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Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2)

 NK2R_RAT                Reviewed;         390 AA.
P16610;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
01-AUG-1990, sequence version 1.
22-NOV-2017, entry version 126.
RecName: Full=Substance-K receptor;
Short=SKR;
AltName: Full=NK-2 receptor;
Short=NK-2R;
AltName: Full=Neurokinin A receptor;
AltName: Full=Tachykinin receptor 2;
Name=Tacr2; Synonyms=Tac2r;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2480781; DOI=10.1016/S0006-291X(89)80022-1;
Sasai Y., Nakanishi S.;
"Molecular characterization of rat substance K receptor and its
mRNAs.";
Biochem. Biophys. Res. Commun. 165:695-702(1989).
-!- FUNCTION: This is a receptor for the tachykinin neuropeptide
substance K (neurokinin A). It is associated with G proteins that
activate a phosphatidylinositol-calcium second messenger system.
The rank order of affinity of this receptor to tachykinins is:
substance K > neuromedin-K > substance P.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; M31838; AAA42150.1; -; mRNA.
PIR; A36737; A36737.
RefSeq; NP_542946.1; NM_080768.1.
UniGene; Rn.202846; -.
ProteinModelPortal; P16610; -.
STRING; 10116.ENSRNOP00000067266; -.
ChEMBL; CHEMBL4554; -.
GuidetoPHARMACOLOGY; 361; -.
iPTMnet; P16610; -.
PhosphoSitePlus; P16610; -.
PaxDb; P16610; -.
Ensembl; ENSRNOT00000071394; ENSRNOP00000067266; ENSRNOG00000050658.
GeneID; 25007; -.
KEGG; rno:25007; -.
CTD; 6865; -.
RGD; 3812; Tacr2.
eggNOG; KOG4219; Eukaryota.
eggNOG; ENOG410XSC5; LUCA.
GeneTree; ENSGT00900000140861; -.
HOVERGEN; HBG103412; -.
InParanoid; P16610; -.
KO; K04223; -.
OMA; CMAAFNA; -.
OrthoDB; EOG091G0WYG; -.
PhylomeDB; P16610; -.
Reactome; R-RNO-380095; Tachykinin receptors bind tachykinins.
Reactome; R-RNO-416476; G alpha (q) signalling events.
PRO; PR:P16610; -.
Proteomes; UP000002494; Chromosome 20.
Bgee; ENSRNOG00000050658; -.
Genevisible; P16610; RN.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0061827; C:sperm head; IEA:Ensembl.
GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
GO; GO:0016497; F:substance K receptor activity; IDA:RGD.
GO; GO:0014827; P:intestine smooth muscle contraction; IMP:RGD.
GO; GO:0033685; P:negative regulation of luteinizing hormone secretion; IMP:RGD.
GO; GO:0035106; P:operant conditioning; IMP:RGD.
GO; GO:0014057; P:positive regulation of acetylcholine secretion, neurotransmission; IMP:RGD.
GO; GO:1902093; P:positive regulation of flagellated sperm motility; IEA:Ensembl.
GO; GO:0043270; P:positive regulation of ion transport; IMP:RGD.
GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; IDA:RGD.
GO; GO:0043117; P:positive regulation of vascular permeability; IMP:RGD.
GO; GO:0070459; P:prolactin secretion; IMP:RGD.
GO; GO:0070472; P:regulation of uterine smooth muscle contraction; ISO:RGD.
GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
CDD; cd16004; 7tmA_SKR_NK2R; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR001681; Neurokn_rcpt.
InterPro; IPR000913; NK2_rcpt.
PANTHER; PTHR43919:SF4; PTHR43919:SF4; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01025; NEUROKININ2R.
PRINTS; PR00244; NEUROKININR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
Palmitate; Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 390 Substance-K receptor.
/FTId=PRO_0000069897.
TOPO_DOM 1 32 Extracellular. {ECO:0000255}.
TRANSMEM 33 56 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 57 69 Cytoplasmic. {ECO:0000255}.
TRANSMEM 70 90 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 91 107 Extracellular. {ECO:0000255}.
TRANSMEM 108 129 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 130 149 Cytoplasmic. {ECO:0000255}.
TRANSMEM 150 170 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 171 196 Extracellular. {ECO:0000255}.
TRANSMEM 197 218 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 219 251 Cytoplasmic. {ECO:0000255}.
TRANSMEM 252 272 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 273 290 Extracellular. {ECO:0000255}.
TRANSMEM 291 310 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 311 390 Cytoplasmic. {ECO:0000255}.
LIPID 324 324 S-palmitoyl cysteine. {ECO:0000255}.
CARBOHYD 19 19 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 106 181 {ECO:0000255|PROSITE-ProRule:PRU00521}.
SEQUENCE 390 AA; 43853 MW; A6C4FF70194726DB CRC64;
MGTRAIVSDA NILSGLESNA TGVTAFSMPG WQLALWATAY LALVLVAVTG NATVIWIILA
HERMRTVTNY FIINLALADL CMAAFNATFN FIYASHNIWY FGRAFCYFQN LFPITAMFVS
IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA IIAGIWLVAL ALASPQCFYS TITVDEGATK
CVVAWPNDNG GKMLLLYHLV VFVLIYFLPL LVMFGAYSVI GLTLWKRAVP RHQAHGANLR
HLQAKKKFVK AMVLVVLTFA ICWLPYHLYF ILGTFQEDIY YHKFIQQVYL ALFWLAMSST
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TEEDRLELTH TPSLSRRVNR CHTKETLFMT
GDMTHSEATN GQVGSPQDGE PAGPICKAQA


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