Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

T-box transcription factor TBX5-A (zftbx5a) (T-box protein 5) (zTbx5)

 TBX5A_DANRE             Reviewed;         492 AA.
Q9IAK8; B8JKS5; Q9PTK3; Q9PUS7;
28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
05-OCT-2010, sequence version 2.
05-DEC-2018, entry version 123.
RecName: Full=T-box transcription factor TBX5-A;
Short=zftbx5a;
AltName: Full=T-box protein 5;
Short=zTbx5;
Name=tbx5a; Synonyms=heartstrings, hst, tbx5, tbx5.1;
ORFNames=si:ch211-245e21.2;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
PubMed=10495283; DOI=10.1016/S0925-4773(99)00126-4;
Tamura K., Yonei-Tamura S., Belmonte J.C.I.;
"Differential expression of Tbx4 and Tbx5 in Zebrafish fin buds.";
Mech. Dev. 87:181-184(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=10664151; DOI=10.1007/s004270050014;
Ruvinsky I., Oates A.C., Silver L.M., Ho R.K.;
"The evolution of paired appendages in vertebrates: T-box genes in the
zebrafish.";
Dev. Genes Evol. 210:82-91(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 31-402.
PubMed=10640716; DOI=10.1016/S0925-4773(99)00246-4;
Begemann G., Ingham P.W.;
"Developmental regulation of Tbx5 in zebrafish embryogenesis.";
Mech. Dev. 90:299-304(2000).
[5]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=12223419;
Garrity D.M., Childs S., Fishman M.C.;
"The heartstrings mutation in zebrafish causes heart/fin Tbx5
deficiency syndrome.";
Development 129:4635-4645(2002).
[6]
FUNCTION, TISSUE SPECIFICITY, AND GENE DUPLICATION.
PubMed=19925885; DOI=10.1016/j.gep.2009.11.003;
Albalat R., Baquero M., Minguillon C.;
"Identification and characterisation of the developmental expression
pattern of tbx5b, a novel tbx5 gene in zebrafish.";
Gene Expr. Patterns 10:24-30(2010).
-!- FUNCTION: Required for pectoral fin formation. Together with
tbx5b, involved in eye and heart development. Required for the
looping stage of heart development. May bind to the core DNA motif
of promoters. {ECO:0000250|UniProtKB:Q99593,
ECO:0000269|PubMed:12223419, ECO:0000269|PubMed:19925885}.
-!- SUBUNIT: Monomer. Homodimer (via the T-box); binds DNA as
homodimer. {ECO:0000250|UniProtKB:Q99593}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99593,
ECO:0000255|PROSITE-ProRule:PRU00201}. Cytoplasm
{ECO:0000250|UniProtKB:Q99593}. Note=Shuttles between the
cytoplasm and the nucleus. {ECO:0000250|UniProtKB:Q99593}.
-!- TISSUE SPECIFICITY: Expressed in the dorsal optic cup of
developing eye, pectoral fin buds and heart. At 31 hpf, when the
pectoral fin buds have begun bulging outwards, restricted
expression is detected throughout the mesenchyme of the early fin
buds and these high levels of expression continue until later
stages. {ECO:0000269|PubMed:10664151, ECO:0000269|PubMed:12223419,
ECO:0000269|PubMed:19925885}.
-!- DOMAIN: The T-Box domain binds to double-stranded DNA.
{ECO:0000250|UniProtKB:Q99593}.
-!- SEQUENCE CAUTION:
Sequence=AAF06733.1; Type=Frameshift; Positions=469; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF152607; AAF06733.1; ALT_FRAME; mRNA.
EMBL; AF179407; AAF59837.1; -; mRNA.
EMBL; CU181811; CAX14227.1; -; Genomic_DNA.
EMBL; AF185283; AAF22296.1; -; mRNA.
RefSeq; NP_001300611.1; NM_001313682.1.
RefSeq; XP_005168260.1; XM_005168203.3.
UniGene; Dr.81302; -.
SMR; Q9IAK8; -.
BioGrid; 78315; 1.
STRING; 7955.ENSDARP00000033053; -.
PaxDb; Q9IAK8; -.
PRIDE; Q9IAK8; -.
Ensembl; ENSDART00000037691; ENSDARP00000033053; ENSDARG00000024894.
GeneID; 30071; -.
KEGG; dre:30071; -.
CTD; 30071; -.
ZFIN; ZDB-GENE-991124-7; tbx5a.
eggNOG; KOG3585; Eukaryota.
eggNOG; ENOG410XSTS; LUCA.
GeneTree; ENSGT00940000156506; -.
HOGENOM; HOG000286001; -.
HOVERGEN; HBG007310; -.
InParanoid; Q9IAK8; -.
KO; K10179; -.
OrthoDB; EOG091G0I8R; -.
PhylomeDB; Q9IAK8; -.
TreeFam; TF106341; -.
Reactome; R-DRE-2032785; YAP1- and WWTR1 (TAZ)-stimulated gene expression.
PRO; PR:Q9IAK8; -.
Proteomes; UP000000437; Chromosome 5.
Bgee; ENSDARG00000024894; Expressed in 36 organ(s), highest expression level in pectoral appendage bud.
GO; GO:0015629; C:actin cytoskeleton; IPI:ZFIN.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IDA:ZFIN.
GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
GO; GO:0032993; C:protein-DNA complex; ISS:UniProtKB.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:ZFIN.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:UniProtKB.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0001103; F:RNA polymerase II repressing transcription factor binding; IPI:ZFIN.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
GO; GO:0009887; P:animal organ morphogenesis; IMP:ZFIN.
GO; GO:0003294; P:atrial ventricular junction remodeling; IMP:ZFIN.
GO; GO:0036302; P:atrioventricular canal development; IGI:ZFIN.
GO; GO:0003190; P:atrioventricular valve formation; IMP:ZFIN.
GO; GO:0055007; P:cardiac muscle cell differentiation; IGI:ZFIN.
GO; GO:0035050; P:embryonic heart tube development; IMP:ZFIN.
GO; GO:0003143; P:embryonic heart tube morphogenesis; IMP:ZFIN.
GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IMP:ZFIN.
GO; GO:0007507; P:heart development; IMP:ZFIN.
GO; GO:0003146; P:heart jogging; IMP:ZFIN.
GO; GO:0001947; P:heart looping; IMP:ZFIN.
GO; GO:0003007; P:heart morphogenesis; IMP:ZFIN.
GO; GO:0060174; P:limb bud formation; IMP:ZFIN.
GO; GO:0021554; P:optic nerve development; IGI:ZFIN.
GO; GO:0033339; P:pectoral fin development; IMP:ZFIN.
GO; GO:0035138; P:pectoral fin morphogenesis; IMP:ZFIN.
GO; GO:0003344; P:pericardium morphogenesis; IMP:ZFIN.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ZFIN.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:ZFIN.
GO; GO:0003342; P:proepicardium development; IMP:ZFIN.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:ZFIN.
GO; GO:0060042; P:retina morphogenesis in camera-type eye; IGI:ZFIN.
GO; GO:0006351; P:transcription, DNA-templated; IMP:ZFIN.
CDD; cd00182; TBOX; 1.
Gene3D; 2.60.40.820; -; 1.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR036960; T-box_sf.
InterPro; IPR001699; TF_T-box.
InterPro; IPR018186; TF_T-box_CS.
PANTHER; PTHR11267; PTHR11267; 1.
Pfam; PF00907; T-box; 1.
PRINTS; PR00937; TBOX.
SMART; SM00425; TBOX; 1.
SUPFAM; SSF49417; SSF49417; 1.
PROSITE; PS01283; TBOX_1; 1.
PROSITE; PS01264; TBOX_2; 1.
PROSITE; PS50252; TBOX_3; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Developmental protein; DNA-binding;
Nucleus; Reference proteome; Transcription; Transcription regulation.
CHAIN 1 492 T-box transcription factor TBX5-A.
/FTId=PRO_0000262468.
DNA_BIND 62 237 T-box. {ECO:0000250|UniProtKB:Q99593,
ECO:0000255|PROSITE-ProRule:PRU00201}.
COMPBIAS 343 346 Poly-Ser.
CONFLICT 282 282 S -> P (in Ref. 2; AAF59837).
{ECO:0000305}.
CONFLICT 284 284 S -> T (in Ref. 1; AAF06733, 2; AAF59837
and 4; AAF22296). {ECO:0000305}.
CONFLICT 296 296 G -> S (in Ref. 1; AAF06733 and 2;
AAF59837). {ECO:0000305}.
CONFLICT 402 402 V -> G (in Ref. 4; AAF22296).
{ECO:0000305}.
SEQUENCE 492 AA; 55183 MW; 83C4D08B46785EFC CRC64;
MADSEDTFRL QNSPSDSEPK DLQNEGKSDK QNAAVSKSPS SQTTYIQQGM EGIKVYLHER
ELWTKFHEVG TEMIITKAGR RMFPSFKVKV TGLNPKTKYI LLMDVVPADD HRYKFADNKW
SVTGKAEPAM PGRLYVHPDS PATGAHWMRQ LVSFQKLKLT NNHLDPFGHI ILNSMHKYQP
RIHIVKADEN NGFGSKNTAF CTHVFPETAF IAVTSYQNHK ITQLKIENNP FAKGFRGSDD
MELHRMSRMQ STKEYPVVPR STVRQRVGSS QSPFSGDVQG LSASGAISSQ YSCENGVSST
SQDLLPQSSS YHEHTQDYHC IKRKVEDECP AGEHPYKKPY VESSSSEDDH YYRPLSYSQS
LGLSGGAPYR PESSQRQACM YASAPQPPEP VPSLEDISWP GVPPYSVPQM ERLPYQHHFS
AHFASRQMPE AHGMYASSVS HQCSPSGGIQ SPSAGLQGNE YLYAHGLQRT LSPHQYHTVH
SVSIMHDWNE AS


Related products :

Catalog number Product name Quantity
EIAAB41638 Homo sapiens,Human,T-box protein 5,T-box transcription factor TBX5,TBX5
EIAAB41637 Rat,Rattus norvegicus,T-box protein 5,T-box transcription factor TBX5,Tbx5
EIAAB41636 Mouse,Mus musculus,T-box protein 5,T-box transcription factor TBX5,Tbx5
TBX5_MOUSE ELISA Kit FOR T-box transcription factor TBX5; organism: Mouse; gene name: Tbx5 96T
EIAAB41639 Chicken,Gallus gallus,T-box protein 5,T-box transcription factor TBX5,TBX5
CSB-EL023257CH Chicken T-box transcription factor TBX5(TBX5) ELISA kit SpeciesChicken 96T
ARP33403_P050 Anti-T-box transcription factor TBX5 (TBX5) Species_Reactivity: Human
TBX5_RAT ELISA Kit FOR T-box transcription factor TBX5; organism: Rat; gene name: Tbx5 96T
ARP33403_T200 Anti-T-box transcription factor TBX5 (TBX5) Species_Reactivity: Human
CSB-EL023257HU Human T-box transcription factor TBX5(TBX5) ELISA kit SpeciesHuman 96T
ARP33403_P100 Anti-T-box transcription factor TBX5 (TBX5) Species_Reactivity: Human
CSB-EL023257MO Mouse T-box transcription factor TBX5(TBX5) ELISA kit SpeciesMouse 96T
H4260 T-box transcription factor TBX5 (TBX5), Human, ELISA Kit 96T
CSB-EL023257RA Rat T-box transcription factor TBX5(TBX5) ELISA kit SpeciesRat 96T
CSB-EL023257MO Mouse T-box transcription factor TBX5(TBX5) ELISA kit 96T
H4261 T-box transcription factor TBX5 (TBX5), Mouse, ELISA Kit 96T
CSB-EL023257HU Human T-box transcription factor TBX5(TBX5) ELISA kit 96T
CSB-EL023257CH Chicken T-box transcription factor TBX5(TBX5) ELISA kit 96T
H4259 T-box transcription factor TBX5 (TBX5), Chicken, ELISA Kit 96T
H4262 T-box transcription factor TBX5 (TBX5), Rat, ELISA Kit 96T
CSB-EL023257RA Rat T-box transcription factor TBX5(TBX5) ELISA kit 96T
E1907b Mouse ELISA Kit FOR T-box transcription factor TBX5 96T
TBX5_HUMAN Human ELISA Kit FOR T-box transcription factor TBX5 96T
P3801Rb Rabbit Anti_T_box transcription factor TBX5 polycl 40ug/0.2ml
18-003-42098 Ets domain transcription factor - ESE3 transcription factor; EHF protein; DJ875K15.1.2 (Ets homologous factor (Ets-domain transcription factor. ESE-3B (Isoform 2))); ETS-family transcription factor EH 0.1 mg Protein A


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur