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Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit 2 of complex II) (FP)

 SDHA2_ARATH             Reviewed;         632 AA.
Q9ZPX5;
25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
25-APR-2018, entry version 128.
RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial;
EC=1.3.5.1 {ECO:0000250|UniProtKB:P31040};
AltName: Full=Flavoprotein subunit 2 of complex II;
Short=FP;
Flags: Precursor;
Name=SDH1-2; OrderedLocusNames=At2g18450; ORFNames=T30D6.4;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=11910074; DOI=10.1126/science.1071006;
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
Shibata K., Shinagawa A., Shinozaki K.;
"Functional annotation of a full-length Arabidopsis cDNA collection.";
Science 296:141-145(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
TISSUE SPECIFICITY.
PubMed=12374303; DOI=10.1023/A:1019926301981;
Figueroa P., Leon G., Elorza A., Holuigue L., Araya A., Jordana X.;
"The four subunits of mitochondrial respiratory complex II are encoded
by multiple nuclear genes and targeted to mitochondria in Arabidopsis
thaliana.";
Plant Mol. Biol. 50:725-734(2002).
[6]
IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE
SCALE ANALYSIS].
STRAIN=cv. Landsberg erecta;
PubMed=14671022; DOI=10.1105/tpc.016055;
Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J.,
Millar A.H.;
"Experimental analysis of the Arabidopsis mitochondrial proteome
highlights signaling and regulatory components, provides assessment of
targeting prediction programs, and indicates plant-specific
mitochondrial proteins.";
Plant Cell 16:241-256(2004).
[7]
IDENTIFICATION BY MASS SPECTROMETRY, AND SUBUNIT.
PubMed=15604729; DOI=10.1007/s11103-004-2316-2;
Millar A.H., Eubel H., Jansch L., Kruft V., Heazlewood J.L.,
Braun H.P.;
"Mitochondrial cytochrome c oxidase and succinate dehydrogenase
complexes contain plant specific subunits.";
Plant Mol. Biol. 56:77-90(2004).
-!- FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase
(SDH) that is involved in complex II of the mitochondrial electron
transport chain and is responsible for transferring electrons from
succinate to ubiquinone (coenzyme Q).
{ECO:0000250|UniProtKB:P31040}.
-!- CATALYTIC ACTIVITY: Succinate + a quinone = fumarate + a quinol.
{ECO:0000250|UniProtKB:P31040}.
-!- COFACTOR:
Name=FAD; Xref=ChEBI:CHEBI:57692;
Evidence={ECO:0000250|UniProtKB:Q0QF01};
-!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
fumarate from succinate (eukaryal route): step 1/1.
{ECO:0000250|UniProtKB:P31040}.
-!- SUBUNIT: Component of complex II composed of eight subunits in
plants: four classical SDH subunits SDH1, SDH2, SDH3 and SDH4 (a
flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b
composed of a large and a small subunit.), as well as four
subunits unknown in mitochondria from bacteria and heterotrophic
eukaryotes. {ECO:0000269|PubMed:15604729}.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
{ECO:0000269|PubMed:14671022}; Peripheral membrane protein
{ECO:0000269|PubMed:14671022}; Matrix side
{ECO:0000269|PubMed:14671022}.
-!- TISSUE SPECIFICITY: Expressed at a low level.
{ECO:0000269|PubMed:12374303}.
-!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family.
FRD/SDH subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AC006439; AAD15493.1; -; Genomic_DNA.
EMBL; CP002685; AEC06769.1; -; Genomic_DNA.
EMBL; AK119142; BAC43712.1; -; mRNA.
EMBL; BT005938; AAO64873.1; -; mRNA.
PIR; D84564; D84564.
RefSeq; NP_179435.1; NM_127401.3.
UniGene; At.39995; -.
ProteinModelPortal; Q9ZPX5; -.
SMR; Q9ZPX5; -.
STRING; 3702.AT2G18450.1; -.
PaxDb; Q9ZPX5; -.
PRIDE; Q9ZPX5; -.
EnsemblPlants; AT2G18450.1; AT2G18450.1; AT2G18450.
GeneID; 816359; -.
Gramene; AT2G18450.1; AT2G18450.1; AT2G18450.
KEGG; ath:AT2G18450; -.
Araport; AT2G18450; -.
TAIR; locus:2062146; AT2G18450.
eggNOG; KOG2403; Eukaryota.
eggNOG; COG1053; LUCA.
HOGENOM; HOG000160475; -.
InParanoid; Q9ZPX5; -.
KO; K00234; -.
OMA; SRSMNME; -.
OrthoDB; EOG093604YT; -.
PhylomeDB; Q9ZPX5; -.
UniPathway; UPA00223; UER01006.
PRO; PR:Q9ZPX5; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; Q9ZPX5; baseline and differential.
Genevisible; Q9ZPX5; AT.
GO; GO:0005749; C:mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); ISS:TAIR.
GO; GO:0005739; C:mitochondrion; IDA:TAIR.
GO; GO:0045273; C:respiratory chain complex II; IDA:UniProtKB.
GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
GO; GO:0000104; F:succinate dehydrogenase activity; TAS:TAIR.
GO; GO:0009061; P:anaerobic respiration; IBA:GO_Central.
GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; TAS:TAIR.
GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
Gene3D; 3.50.50.60; -; 2.
Gene3D; 3.90.700.10; -; 1.
InterPro; IPR003953; FAD-binding_2.
InterPro; IPR036188; FAD/NAD-bd_sf.
InterPro; IPR003952; FRD_SDH_FAD_BS.
InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
InterPro; IPR011281; Succ_DH_flav_su_fwd.
InterPro; IPR014006; Succ_Dhase_FrdA_Gneg.
Pfam; PF00890; FAD_binding_2; 1.
Pfam; PF02910; Succ_DH_flav_C; 1.
SUPFAM; SSF46977; SSF46977; 1.
SUPFAM; SSF51905; SSF51905; 2.
SUPFAM; SSF56425; SSF56425; 1.
TIGRFAMs; TIGR01816; sdhA_forward; 1.
TIGRFAMs; TIGR01812; sdhA_frdA_Gneg; 1.
PROSITE; PS00504; FRD_SDH_FAD_BINDING; 1.
1: Evidence at protein level;
Complete proteome; Electron transport; FAD; Flavoprotein; Membrane;
Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
Reference proteome; Transit peptide; Transport;
Tricarboxylic acid cycle.
TRANSIT 1 29 Mitochondrion. {ECO:0000255}.
CHAIN 30 632 Succinate dehydrogenase [ubiquinone]
flavoprotein subunit 2, mitochondrial.
/FTId=PRO_0000247592.
NP_BIND 54 59 FAD. {ECO:0000250|UniProtKB:Q9YHT1}.
NP_BIND 77 92 FAD. {ECO:0000250|UniProtKB:Q9YHT1}.
NP_BIND 444 445 FAD. {ECO:0000250|UniProtKB:Q9YHT1}.
ACT_SITE 327 327 Proton acceptor.
{ECO:0000250|UniProtKB:Q9YHT1}.
BINDING 262 262 FAD. {ECO:0000250|UniProtKB:Q9YHT1}.
BINDING 283 283 Substrate.
{ECO:0000250|UniProtKB:Q9YHT1}.
BINDING 295 295 Substrate.
{ECO:0000250|UniProtKB:Q9YHT1}.
BINDING 394 394 Substrate.
{ECO:0000250|UniProtKB:Q9YHT1}.
BINDING 428 428 FAD. {ECO:0000250|UniProtKB:Q9YHT1}.
BINDING 439 439 Substrate.
{ECO:0000250|UniProtKB:Q9YHT1}.
MOD_RES 85 85 Tele-8alpha-FAD histidine.
{ECO:0000250|UniProtKB:Q9YHT1}.
SEQUENCE 632 AA; 69363 MW; DEC34651679CEF88 CRC64;
MWRCLRVASS SRRSESNGAF ITSQLSRFFS APPSAGDKSS YTIVDHTYDA VVVGAGGAGL
RAAIGLSEHG FNTACITKLF PTRSHTVAAQ GGINAALGNM SVDDWRWHMY DTVKGSDWLG
DQDAIQYMCR EAPKAVIELE NYGLPFSRTE DGKIYQRAFG GQSLEFGIGG QAYRCACAAD
RTGHALLHTL YGQAMKHNTQ FFVEYFALDL IMNSDGTCQG VIALNMEDGT LHRFHAGSTI
LATGGYGRAY FSATSAHTCT GDGNAMVARA GLPLQDLEFV QFHPTGIYGA GCLITEGARG
EGGILRNSEG EKFMDRYAPT ARDLASRDVV SRSMTMEIRQ GRGAGPMKDY LYLYLNHLPP
EVLKERLPGI SETAAIFAGV DVTREPIPVL PTVHYNMGGI PTNYHGEVIT LRGDDPDAVV
PGLMAAGEAA CASVHGANRL GANSLLDIVV FGRACANRVA EIQKPGEKLK PLEKDAGEKS
IEWLDRIRNS NGSLPTSKIR LNMQRVMQNN AAVFRTQETL EEGCDLIDKT WDSFGDVKVT
DRSMIWNSDL IETMELENLL VNACITMHSA EARKESRGAH AREDFTKRDD ANWMKHTLGY
WEEGNVKLEY RPVHMKTLDD EVDTFPPKPR VY


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