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Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)

 SODM_BOVIN              Reviewed;         222 AA.
P41976; Q2KJE8; Q5E9D2; Q862F8;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
30-AUG-2017, entry version 119.
RecName: Full=Superoxide dismutase [Mn], mitochondrial;
EC=1.15.1.1;
Flags: Precursor;
Name=SOD2;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Lung;
PubMed=8292376; DOI=10.1165/ajrcmb.10.1.8292376;
Meyrick B., Magnuson M.A.;
"Identification and functional characterization of the bovine
manganous superoxide dismutase promoter.";
Am. J. Respir. Cell Mol. Biol. 10:113-121(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=16305752; DOI=10.1186/1471-2164-6-166;
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
"Characterization of 954 bovine full-CDS cDNA sequences.";
BMC Genomics 6:166-166(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 93-201.
PubMed=12658628; DOI=10.1002/mrd.10292;
Ishiwata H., Katsuma S., Kizaki K., Patel O.V., Nakano H.,
Takahashi T., Imai K., Hirasawa A., Shiojima S., Ikawa H., Suzuki Y.,
Tsujimoto G., Izaike Y., Todoroki J., Hashizume K.;
"Characterization of gene expression profiles in early bovine
pregnancy using a custom cDNA microarray.";
Mol. Reprod. Dev. 65:9-18(2003).
-!- FUNCTION: Destroys superoxide anion radicals which are normally
produced within the cells and which are toxic to biological
systems.
-!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
-!- SUBUNIT: Homotetramer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Mitochondrion matrix.
-!- PTM: Nitrated under oxidative stress. Nitration coupled with
oxidation inhibits the catalytic activity (By similarity).
{ECO:0000250}.
-!- PTM: Acetylation at Lys-122 decreases enzymatic activity.
Deacetylated by SIRT3 upon exposure to ionizing radiations or
after long fasting (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA30655.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; L22092; AAA30655.1; ALT_INIT; mRNA.
EMBL; L22093; AAA30656.1; -; Genomic_DNA.
EMBL; S67818; AAC60522.2; -; mRNA.
EMBL; S67819; AAD14001.1; -; Genomic_DNA.
EMBL; BT020988; AAX09005.1; -; mRNA.
EMBL; BC105378; AAI05379.1; -; mRNA.
EMBL; AB099036; BAC56526.1; -; mRNA.
PIR; I51918; I51918.
RefSeq; NP_963285.2; NM_201527.2.
RefSeq; XP_010807032.1; XM_010808730.1.
UniGene; Bt.4748; -.
ProteinModelPortal; P41976; -.
SMR; P41976; -.
BioGrid; 158821; 2.
STRING; 9913.ENSBTAP00000008569; -.
PaxDb; P41976; -.
PeptideAtlas; P41976; -.
PRIDE; P41976; -.
GeneID; 104973000; -.
GeneID; 281496; -.
KEGG; bta:104973000; -.
KEGG; bta:281496; -.
CTD; 6648; -.
eggNOG; KOG0876; Eukaryota.
eggNOG; COG0605; LUCA.
HOVERGEN; HBG004451; -.
InParanoid; P41976; -.
KO; K04564; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO; GO:0030145; F:manganese ion binding; ISS:UniProtKB.
GO; GO:0004784; F:superoxide dismutase activity; ISS:UniProtKB.
GO; GO:0001315; P:age-dependent response to reactive oxygen species; ISS:UniProtKB.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0006801; P:superoxide metabolic process; ISS:UniProtKB.
InterPro; IPR001189; Mn/Fe_SOD.
InterPro; IPR019833; Mn/Fe_SOD_BS.
InterPro; IPR019832; Mn/Fe_SOD_C.
InterPro; IPR019831; Mn/Fe_SOD_N.
Pfam; PF02777; Sod_Fe_C; 1.
Pfam; PF00081; Sod_Fe_N; 1.
PIRSF; PIRSF000349; SODismutase; 1.
PRINTS; PR01703; MNSODISMTASE.
SUPFAM; SSF46609; SSF46609; 1.
SUPFAM; SSF54719; SSF54719; 1.
PROSITE; PS00088; SOD_MN; 1.
2: Evidence at transcript level;
Acetylation; Complete proteome; Manganese; Metal-binding;
Mitochondrion; Nitration; Oxidoreductase; Reference proteome;
Transit peptide.
TRANSIT 1 24 Mitochondrion. {ECO:0000250}.
CHAIN 25 222 Superoxide dismutase [Mn], mitochondrial.
/FTId=PRO_0000032866.
METAL 50 50 Manganese. {ECO:0000250}.
METAL 98 98 Manganese. {ECO:0000250}.
METAL 183 183 Manganese. {ECO:0000250}.
METAL 187 187 Manganese. {ECO:0000250}.
MOD_RES 58 58 Nitrated tyrosine.
{ECO:0000250|UniProtKB:P04179}.
MOD_RES 68 68 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:P04179}.
MOD_RES 68 68 N6-succinyllysine; alternate.
{ECO:0000250|UniProtKB:P09671}.
MOD_RES 75 75 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:P09671}.
MOD_RES 75 75 N6-succinyllysine; alternate.
{ECO:0000250|UniProtKB:P09671}.
MOD_RES 122 122 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:P09671}.
MOD_RES 122 122 N6-succinyllysine; alternate.
{ECO:0000250|UniProtKB:P09671}.
MOD_RES 130 130 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:P04179}.
MOD_RES 130 130 N6-succinyllysine; alternate.
{ECO:0000250|UniProtKB:P09671}.
MOD_RES 202 202 N6-acetyllysine.
{ECO:0000250|UniProtKB:P09671}.
CONFLICT 8 8 S -> R (in Ref. 1; AAD14001).
{ECO:0000305}.
CONFLICT 14 14 V -> A (in Ref. 2; AAX09005).
{ECO:0000305}.
CONFLICT 90 90 F -> V (in Ref. 1; AAC60522).
{ECO:0000305}.
CONFLICT 94 95 GH -> AI (in Ref. 4; BAC56526).
{ECO:0000305}.
SEQUENCE 222 AA; 24638 MW; 806CC3FCB1A74413 CRC64;
MLSRAACSTS RRLVPALSVL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN
NLNVAEEKYR EALEKGDVTA QIALQPALKF NGGGHINHSI FWTNLSPNGG GEPQGELLEA
IKRDFGSFAK FKEKLTAVSV GVQGSGWGWL GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL
GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTARYTAC SK


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