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Sulfur carrier protein CysO (9.5 kDa culture filtrate antigen cfp10A)

 CYSO_MYCTU              Reviewed;          93 AA.
P9WP33; L0T9C0; P0A646; Q10646;
16-APR-2014, integrated into UniProtKB/Swiss-Prot.
16-APR-2014, sequence version 1.
22-NOV-2017, entry version 26.
RecName: Full=Sulfur carrier protein CysO;
AltName: Full=9.5 kDa culture filtrate antigen cfp10A;
Name=cysO; Synonyms=cfp10A; OrderedLocusNames=Rv1335;
ORFNames=MTCY130.20;
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
NCBI_TaxID=83332;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
Oettinger T.;
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
PubMed=9634230; DOI=10.1038/31159;
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence.";
Nature 393:537-544(1998).
[3]
IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=ATCC 25618 / H37Rv;
PubMed=11681203;
DOI=10.1002/1615-9861(200104)1:4<494::AID-PROT494>3.0.CO;2-4;
Mattow J., Jungblut P.R., Mueller E.-C., Kaufmann S.H.E.;
"Identification of acidic, low molecular mass proteins of
Mycobacterium tuberculosis strain H37Rv by matrix-assisted laser
desorption/ionization and electrospray ionization mass spectrometry.";
Proteomics 1:494-507(2001).
[4]
INDUCTION.
STRAIN=ATCC 25618 / H37Rv;
PubMed=12123450; DOI=10.1046/j.1365-2958.2002.03005.x;
Manganelli R., Voskuil M.I., Schoolnik G.K., Dubnau E., Gomez M.,
Smith I.;
"Role of the extracytoplasmic-function sigma factor sigma(H) in
Mycobacterium tuberculosis global gene expression.";
Mol. Microbiol. 45:365-374(2002).
[5]
FUNCTION, AND THIOCARBOXYLATION AT GLY-93 BY MOEZ.
STRAIN=ATCC 25618 / H37Rv;
PubMed=16104727; DOI=10.1021/ja053476x;
Burns K.E., Baumgart S., Dorrestein P.C., Zhai H., McLafferty F.W.,
Begley T.P.;
"Reconstitution of a new cysteine biosynthetic pathway in
Mycobacterium tuberculosis.";
J. Am. Chem. Soc. 127:11602-11603(2005).
[6]
FUNCTION, AND KINETIC STUDIES.
PubMed=18842002; DOI=10.1021/bi8013664;
O'Leary S.E., Jurgenson C.T., Ealick S.E., Begley T.P.;
"O-phospho-L-serine and the thiocarboxylated sulfur carrier protein
CysO-COSH are substrates for CysM, a cysteine synthase from
Mycobacterium tuberculosis.";
Biochemistry 47:11606-11615(2008).
[7]
FUNCTION, MASS SPECTROMETRY, AND PTM.
STRAIN=ATCC 25618 / H37Rv;
PubMed=18799456; DOI=10.1074/jbc.M804877200;
Agren D., Schnell R., Oehlmann W., Singh M., Schneider G.;
"Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-
phosphoserine sulfhydrylase: evidence for an alternative cysteine
biosynthesis pathway in mycobacteria.";
J. Biol. Chem. 283:31567-31574(2008).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=ATCC 25618 / H37Rv;
PubMed=21969609; DOI=10.1074/mcp.M111.011627;
Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B.,
Yadav A.K., Shrivastava P., Marimuthu A., Anand S., Sundaram H.,
Kingsbury R., Harsha H.C., Nair B., Prasad T.S., Chauhan D.S.,
Katoch K., Katoch V.M., Kumar P., Chaerkady R., Ramachandran S.,
Dash D., Pandey A.;
"Proteogenomic analysis of Mycobacterium tuberculosis by high
resolution mass spectrometry.";
Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
[9]
X-RAY CRYSTALLOGRAPHY (1.53 ANGSTROMS) OF NATIVE PROTEIN AND COMPLEX
WITH PROTEIN CYSM.
PubMed=18771296; DOI=10.1021/bi800915j;
Jurgenson C.T., Burns K.E., Begley T.P., Ealick S.E.;
"Crystal structure of a sulfur carrier protein complex found in the
cysteine biosynthetic pathway of Mycobacterium tuberculosis.";
Biochemistry 47:10354-10364(2008).
-!- FUNCTION: In its thiocarboxylated form (CysO-COSH), is the sulfur
donor in the CysM-dependent cysteine biosynthetic pathway. May be
of particular importance for cysteine biosynthesis in the
persistent phase of M.tuberculosis. {ECO:0000269|PubMed:16104727,
ECO:0000269|PubMed:18799456, ECO:0000269|PubMed:18842002}.
-!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis.
-!- INDUCTION: Up-regulated under oxidative stress conditions.
{ECO:0000269|PubMed:12123450}.
-!- PTM: Thiocarboxylated by MoeZ. {ECO:0000269|PubMed:16104727}.
-!- PTM: A covalent CysO-cysteine adduct is formed by the action of
CysM. The structure of the adduct seems to be first a S-(glycyl)-
cysteinate which leads to a N-(glycyl)-cysteinate after a S->N
acyl shift. {ECO:0000269|PubMed:18799456}.
-!- MASS SPECTROMETRY: Mass=9557.5; Method=Unknown; Range=1-93;
Note=Native form.; Evidence={ECO:0000269|PubMed:18799456};
-!- MASS SPECTROMETRY: Mass=9573.8; Method=Unknown; Range=1-93;
Note=Thiocarboxylated form.;
Evidence={ECO:0000269|PubMed:18799456};
-!- MASS SPECTROMETRY: Mass=9659.6; Method=Unknown; Range=1-93;
Note=CysO-cysteine adduct.;
Evidence={ECO:0000269|PubMed:18799456};
-!- SIMILARITY: Belongs to the sulfur carrier protein CysO family.
{ECO:0000305}.
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EMBL; AJ007738; CAA07637.1; -; Genomic_DNA.
EMBL; AL123456; CCP44093.1; -; Genomic_DNA.
PIR; C70771; C70771.
RefSeq; NP_215851.1; NC_000962.3.
RefSeq; WP_003406910.1; NZ_KK339370.1.
PDB; 3DWG; X-ray; 1.53 A; C=1-93.
PDB; 3DWM; X-ray; 2.69 A; A/B=1-93.
PDBsum; 3DWG; -.
PDBsum; 3DWM; -.
ProteinModelPortal; P9WP33; -.
SMR; P9WP33; -.
STRING; 83332.Rv1335; -.
PaxDb; P9WP33; -.
EnsemblBacteria; CCP44093; CCP44093; Rv1335.
GeneID; 886879; -.
KEGG; mtu:Rv1335; -.
TubercuList; Rv1335; -.
eggNOG; ENOG4105K8D; Bacteria.
eggNOG; COG1977; LUCA.
KO; K03636; -.
OMA; CPGIKAR; -.
PhylomeDB; P9WP33; -.
BioCyc; MetaCyc:G185E-5514-MONOMER; -.
Reactome; R-MTU-936654; Cysteine synthesis from O-phosphoserine.
UniPathway; UPA00136; -.
Proteomes; UP000001584; Chromosome.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0043234; C:protein complex; IDA:MTBBASE.
GO; GO:0019344; P:cysteine biosynthetic process; IDA:MTBBASE.
GO; GO:0006535; P:cysteine biosynthetic process from serine; TAS:Reactome.
Gene3D; 3.10.20.30; -; 1.
InterPro; IPR012675; Beta-grasp_dom_sf.
InterPro; IPR016155; Mopterin_synth/thiamin_S_b.
InterPro; IPR003749; ThiS/MoaD.
Pfam; PF02597; ThiS; 1.
SUPFAM; SSF54285; SSF54285; 1.
1: Evidence at protein level;
3D-structure; Amino-acid biosynthesis; Complete proteome;
Cysteine biosynthesis; Reference proteome.
CHAIN 1 93 Sulfur carrier protein CysO.
/FTId=PRO_0000159082.
MOD_RES 93 93 1-thioglycine; alternate.
{ECO:0000269|PubMed:16104727}.
MOD_RES 93 93 CysO-cysteine adduct; alternate.
{ECO:0000269|PubMed:18799456}.
STRAND 3 6 {ECO:0000244|PDB:3DWG}.
HELIX 9 14 {ECO:0000244|PDB:3DWG}.
TURN 15 17 {ECO:0000244|PDB:3DWG}.
STRAND 19 23 {ECO:0000244|PDB:3DWG}.
HELIX 28 38 {ECO:0000244|PDB:3DWG}.
HELIX 42 46 {ECO:0000244|PDB:3DWG}.
STRAND 49 51 {ECO:0000244|PDB:3DWG}.
STRAND 59 63 {ECO:0000244|PDB:3DWG}.
HELIX 68 70 {ECO:0000244|PDB:3DWG}.
HELIX 73 75 {ECO:0000244|PDB:3DWG}.
STRAND 83 88 {ECO:0000244|PDB:3DWG}.
SEQUENCE 93 AA; 9557 MW; CA53151BC14742A8 CRC64;
MNVTVSIPTI LRPHTGGQKS VSASGDTLGA VISDLEANYS GISERLMDPS SPGKLHRFVN
IYVNDEDVRF SGGLATAIAD GDSVTILPAV AGG


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