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Succinate-acetate/proton symporter SatP (Succinate-acetate transporter protein)

 SATP_ECOLI              Reviewed;         188 AA.
P0AC98; P28695; Q8KMY2;
08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
08-NOV-2005, sequence version 1.
12-SEP-2018, entry version 94.
RecName: Full=Succinate-acetate/proton symporter SatP;
AltName: Full=Succinate-acetate transporter protein;
Name=satP; Synonyms=yaaH; OrderedLocusNames=b0010, JW0009;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8400364; DOI=10.3109/10425179309020832;
James R., Dean D.O., Debbage J.;
"Five open reading frames upstream of the dnaK gene of E. coli.";
DNA Seq. 3:327-332(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12;
PubMed=1630901; DOI=10.1093/nar/20.13.3305;
Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N.,
Isono K., Mizobuchi K., Nakata A.;
"Systematic sequencing of the Escherichia coli genome: analysis of the
0-2.4 min region.";
Nucleic Acids Res. 20:3305-3308(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION
TO 111.
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[5]
TOPOLOGY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=15919996; DOI=10.1126/science.1109730;
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
"Global topology analysis of the Escherichia coli inner membrane
proteome.";
Science 308:1321-1323(2005).
[6]
FUNCTION, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES,
DISRUPTION PHENOTYPE, GENE NAME, AND MUTAGENESIS OF LEU-131 AND
ALA-164.
STRAIN=K12 / MG1693;
PubMed=23844911; DOI=10.1042/BJ20130412;
Sa-Pessoa J., Paiva S., Ribas D., Silva I.J., Viegas S.C.,
Arraiano C.M., Casal M.;
"SATP (YaaH), a succinate-acetate transporter protein in Escherichia
coli.";
Biochem. J. 454:585-595(2013).
-!- FUNCTION: Uptake of acetate and succinate. Transport is
energetically dependent on the protonmotive force.
{ECO:0000269|PubMed:23844911}.
-!- ACTIVITY REGULATION: Transport is inhibited by the protonophore
CCCP. {ECO:0000269|PubMed:23844911}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=1.24 mM for acetic acid {ECO:0000269|PubMed:23844911};
KM=1.18 mM for succinic acid {ECO:0000269|PubMed:23844911};
Vmax=8.72 nmol/min/mg enzyme with acetic acid as substrate
{ECO:0000269|PubMed:23844911};
Vmax=10.05 nmol/min/mg enzyme with succinic acid as substrate
{ECO:0000269|PubMed:23844911};
pH dependence:
Optimum pH is 6.0. {ECO:0000269|PubMed:23844911};
-!- SUBCELLULAR LOCATION: Cell inner membrane
{ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
{ECO:0000269|PubMed:15919996}.
-!- DISRUPTION PHENOTYPE: Mutant shows a partial reduction in acetate
uptake. {ECO:0000269|PubMed:23844911}.
-!- SIMILARITY: Belongs to the acetate uptake transporter (AceTr) (TC
2.A.96) family. {ECO:0000305}.
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EMBL; X67700; CAA47931.1; -; Genomic_DNA.
EMBL; U00096; AAC73121.1; -; Genomic_DNA.
EMBL; AP009048; BAB96588.2; -; Genomic_DNA.
PIR; E56688; E56688.
RefSeq; NP_414551.1; NC_000913.3.
RefSeq; WP_000528538.1; NZ_LN832404.1.
ProteinModelPortal; P0AC98; -.
SMR; P0AC98; -.
STRING; 316385.ECDH10B_0010; -.
TCDB; 2.A.96.1.1; the acetate uptake transporter (acetr) family.
PaxDb; P0AC98; -.
PRIDE; P0AC98; -.
EnsemblBacteria; AAC73121; AAC73121; b0010.
EnsemblBacteria; BAB96588; BAB96588; BAB96588.
GeneID; 944792; -.
KEGG; ecj:JW0009; -.
KEGG; eco:b0010; -.
PATRIC; fig|511145.12.peg.9; -.
EchoBASE; EB1474; -.
EcoGene; EG11512; satP.
eggNOG; ENOG4106HK8; Bacteria.
eggNOG; COG1584; LUCA.
HOGENOM; HOG000224166; -.
InParanoid; P0AC98; -.
KO; K07034; -.
OMA; WKKGNTF; -.
PhylomeDB; P0AC98; -.
BioCyc; EcoCyc:EG11512-MONOMER; -.
BioCyc; MetaCyc:EG11512-MONOMER; -.
PRO; PR:P0AC98; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
GO; GO:0015360; F:acetate:proton symporter activity; IDA:EcoCyc.
GO; GO:0035433; P:acetate transmembrane transport; IMP:EcoCyc.
GO; GO:0071422; P:succinate transmembrane transport; IDA:EcoCyc.
InterPro; IPR000791; Grp1/Fun34/SatP.
Pfam; PF01184; Grp1_Fun34_YaaH; 1.
PROSITE; PS01114; GPR1_FUN34_YAAH; 1.
1: Evidence at protein level;
Cell inner membrane; Cell membrane; Complete proteome; Ion transport;
Membrane; Reference proteome; Symport; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 188 Succinate-acetate/proton symporter SatP.
/FTId=PRO_0000135703.
TOPO_DOM 1 13 Cytoplasmic. {ECO:0000255}.
TRANSMEM 14 34 Helical. {ECO:0000255}.
TOPO_DOM 35 35 Periplasmic. {ECO:0000255}.
TRANSMEM 36 56 Helical. {ECO:0000255}.
TOPO_DOM 57 63 Cytoplasmic. {ECO:0000255}.
TRANSMEM 64 84 Helical. {ECO:0000255}.
TOPO_DOM 85 97 Periplasmic. {ECO:0000255}.
TRANSMEM 98 118 Helical. {ECO:0000255}.
TOPO_DOM 119 122 Cytoplasmic. {ECO:0000255}.
TRANSMEM 123 143 Helical. {ECO:0000255}.
TOPO_DOM 144 148 Periplasmic. {ECO:0000255}.
TRANSMEM 149 169 Helical. {ECO:0000255}.
TOPO_DOM 170 188 Cytoplasmic. {ECO:0000255}.
MUTAGEN 131 131 L->V: Acquires ability to transport
lactic acid.
{ECO:0000269|PubMed:23844911}.
MUTAGEN 164 164 A->G: Acquires ability to transport
lactic acid.
{ECO:0000269|PubMed:23844911}.
SEQUENCE 188 AA; 20071 MW; 972101DD5949EBF4 CRC64;
MGNTKLANPA PLGLMGFGMT TILLNLHNVG YFALDGIILA MGIFYGGIAQ IFAGLLEYKK
GNTFGLTAFT SYGSFWLTLV AILLMPKLGL TDAPNAQFLG VYLGLWGVFT LFMFFGTLKG
ARVLQFVFFS LTVLFALLAI GNIAGNAAII HFAGWIGLIC GASAIYLAMG EVLNEQFGRT
VLPIGESH


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