and generates ligatable, nicked products from the 5'-flap
or replication fork substrates. Plays a critical role in
maintaining the integrity of the ribosomal DNA (rDNA) loci, where
it has a role in re-starting stalled replication forks. Has
Holliday junction resolvase activity in vitro. {ECO:0000255|HAMAP-
Rule:MF_03100, ECO:0000269|PubMed:11139495,
ECO:0000269|PubMed:12832395}.
-!- COFACTOR:
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
Evidence={ECO:0000255|HAMAP-Rule:MF_03100};
-!- SUBUNIT: Forms a heterodimer with SLX4.
-!- INTERACTION:
Q12098:SLX4; NbExp=4; IntAct=EBI-21016, EBI-37788;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03100,
ECO:0000269|PubMed:12832395}.
-!- SIMILARITY: Belongs to the SLX1 family. {ECO:0000255|HAMAP-
Rule:MF_03100}.
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EMBL; Z36097; CAA85191.1; -; Genomic_DNA.
EMBL; BK006936; DAA07343.1; -; Genomic_DNA.
PIR; S46104; S46104.
RefSeq; NP_009787.3; NM_001178576.3.
ProteinModelPortal; P38324; -.
SMR; P38324; -.
BioGrid; 32923; 91.
DIP; DIP-1770N; -.
IntAct; P38324; 3.
MINT; MINT-402886; -.
STRING; 4932.YBR228W; -.
PRIDE; P38324; -.
EnsemblFungi; YBR228W; YBR228W; YBR228W.
GeneID; 852529; -.
KEGG; sce:YBR228W; -.
EuPathDB; FungiDB:YBR228W; -.
SGD; S000000432; SLX1.
GeneTree; ENSGT00390000013368; -.
HOGENOM; HOG000248775; -.
InParanoid; P38324; -.
KO; K15078; -.
OMA; CCYLLQS; -.
OrthoDB; EOG092C2PJV; -.
BioCyc; YEAST:G3O-29161-MONOMER; -.
PRO; PR:P38324; -.
Proteomes; UP000002311; Chromosome II.
GO; GO:0005634; C:nucleus; IC:SGD.
GO; GO:0033557; C:Slx1-Slx4 complex; IPI:SGD.
GO; GO:0017108; F:5'-flap endonuclease activity; IDA:SGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO; GO:0006261; P:DNA-dependent DNA replication; IGI:SGD.
Gene3D; 3.40.1440.10; -; 1.
HAMAP; MF_03100; Endonuc_su_Slx1; 1.
InterPro; IPR000305; GIY-YIG_endonuc.
InterPro; IPR035901; GIY-YIG_endonuc_sf.
InterPro; IPR027520; Slx1.
Pfam; PF01541; GIY-YIG; 1.
SMART; SM00465; GIYc; 1.
SUPFAM; SSF82771; SSF82771; 1.
PROSITE; PS50164; GIY_YIG; 1.
1: Evidence at protein level;
Complete proteome; DNA damage; DNA recombination; DNA repair;
Endonuclease; Hydrolase; Metal-binding; Nuclease; Nucleus;
Reference proteome; Zinc; Zinc-finger.
CHAIN 1 304 Structure-specific endonuclease subunit
SLX1.
/FTId=PRO_0000202517.
DOMAIN 12 95 GIY-YIG. {ECO:0000255|HAMAP-
Rule:MF_03100}.
ZN_FING 218 282 SLX1-type. {ECO:0000255|HAMAP-
Rule:MF_03100}.
SEQUENCE 304 AA; 35857 MW; 4C676E877FDF7A7A CRC64;
MSQKIQQHQF PDFYCCYLLQ SINKRQSFYV GSTPNPVRRL RQHNGKLAVG GAYRTKRDGS
RPWEMIMIVR GFPSKIAALQ FEHAWQHGYQ THYIAEKDRV VKHKAGGRTL HHKVALMKLL
LKHEFFQRMN LIVEVFNIKA WEVWKQDKFF IERDRFPINI QINENALEEP KEKTVDVLMD
HSDENLKVVE AVYTKVIENE RNIFETFEKK LTTGVVRCEI CEKEIDYTSE EQNLKPFVAL
CNNKDCGCVN HLKCLHRYFL DDEQLMVGRR NLIPRGGKCP KCDMFCDWTT LVKFSTRMKL
AHGK


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