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T-box protein VegT-A (Brachyury and Tbx-related protein) (T-box protein Brat) (T-box protein Antipodean)

 VEGTA_XENLA             Reviewed;         455 AA.
P87377; A2BDB3; B1H1N4; B7ZS85; P79930; P87386;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
15-DEC-2009, sequence version 2.
25-OCT-2017, entry version 89.
RecName: Full=T-box protein VegT-A;
AltName: Full=Brachyury and Tbx-related protein;
Short=T-box protein Brat;
AltName: Full=T-box protein Antipodean;
Name=vegt-a; Synonyms=apod, brat, vegt;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR
LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
TISSUE=Oocyte;
PubMed=9012531;
Zhang J., King M.L.;
"Xenopus VegT RNA is localized to the vegetal cortex during oogenesis
and encodes a novel T-box transcription factor involved in mesodermal
patterning.";
Development 122:4119-4129(1996).
[2]
SEQUENCE REVISION TO 209 AND 396-455.
Zhang J., King M.L.;
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY,
AND DEVELOPMENTAL STAGE.
TISSUE=Gastrula;
PubMed=9012537;
Stennard F., Carnac G., Gurdon J.B.;
"The Xenopus T-box gene, Antipodean, encodes a vegetally localised
maternal mRNA and can trigger mesoderm formation.";
Development 122:4179-4188(1996).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY,
DEVELOPMENTAL STAGE, AND INDUCTION.
TISSUE=Gastrula;
PubMed=9165117;
Horb M.E., Thomsen G.H.;
"A vegetally localized T-box transcription factor in Xenopus eggs
specifies mesoderm and endoderm and is essential for embryonic
mesoderm formation.";
Development 124:1689-1698(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Gastrula, and Ovary;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
[6]
FUNCTION.
PubMed=9735361;
Tada M., Casey E.S., Fairclough L., Smith J.C.;
"Bix1, a direct target of Xenopus T-box genes, causes formation of
ventral mesoderm and endoderm.";
Development 125:3997-4006(1998).
[7]
INDUCTION.
PubMed=10068640;
Sun B.I., Bush S.M., Collins-Racie L.A., LaVallie E.R.,
DiBlasio-Smith E.A., Wolfman N.M., McCoy J.M., Sive H.L.;
"derriere: a TGF-beta family member required for posterior development
in Xenopus.";
Development 126:1467-1482(1999).
[8]
FUNCTION.
PubMed=10518506;
Clements D., Friday R.V., Woodland H.R.;
"Mode of action of VegT in mesoderm and endoderm formation.";
Development 126:4903-4911(1999).
[9]
INDUCTION.
PubMed=10683175;
Hyde C.E., Old R.W.;
"Regulation of the early expression of the Xenopus nodal-related 1
gene, Xnr1.";
Development 127:1221-1229(2000).
[10]
INDUCTION.
PubMed=12070085;
Eimon P.M., Harland R.M.;
"Effects of heterodimerization and proteolytic processing on Derriere
and Nodal activity: implications for mesoderm induction in Xenopus.";
Development 129:3089-3103(2002).
[11]
TISSUE SPECIFICITY.
PubMed=12142022; DOI=10.1006/dbio.2002.0719;
Bubunenko M., Kress T.L., Vempati U.D., Mowry K.L., King M.L.;
"A consensus RNA signal that directs germ layer determinants to the
vegetal cortex of Xenopus oocytes.";
Dev. Biol. 248:82-92(2002).
[12]
FUNCTION, AND INTERACTION WITH TCF7L1; POU5F1.1; POU5F1.2 AND
POU5F1.3.
PubMed=17541407; DOI=10.1038/sj.emboj.7601736;
Cao Y., Siegel D., Donow C., Knochel S., Yuan L., Knochel W.;
"POU-V factors antagonize maternal VegT activity and beta-Catenin
signaling in Xenopus embryos.";
EMBO J. 26:2942-2954(2007).
-!- FUNCTION: Transcription factor required for both mesoderm and
endoderm formation in the embryo; signaling determinants and
concentration levels may determine which germ layer is formed.
Acts together with beta-catenin to activate genes that are
responsible for mesoderm induction including wnt-8, eomes t/bra,
siamois, mix1 and sox17. Directly binds to promoter DNA. Patterns
the mesoderm along the dorsoventral and posterior axis. Activates
siamois gene transcription when alone or in combination with beta-
catenin, but inhibits siamois transcription in combination with
pou5f1.1/oct-25. {ECO:0000269|PubMed:10518506,
ECO:0000269|PubMed:17541407, ECO:0000269|PubMed:9012531,
ECO:0000269|PubMed:9012537, ECO:0000269|PubMed:9165117,
ECO:0000269|PubMed:9735361}.
-!- SUBUNIT: Forms a repression complex on the promoters of the
nodal/nr1 and siamois genes with the maternal factors tcf7l1/tcf3
and pouf5.1/oct-25. Interacts (via C-terminus) with tcf7l1/tcf3
(via N-terminus). Also interacts with the other POU-domain
transcription factors pou5f1.2/oct-91 and pou5f1.3/oct-60.
{ECO:0000269|PubMed:17541407}.
-!- INTERACTION:
Q7T103:pou5f1.1; NbExp=3; IntAct=EBI-7439000, EBI-7438970;
Q90ZB6:tcf7l1-b; NbExp=4; IntAct=EBI-7439000, EBI-7439087;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00201, ECO:0000269|PubMed:9012531}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P87377-1; Sequence=Displayed;
Name=2;
IsoId=P87377-2; Sequence=VSP_038540;
-!- TISSUE SPECIFICITY: Uniformly distributed in stage I oocytes but
becomes localized to the vegetal hemisphere by stage II and
remains so thereafter throughout oogenesis and the early embryonic
cleavage stages. Zygotic expression parallels blastopore formation
and shifts from dorsal expression in the marginal zone of late
blastula and early gastrula stages to a ventral/lateral expression
at the posterior end of later stage embryos. Expression is
excluded from the notochord. In tailbud and tadpole stages,
expressed exclusively in a subset of posterior Rohon-Beard
neurons. {ECO:0000269|PubMed:12142022, ECO:0000269|PubMed:9012531,
ECO:0000269|PubMed:9012537, ECO:0000269|PubMed:9165117}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Maternally expressed from early oogenesis. Zygotic expression
occurs from late blastula and reaches maximum levels during
gastrulation (stages 10.5-12). Levels decline at the time of
blastopore closure (stage 13). {ECO:0000269|PubMed:9012531,
ECO:0000269|PubMed:9012537, ECO:0000269|PubMed:9165117}.
-!- INDUCTION: By mesoderm inducing factors and TGF-beta family
members including nodal/nr-1 acting in an autoregulatory loop,
nodal2/nr-2 derriere, bFGF and activin B.
{ECO:0000269|PubMed:10068640, ECO:0000269|PubMed:10683175,
ECO:0000269|PubMed:12070085, ECO:0000269|PubMed:9165117}.
-!- MISCELLANEOUS: Was named Antipodean by PubMed:9012537 because of
its localization to the vegetal hemisphere of the egg.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U59483; AAB93301.1; -; mRNA.
EMBL; X99905; CAA68179.1; -; mRNA.
EMBL; U89707; AAB49478.1; -; mRNA.
EMBL; BC130162; AAI30163.1; -; mRNA.
EMBL; BC160675; AAI60675.1; -; mRNA.
EMBL; BC170433; AAI70433.1; -; mRNA.
EMBL; BC170435; AAI70435.1; -; mRNA.
RefSeq; NP_001081665.1; NM_001088196.1.
RefSeq; XP_018088382.1; XM_018232893.1. [P87377-2]
UniGene; Xl.1775; -.
SMR; P87377; -.
IntAct; P87377; 4.
MINT; MINT-4979289; -.
MaxQB; P87377; -.
GeneID; 397986; -.
KEGG; xla:397986; -.
CTD; 397986; -.
Xenbase; XB-GENE-6252142; vegt.
HOVERGEN; HBG003537; -.
KO; K10180; -.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005667; C:transcription factor complex; IPI:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO; GO:0001707; P:mesoderm formation; IMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00182; TBOX; 1.
Gene3D; 2.60.40.820; -; 1.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR036960; T-box_sf.
InterPro; IPR001699; TF_T-box.
InterPro; IPR018186; TF_T-box_CS.
PANTHER; PTHR11267; PTHR11267; 1.
Pfam; PF00907; T-box; 1.
PRINTS; PR00937; TBOX.
SMART; SM00425; TBOX; 1.
SUPFAM; SSF49417; SSF49417; 1.
PROSITE; PS01283; TBOX_1; 1.
PROSITE; PS01264; TBOX_2; 1.
PROSITE; PS50252; TBOX_3; 1.
1: Evidence at protein level;
Activator; Alternative splicing; Developmental protein; DNA-binding;
Nucleus; Transcription; Transcription regulation.
CHAIN 1 455 T-box protein VegT-A.
/FTId=PRO_0000184462.
DNA_BIND 57 230 T-box. {ECO:0000255|PROSITE-
ProRule:PRU00201}.
VAR_SEQ 1 25 MRNCCRECGLSAGHLEPEASSNCAS -> MHSLP (in
isoform 2). {ECO:0000303|PubMed:9012537}.
/FTId=VSP_038540.
CONFLICT 244 244 L -> H (in Ref. 4; AAB49478).
{ECO:0000305}.
CONFLICT 350 350 T -> P (in Ref. 5; AAI60675).
{ECO:0000305}.
SEQUENCE 455 AA; 51771 MW; CF7FAC946A1847C0 CRC64;
MRNCCRECGL SAGHLEPEAS SNCASDVKSS PDMDSVSSQD SLYLPNTVGA SLEDQDLWSQ
FHQEGTEMII TKSGRRMFPQ CKIRLFGLHP YAKYMLLVDF VPLDNFRYKW NKNQWEAAGK
AEPHPPCRTY VHPDSPAPGA HWMKDPICFQ KLKLTNNTLD QQGHIILHSM HRYKPRFHVV
QSDDMYNSPW GLVQVFSFPE TEFTSVTAYQ NEKITKLKIN HNPFAKGFRE QERSHKRDDV
LKILQQSPSK RQKRKKWEDS PEADISDFPK AICVKEESIM DPAGVYQNWV SDHEANQGLT
PHSPESEGAN QEQQVPTSSS NFYNKSHYRR SSQHLSSPFE LGEPSSRRLT PDIATVPDSD
PDSLAVFHVI PTQNSAPERT CSMNFSMEAP MKQPLRGAMY SPYGADQWLV PAQGQYRPVG
YTAYPTDLST QGAVAHPHSA MSDWSQYSLF PYSCW


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