Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)

 VMAT2_RAT               Reviewed;         515 AA.
Q01827; Q9QVP1;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
19-SEP-2003, sequence version 2.
20-JUN-2018, entry version 136.
RecName: Full=Synaptic vesicular amine transporter;
AltName: Full=Monoamine transporter;
AltName: Full=Solute carrier family 18 member 2;
AltName: Full=Vesicular amine transporter 2;
Short=VAT2;
Name=Slc18a2; Synonyms=Svat, Vmat2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1505023; DOI=10.1016/0092-8674(92)90425-C;
Liu Y., Peter D., Roghani A., Schuldiner S., Prive G.G., Eisenberg D.,
Brecha N., Edwards R.H.;
"A cDNA that suppresses MPP+ toxicity encodes a vesicular amine
transporter.";
Cell 70:539-551(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1438304; DOI=10.1073/pnas.89.22.10993;
Erickson J.D., Eiden L.E., Hoffman B.J.;
"Expression cloning of a reserpine-sensitive vesicular monoamine
transporter.";
Proc. Natl. Acad. Sci. U.S.A. 89:10993-10997(1992).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Gastric corpus;
PubMed=8745292; DOI=10.1113/jphysiol.1996.sp021140;
Dimaline R., Struthers J.;
"Expression and regulation of a vesicular monoamine transporter in rat
stomach: a putative histamine transporter.";
J. Physiol. (Lond.) 490:249-256(1996).
[4]
PHOSPHORYLATION AT SER-512 AND SER-514.
PubMed=9045708; DOI=10.1074/jbc.272.10.6752;
Krantz D.E., Peter D., Lui Y., Edwards R.H.;
"Phosphorylation of a vesicular monoamine transporter by casein kinase
II.";
J. Biol. Chem. 272:6752-6759(1997).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-512 AND SER-514, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Involved in the ATP-dependent vesicular transport of
biogenic amine neurotransmitters. Pumps cytosolic monoamines
including dopamine, norepinephrine, serotonin, and histamine into
synaptic vesicles. Requisite for vesicular amine storage prior to
secretion via exocytosis.
-!- SUBUNIT: Interacts with SLC6A3. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Multi-pass
membrane protein.
-!- TISSUE SPECIFICITY: Brainstem and stomach.
-!- SIMILARITY: Belongs to the major facilitator superfamily.
Vesicular transporter family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; M97381; AAA42190.1; -; mRNA.
EMBL; L00603; AAA41627.1; -; mRNA.
PIR; A46374; A46374.
RefSeq; NP_037163.1; NM_013031.1.
RefSeq; XP_006231726.1; XM_006231664.3.
RefSeq; XP_017444313.1; XM_017588824.1.
UniGene; Rn.9686; -.
ProteinModelPortal; Q01827; -.
STRING; 10116.ENSRNOP00000011983; -.
BindingDB; Q01827; -.
ChEMBL; CHEMBL4828; -.
GuidetoPHARMACOLOGY; 1012; -.
iPTMnet; Q01827; -.
PhosphoSitePlus; Q01827; -.
PaxDb; Q01827; -.
PRIDE; Q01827; -.
GeneID; 25549; -.
KEGG; rno:25549; -.
CTD; 6571; -.
RGD; 3694; Slc18a2.
eggNOG; KOG3764; Eukaryota.
eggNOG; ENOG410XW69; LUCA.
HOGENOM; HOG000018545; -.
HOVERGEN; HBG055082; -.
InParanoid; Q01827; -.
KO; K08155; -.
PhylomeDB; Q01827; -.
TreeFam; TF313494; -.
PRO; PR:Q01827; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0043679; C:axon terminus; IDA:RGD.
GO; GO:0044297; C:cell body; IDA:RGD.
GO; GO:0042995; C:cell projection; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0031045; C:dense core granule; IDA:RGD.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0043005; C:neuron projection; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0008021; C:synaptic vesicle; IDA:RGD.
GO; GO:0030672; C:synaptic vesicle membrane; IDA:RGD.
GO; GO:0043195; C:terminal bouton; IDA:RGD.
GO; GO:0005275; F:amine transmembrane transporter activity; IDA:RGD.
GO; GO:0008144; F:drug binding; IPI:RGD.
GO; GO:0015238; F:drug transmembrane transporter activity; IEA:InterPro.
GO; GO:0019899; F:enzyme binding; IPI:RGD.
GO; GO:0031072; F:heat shock protein binding; IPI:RGD.
GO; GO:0015222; F:serotonin transmembrane transporter activity; IDA:RGD.
GO; GO:0007568; P:aging; IDA:RGD.
GO; GO:0015842; P:aminergic neurotransmitter loading into synaptic vesicle; IMP:RGD.
GO; GO:0071242; P:cellular response to ammonium ion; IEP:RGD.
GO; GO:0035690; P:cellular response to drug; IDA:RGD.
GO; GO:0032456; P:endocytic recycling; IEP:RGD.
GO; GO:0042593; P:glucose homeostasis; IDA:RGD.
GO; GO:0030073; P:insulin secretion; IDA:RGD.
GO; GO:0015844; P:monoamine transport; IDA:RGD.
GO; GO:0051589; P:negative regulation of neurotransmitter transport; IMP:RGD.
GO; GO:0006836; P:neurotransmitter transport; IDA:RGD.
GO; GO:0001975; P:response to amphetamine; IEP:RGD.
GO; GO:0042220; P:response to cocaine; IEP:RGD.
GO; GO:0051412; P:response to corticosterone; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0009635; P:response to herbicide; IEP:RGD.
GO; GO:0010038; P:response to metal ion; IEP:RGD.
GO; GO:0042594; P:response to starvation; IEP:RGD.
GO; GO:0010043; P:response to zinc ion; IEP:RGD.
CDD; cd06174; MFS; 1.
InterPro; IPR011701; MFS.
InterPro; IPR020846; MFS_dom.
InterPro; IPR036259; MFS_trans_sf.
InterPro; IPR004734; Multidrug-R.
Pfam; PF07690; MFS_1; 1.
SUPFAM; SSF103473; SSF103473; 2.
TIGRFAMs; TIGR00880; 2_A_01_02; 1.
PROSITE; PS50850; MFS; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasmic vesicle; Disulfide bond; Glycoprotein;
Membrane; Neurotransmitter transport; Phosphoprotein;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 515 Synaptic vesicular amine transporter.
/FTId=PRO_0000127516.
TOPO_DOM 1 20 Cytoplasmic. {ECO:0000255}.
TRANSMEM 21 41 Helical. {ECO:0000255}.
TOPO_DOM 42 130 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 131 151 Helical. {ECO:0000255}.
TOPO_DOM 152 160 Cytoplasmic. {ECO:0000255}.
TRANSMEM 161 181 Helical. {ECO:0000255}.
TOPO_DOM 182 190 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 191 211 Helical. {ECO:0000255}.
TOPO_DOM 212 220 Cytoplasmic. {ECO:0000255}.
TRANSMEM 221 243 Helical. {ECO:0000255}.
TOPO_DOM 244 249 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 250 272 Helical. {ECO:0000255}.
TOPO_DOM 273 292 Cytoplasmic. {ECO:0000255}.
TRANSMEM 293 312 Helical. {ECO:0000255}.
TOPO_DOM 313 329 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 330 353 Helical. {ECO:0000255}.
TOPO_DOM 354 358 Cytoplasmic. {ECO:0000255}.
TRANSMEM 359 379 Helical. {ECO:0000255}.
TOPO_DOM 380 390 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 391 411 Helical. {ECO:0000255}.
TOPO_DOM 412 415 Cytoplasmic. {ECO:0000255}.
TRANSMEM 416 436 Helical. {ECO:0000255}.
TOPO_DOM 437 441 Lumenal, vesicle. {ECO:0000255}.
TRANSMEM 442 463 Helical. {ECO:0000255}.
TOPO_DOM 464 515 Cytoplasmic. {ECO:0000255}.
MOD_RES 512 512 Phosphoserine; by CK2.
{ECO:0000244|PubMed:22673903,
ECO:0000269|PubMed:9045708}.
MOD_RES 514 514 Phosphoserine; by CK2.
{ECO:0000244|PubMed:22673903,
ECO:0000269|PubMed:9045708}.
CARBOHYD 56 56 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 80 80 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 81 81 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 89 89 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 111 111 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 118 325 {ECO:0000250}.
CONFLICT 220 221 KP -> NA (in Ref. 2; AAA41627).
{ECO:0000305}.
CONFLICT 397 397 G -> F (in Ref. 1; AAA42190).
{ECO:0000305}.
CONFLICT 493 493 R -> T (in Ref. 2; AAA41627).
{ECO:0000305}.
SEQUENCE 515 AA; 55690 MW; 627A904C1D35D552 CRC64;
MALSDLVLLR WLRDSRHSRK LILFIVFLAL LLDNMLLTVV VPIIPSYLYS IKHEKNSTEI
QTTRPELVVS TSESIFSYYN NSTVLITGNA TGTLPGGQSH KATSTQHTVA NTTVPSDCPS
EDRDLLNENV QVGLLFASKA TVQLLTNPFI GLLTNRIGYP IPMFAGFCIM FISTVMFAFS
SSYAFLLIAR SLQGIGSSCS SVAGMGMLAS VYTDDEERGK PMGIALGGLA MGVLVGPPFG
SVLYEFVGKT APFLVLAALV LLDGAIQLFV LQPSRVQPES QKGTPLTTLL KDPYILIAAG
SICFANMGIA MLEPALPIWM METMCSRKWQ LGVAFLPASI SYLIGTNIFG ILAHKMGRWL
CALLGMVIVG ISILCIPFAK NIYGLIAPNF GVGFAIGMVD SSMMPIMGYL VDLRHVSVYG
SVYAIADVAF CMGYAIGPSA GGAIAKAIGF PWLMTIIGII DIAFAPLCFF LRSPPAKEEK
MAILMDHNCP IKRKMYTQNN VQSYPIGDDE ESESD


Related products :

Catalog number Product name Quantity
EIAAB45844 Monoamine transporter,Mouse,Mus musculus,Slc18a2,Solute carrier family 18 member 2,Synaptic vesicular amine transporter,VAT2,Vesicular amine transporter 2,Vmat2
EIAAB45843 Bos taurus,Bovine,Monoamine transporter,SLC18A2,Solute carrier family 18 member 2,Synaptic vesicular amine transporter,VAT2,Vesicular amine transporter 2,VMAT2
EIAAB45846 Monoamine transporter,Rat,Rattus norvegicus,Slc18a2,Solute carrier family 18 member 2,Svat,Synaptic vesicular amine transporter,VAT2,Vesicular amine transporter 2,Vmat2
EIAAB45845 Homo sapiens,Human,Monoamine transporter,SLC18A2,Solute carrier family 18 member 2,SVMT,Synaptic vesicular amine transporter,VAT2,Vesicular amine transporter 2,VMAT2
18-662-20028 Synaptic vesicular amine transporter - Monoamine transporter; Vesicular amine transporter 2; VAT2; Solute carrier family 18 member 2 Polyclonal 0.1 ml
18-003-42681 Chromaffin granule amine transporter - Vesicular amine transporter 1; VAT1; Solute carrier family 18 member 1 Polyclonal 0.05 mg Aff Pur
EIAAB45840 Chromaffin granule amine transporter,Mouse,Mus musculus,Slc18a1,Solute carrier family 18 member 1,VAT1,Vesicular amine transporter 1,Vmat1
EIAAB45841 Cgat,Chromaffin granule amine transporter,Rat,Rattus norvegicus,Slc18a1,Solute carrier family 18 member 1,VAT1,Vesicular amine transporter 1,Vmat1
EIAAB45842 Chromaffin granule amine transporter,Homo sapiens,Human,SLC18A1,Solute carrier family 18 member 1,VAT1,VAT1,Vesicular amine transporter 1,VMAT1
EIAAB45777 GABA and glycine transporter,Rat,Rattus norvegicus,rGVAT,Slc32a1,Solute carrier family 32 member 1,Vesicular GABA transporter,Vesicular inhibitory amino acid transporter,Vgat,Viaat
EIAAB45778 GABA and glycine transporter,Mouse,Mus musculus,mVGAT,mVIAAT,Slc32a1,Solute carrier family 32 member 1,Vesicular GABA transporter,Vesicular inhibitory amino acid transporter,Vgat,Viaat
EIAAB45779 GABA and glycine transporter,Homo sapiens,Human,hVIAAT,SLC32A1,Solute carrier family 32 member 1,Vesicular GABA transporter,Vesicular inhibitory amino acid transporter,VGAT,VIAAT
29-914 The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is 0.05 mg
DDB2_BOVIN Rat ELISA Kit FOR Synaptic vesicular amine transporter 96T
E0326h Rat ELISA Kit FOR Synaptic vesicular amine transporter 96T
KAD2_BOVIN Rat ELISA Kit FOR Synaptic vesicular amine transporter 96T
E1762b Bovine ELISA Kit FOR Synaptic vesicular amine transporter 96T
H3913 Synaptic vesicular amine transporter (SLC18A2), Rat, ELISA Kit 96T
CSB-EL021427RA Rat Synaptic vesicular amine transporter(SLC18A2) ELISA kit 96T
E1763h Mouse ELISA Kit FOR Synaptic vesicular amine transporter 96T
VMAT2_HUMAN Human ELISA Kit FOR Synaptic vesicular amine transporter 96T
H3911 Synaptic vesicular amine transporter (SLC18A2), Human, ELISA Kit 96T
CSB-EL021427BO Bovine Synaptic vesicular amine transporter(SLC18A2) ELISA kit 96T
H3910 Synaptic vesicular amine transporter (SLC18A2), Bovine, ELISA Kit 96T
H3912 Synaptic vesicular amine transporter (SLC18A2), Mouse, ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur