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Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)

 NK1R_RAT                Reviewed;         407 AA.
P14600;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 1.
25-OCT-2017, entry version 140.
RecName: Full=Substance-P receptor;
Short=SPR;
AltName: Full=NK-1 receptor;
Short=NK-1R;
AltName: Full=Tachykinin receptor 1;
Name=Tacr1; Synonyms=Tac1r;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1705552;
Hershey A.D., Dykema P.E., Krause J.E.;
"Organization, structure, and expression of the gene encoding the rat
substance P receptor.";
J. Biol. Chem. 266:4366-4374(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2478537;
Yokota Y., Sasai Y., Tanaka K., Fujiwara T., Tsuchida K.,
Shigemoto R., Kakizuka A., Ohkubo H., Nakanishi S.;
"Molecular characterization of a functional cDNA for rat substance P
receptor.";
J. Biol. Chem. 264:17649-17652(1989).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Sprague-Dawley;
PubMed=2154852; DOI=10.1126/science.2154852;
Hershey A.D., Krause J.E.;
"Molecular characterization of a functional cDNA encoding the rat
substance P receptor.";
Science 247:958-962(1990).
[4]
SEQUENCE REVISION TO 213.
Hershey A.D.;
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: This is a receptor for the tachykinin neuropeptide
substance P. It is probably associated with G proteins that
activate a phosphatidylinositol-calcium second messenger system.
The rank order of affinity of this receptor to tachykinins is:
substance P > substance K > neuromedin-K.
-!- SUBUNIT: Interacts with ARRB1.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; M64236; AAA42176.1; -; Genomic_DNA.
EMBL; M64232; AAA42176.1; JOINED; Genomic_DNA.
EMBL; M64233; AAA42176.1; JOINED; Genomic_DNA.
EMBL; M64234; AAA42176.1; JOINED; Genomic_DNA.
EMBL; M64235; AAA42176.1; JOINED; Genomic_DNA.
EMBL; J05097; AAA42175.1; -; mRNA.
EMBL; M31477; AAB59726.1; -; mRNA.
PIR; A38692; A34357.
RefSeq; NP_036799.1; NM_012667.2.
UniGene; Rn.89609; -.
ProteinModelPortal; P14600; -.
BioGrid; 246930; 1.
MINT; MINT-1510212; -.
STRING; 10116.ENSRNOP00000007984; -.
BindingDB; P14600; -.
ChEMBL; CHEMBL4027; -.
GuidetoPHARMACOLOGY; 360; -.
PhosphoSitePlus; P14600; -.
PaxDb; P14600; -.
PRIDE; P14600; -.
Ensembl; ENSRNOT00000007984; ENSRNOP00000007984; ENSRNOG00000005853.
GeneID; 24807; -.
KEGG; rno:24807; -.
UCSC; RGD:3811; rat.
CTD; 6869; -.
RGD; 3811; Tacr1.
eggNOG; KOG4219; Eukaryota.
eggNOG; ENOG410XSC5; LUCA.
GeneTree; ENSGT00900000140861; -.
HOGENOM; HOG000013018; -.
HOVERGEN; HBG103412; -.
InParanoid; P14600; -.
KO; K04222; -.
OMA; MIIVVCT; -.
OrthoDB; EOG091G0WYG; -.
PhylomeDB; P14600; -.
TreeFam; TF315303; -.
Reactome; R-RNO-380095; Tachykinin receptors bind tachykinins.
Reactome; R-RNO-416476; G alpha (q) signalling events.
PRO; PR:P14600; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000005853; -.
Genevisible; P14600; RN.
GO; GO:0044297; C:cell body; IDA:RGD.
GO; GO:0009986; C:cell surface; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0016496; F:substance P receptor activity; IDA:RGD.
GO; GO:0002526; P:acute inflammatory response; IEP:RGD.
GO; GO:0002118; P:aggressive behavior; IMP:RGD.
GO; GO:0003051; P:angiotensin-mediated drinking behavior; IMP:RGD.
GO; GO:0008306; P:associative learning; IMP:RGD.
GO; GO:0048266; P:behavioral response to pain; IMP:RGD.
GO; GO:0042755; P:eating behavior; IMP:RGD.
GO; GO:0007611; P:learning or memory; IMP:RGD.
GO; GO:0007616; P:long-term memory; IMP:RGD.
GO; GO:0007218; P:neuropeptide signaling pathway; TAS:RGD.
GO; GO:0035106; P:operant conditioning; IMP:RGD.
GO; GO:0045760; P:positive regulation of action potential; IMP:RGD.
GO; GO:0045777; P:positive regulation of blood pressure; IMP:RGD.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IMP:RGD.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:RGD.
GO; GO:0046887; P:positive regulation of hormone secretion; IMP:RGD.
GO; GO:0002687; P:positive regulation of leukocyte migration; IMP:RGD.
GO; GO:0050671; P:positive regulation of lymphocyte proliferation; IMP:RGD.
GO; GO:0045778; P:positive regulation of ossification; IMP:RGD.
GO; GO:0035815; P:positive regulation of renal sodium excretion; IMP:RGD.
GO; GO:0046878; P:positive regulation of saliva secretion; IMP:RGD.
GO; GO:0051496; P:positive regulation of stress fiber assembly; IMP:RGD.
GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IMP:RGD.
GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IMP:RGD.
GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; IDA:RGD.
GO; GO:0043117; P:positive regulation of vascular permeability; IMP:RGD.
GO; GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.
GO; GO:0008217; P:regulation of blood pressure; IMP:RGD.
GO; GO:0014910; P:regulation of smooth muscle cell migration; IMP:RGD.
GO; GO:0048660; P:regulation of smooth muscle cell proliferation; IMP:RGD.
GO; GO:0010996; P:response to auditory stimulus; IDA:RGD.
GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0045471; P:response to ethanol; IMP:RGD.
GO; GO:0009408; P:response to heat; IMP:RGD.
GO; GO:0009725; P:response to hormone; IMP:RGD.
GO; GO:0043278; P:response to morphine; IEP:RGD.
GO; GO:0035094; P:response to nicotine; IMP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IDA:RGD.
GO; GO:0010193; P:response to ozone; IMP:RGD.
GO; GO:0032570; P:response to progesterone; IEP:RGD.
GO; GO:0019233; P:sensory perception of pain; IMP:RGD.
GO; GO:0060083; P:smooth muscle contraction involved in micturition; IMP:RGD.
GO; GO:0042713; P:sperm ejaculation; IMP:RGD.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR001681; Neurokn_rcpt.
InterPro; IPR000046; NK1_rcpt.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01024; NEUROKININ1R.
PRINTS; PR00244; NEUROKININR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
Palmitate; Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 407 Substance-P receptor.
/FTId=PRO_0000069888.
TOPO_DOM 1 31 Extracellular. {ECO:0000255}.
TRANSMEM 32 54 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 55 64 Cytoplasmic. {ECO:0000255}.
TRANSMEM 65 86 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 87 106 Extracellular. {ECO:0000255}.
TRANSMEM 107 128 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 129 148 Cytoplasmic. {ECO:0000255}.
TRANSMEM 149 169 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 170 194 Extracellular. {ECO:0000255}.
TRANSMEM 195 219 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 220 248 Cytoplasmic. {ECO:0000255}.
TRANSMEM 249 270 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 271 283 Extracellular. {ECO:0000255}.
TRANSMEM 284 308 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 309 407 Cytoplasmic. {ECO:0000255}.
LIPID 322 322 S-palmitoyl cysteine. {ECO:0000255}.
CARBOHYD 14 14 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 18 18 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 105 180 {ECO:0000255|PROSITE-ProRule:PRU00521}.
CONFLICT 73 73 N -> D (in Ref. 3; AAB59726).
{ECO:0000305}.
SEQUENCE 407 AA; 46366 MW; ADF885A0BF551C96 CRC64;
MDNVLPMDSD LFPNISTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN VVVIWIILAH
KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY GLFYCKFHNF FPIAALFASI
YSMTAVAFDR YMAIIHPLQP RLSATATKVV IFVIWVLALL LAFPQGYYST TETMPSRVVC
MIEWPEHPNR TYEKAYHICV TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV
SAKRKVVKMM IVVVCTFAIC WLPFHVFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK VSRLETTIST
VVGAHEEEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS FYSNMLA


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