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Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein)

 SNP25_BOVIN             Reviewed;         206 AA.
Q17QQ3;
16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
25-JUL-2006, sequence version 1.
22-NOV-2017, entry version 92.
RecName: Full=Synaptosomal-associated protein 25;
Short=SNAP-25;
AltName: Full=Synaptosomal-associated 25 kDa protein;
Name=SNAP25;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Basal ganglia;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
[2]
ASSOCIATION WITH THE BLOC-1 COMPLEX, AND INTERACTION WITH BLOC1S6.
PubMed=19546860; DOI=10.1038/mp.2009.58;
Ghiani C.A., Starcevic M., Rodriguez-Fernandez I.A., Nazarian R.,
Cheli V.T., Chan L.N., Malvar J.S., de Vellis J., Sabatti C.,
Dell'Angelica E.C.;
"The dysbindin-containing complex (BLOC-1) in brain: developmental
regulation, interaction with SNARE proteins and role in neurite
outgrowth.";
Mol. Psychiatry 15:204-215(2010).
-!- FUNCTION: t-SNARE involved in the molecular regulation of
neurotransmitter release. May play an important role in the
synaptic function of specific neuronal systems. Associates with
proteins involved in vesicle docking and membrane fusion.
Regulates plasma membrane recycling through its interaction with
CENPF. Modulates the gating characteristics of the delayed
rectifier voltage-dependent potassium channel KCNB1 in pancreatic
beta cells (By similarity). {ECO:0000250,
ECO:0000250|UniProtKB:P60881}.
-!- SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2
and STX1A; this complex binds CPLX1 (By similarity). Found in a
complex containing SYT1, SV2B and syntaxin-1 (By similarity).
Found in a ternary complex with STX1A and VAMP8 (By similarity).
Isoform 1 and isoform 2 interact with BLOC1S6 (PubMed:19546860).
Interacts with CENPF (By similarity). Interacts with EQTN (By
similarity). Interacts with HGS (By similarity). Interacts with
KCNB1 (via N-terminus); reduces the voltage-dependent potassium
channel KCNB1 activity in pancreatic beta cells (By similarity).
Interacts with OTOF (By similarity). Interacts with RIMS1 (By
similarity). Interacts with SNAPIN (By similarity). Interacts with
STXBP6 (By similarity). Interacts with TRIM9 (By similarity).
Interacts with ZDHHC13 (via ANK repeats) (By similarity).
Interacts with ZDHHC17 (via ANK repeats) (By similarity).
Associates with the BLOC-1 complex (PubMed:19546860). Interacts
with PLCL1 (via C2 domain) (By similarity).
{ECO:0000250|UniProtKB:P60879, ECO:0000250|UniProtKB:P60881,
ECO:0000269|PubMed:19546860}.
-!- INTERACTION:
P61763:STXBP1; NbExp=3; IntAct=EBI-7336080, EBI-7335973;
-!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
{ECO:0000250|UniProtKB:P60879}. Cell membrane
{ECO:0000250|UniProtKB:P60881}; Lipid-anchor
{ECO:0000250|UniProtKB:P60879}. Cell junction, synapse,
synaptosome {ECO:0000250|UniProtKB:P60879}. Note=Membrane
association requires palmitoylation. Expressed throughout
cytoplasm, concentrating at the perinuclear region. Colocalizes
with KCNB1 at the cell membrane. {ECO:0000250|UniProtKB:P60879,
ECO:0000250|UniProtKB:P60881}.
-!- PTM: Palmitoylated. Cys-85 appears to be the main site, and
palmitoylation is required for membrane association (By
similarity). {ECO:0000250|UniProtKB:P60879}.
-!- SIMILARITY: Belongs to the SNAP-25 family. {ECO:0000305}.
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EMBL; BC118237; AAI18238.1; -; mRNA.
RefSeq; NP_001069714.1; NM_001076246.1.
UniGene; Bt.42529; -.
ProteinModelPortal; Q17QQ3; -.
SMR; Q17QQ3; -.
CORUM; Q17QQ3; -.
IntAct; Q17QQ3; 3.
MINT; MINT-4545122; -.
STRING; 9913.ENSBTAP00000010961; -.
iPTMnet; Q17QQ3; -.
PaxDb; Q17QQ3; -.
PRIDE; Q17QQ3; -.
Ensembl; ENSBTAT00000010961; ENSBTAP00000010961; ENSBTAG00000008323.
GeneID; 540853; -.
KEGG; bta:540853; -.
CTD; 6616; -.
eggNOG; KOG3065; Eukaryota.
eggNOG; ENOG410Y3Y0; LUCA.
GeneTree; ENSGT00390000012186; -.
HOGENOM; HOG000231599; -.
HOVERGEN; HBG056971; -.
InParanoid; Q17QQ3; -.
KO; K18211; -.
OMA; GEMDENL; -.
OrthoDB; EOG091G0N7J; -.
TreeFam; TF315125; -.
Reactome; R-BTA-449836; Other interleukin signaling.
Reactome; R-BTA-6798695; Neutrophil degranulation.
Proteomes; UP000009136; Chromosome 13.
Bgee; ENSBTAG00000008323; -.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0031083; C:BLOC-1 complex; IEA:Ensembl.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:Ensembl.
GO; GO:0030426; C:growth cone; IDA:UniProtKB.
GO; GO:0016020; C:membrane; ISS:UniProtKB.
GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0098794; C:postsynapse; IEA:Ensembl.
GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl.
GO; GO:0031201; C:SNARE complex; ISS:UniProtKB.
GO; GO:0036477; C:somatodendritic compartment; IEA:Ensembl.
GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO; GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; IBA:GO_Central.
GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
GO; GO:0017075; F:syntaxin-1 binding; IBA:GO_Central.
GO; GO:0008306; P:associative learning; IEA:Ensembl.
GO; GO:0098967; P:exocytic insertion of neurotransmitter receptor to postsynaptic membrane; IEA:Ensembl.
GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO; GO:0099590; P:neurotransmitter receptor internalization; IEA:Ensembl.
GO; GO:0031915; P:positive regulation of synaptic plasticity; IEA:Ensembl.
GO; GO:0070201; P:regulation of establishment of protein localization; IEA:Ensembl.
GO; GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
GO; GO:1990926; P:short-term synaptic potentiation; IEA:Ensembl.
GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
GO; GO:0016082; P:synaptic vesicle priming; IBA:GO_Central.
InterPro; IPR000928; SNAP-25.
InterPro; IPR000727; T_SNARE_dom.
Pfam; PF00835; SNAP-25; 1.
SMART; SM00397; t_SNARE; 2.
PROSITE; PS50192; T_SNARE; 2.
1: Evidence at protein level;
Cell junction; Cell membrane; Coiled coil; Complete proteome;
Cytoplasm; Lipoprotein; Membrane; Palmitate; Phosphoprotein;
Reference proteome; Repeat; Synapse; Synaptosome.
CHAIN 1 206 Synaptosomal-associated protein 25.
/FTId=PRO_0000355578.
DOMAIN 19 81 t-SNARE coiled-coil homology 1.
{ECO:0000255|PROSITE-ProRule:PRU00202}.
DOMAIN 140 202 t-SNARE coiled-coil homology 2.
{ECO:0000255|PROSITE-ProRule:PRU00202}.
REGION 1 75 Interaction with CENPF. {ECO:0000250}.
REGION 111 120 Interaction with ZDHHC17.
{ECO:0000250|UniProtKB:P60880}.
COMPBIAS 85 92 Cys-rich.
SITE 180 181 Cleavage; by BONT/E. {ECO:0000250}.
MOD_RES 138 138 Phosphothreonine.
{ECO:0000250|UniProtKB:P60879}.
MOD_RES 154 154 Phosphoserine.
{ECO:0000250|UniProtKB:P60879}.
MOD_RES 187 187 Phosphoserine.
{ECO:0000250|UniProtKB:P60879}.
LIPID 85 85 S-palmitoyl cysteine.
{ECO:0000250|UniProtKB:P60879}.
LIPID 88 88 S-palmitoyl cysteine.
{ECO:0000250|UniProtKB:P60879}.
LIPID 90 90 S-palmitoyl cysteine.
{ECO:0000250|UniProtKB:P60879}.
LIPID 92 92 S-palmitoyl cysteine.
{ECO:0000250|UniProtKB:P60879}.
SEQUENCE 206 AA; 23315 MW; FBED2B082A4CB6A6 CRC64;
MAEDADMRNE LEEMQRRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLERI
EEGMDQINKD MKEAEKNLTD LGKFCGLCVC PCNKLKSSDA YKKAWGNNQD GVVASQPARV
VDEREQMAIS GGFIRRVTND ARENEMDENL EQVSGIIGNL RHMALDMGNE IDTQNRQIDR
IMEKADSNKT RIDEANQRAT KMLGSG


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