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T-cell antigen CD7 (GP40) (T-cell leukemia antigen) (T-cell surface antigen Leu-9) (TP41) (CD antigen CD7)

 CD7_HUMAN               Reviewed;         240 AA.
P09564;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
20-JUN-2018, entry version 172.
RecName: Full=T-cell antigen CD7;
AltName: Full=GP40;
AltName: Full=T-cell leukemia antigen;
AltName: Full=T-cell surface antigen Leu-9;
AltName: Full=TP41;
AltName: CD_antigen=CD7;
Flags: Precursor;
Name=CD7;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PALMITOYLATION AT CYS-198.
PubMed=3501369;
Aruffo A., Seed B.;
"Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS
cell expression system.";
EMBO J. 6:3313-3316(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1703303; DOI=10.1073/pnas.88.2.603;
Schanberg L.E., Fleenor D.E., Kurtzberg J., Haynes B.F., Kaufman R.E.;
"Isolation and characterization of the genomic human CD7 gene:
structural similarity with the murine Thy-1 gene.";
Proc. Natl. Acad. Sci. U.S.A. 88:603-607(1991).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Muscle;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 205-240.
PubMed=1711009; DOI=10.1007/BF00216694;
Yoshikawa K., Seto M., Ueda R., Obata Y., Notake K., Yokochi T.,
Takahashi T.;
"Molecular cloning of the gene coding for the human T cell
differentiation antigen CD7.";
Immunogenetics 33:352-360(1991).
[6]
TOPOLOGY.
PubMed=2479685;
Ware R.E., Scearce R.M., Dietz M.A., Starmer C.F., Palker T.J.,
Haynes B.F.;
"Characterization of the surface topography and putative tertiary
structure of the human CD7 molecule.";
J. Immunol. 143:3632-3640(1989).
[7]
INTERACTION WITH SECTM1.
PubMed=10652336; DOI=10.1074/jbc.275.5.3431;
Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.;
"Identification of CD7 as a cognate of the human K12 (SECTM1)
protein.";
J. Biol. Chem. 275:3431-3437(2000).
[8]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96.
TISSUE=Liver;
PubMed=19159218; DOI=10.1021/pr8008012;
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of
multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
[9]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96.
TISSUE=Leukemic T-cell;
PubMed=19349973; DOI=10.1038/nbt.1532;
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
Schiess R., Aebersold R., Watts J.D.;
"Mass-spectrometric identification and relative quantification of N-
linked cell surface glycoproteins.";
Nat. Biotechnol. 27:378-386(2009).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
-!- FUNCTION: Not yet known.
-!- SUBUNIT: Interacts with SECTM1. {ECO:0000269|PubMed:10652336}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X06180; CAA29546.1; -; mRNA.
EMBL; M37271; AAA51953.1; -; Genomic_DNA.
EMBL; BT006696; AAP35342.1; -; mRNA.
EMBL; BC009293; AAH09293.1; -; mRNA.
EMBL; BC013297; AAH13297.1; -; mRNA.
EMBL; D00749; BAA00646.1; -; Genomic_DNA.
CCDS; CCDS11807.1; -.
PIR; A39016; A39016.
RefSeq; NP_006128.1; NM_006137.6.
UniGene; Hs.36972; -.
ProteinModelPortal; P09564; -.
SMR; P09564; -.
BioGrid; 107362; 8.
IntAct; P09564; 5.
MINT; P09564; -.
STRING; 9606.ENSP00000312027; -.
iPTMnet; P09564; -.
PhosphoSitePlus; P09564; -.
SwissPalm; P09564; -.
BioMuta; CD7; -.
DMDM; 116031; -.
PaxDb; P09564; -.
PeptideAtlas; P09564; -.
PRIDE; P09564; -.
ProteomicsDB; 52247; -.
DNASU; 924; -.
Ensembl; ENST00000312648; ENSP00000312027; ENSG00000173762.
GeneID; 924; -.
KEGG; hsa:924; -.
CTD; 924; -.
DisGeNET; 924; -.
EuPathDB; HostDB:ENSG00000173762.7; -.
GeneCards; CD7; -.
HGNC; HGNC:1695; CD7.
HPA; CAB002594; -.
HPA; HPA039079; -.
MIM; 186820; gene.
neXtProt; NX_P09564; -.
OpenTargets; ENSG00000173762; -.
PharmGKB; PA26234; -.
eggNOG; ENOG410IYNZ; Eukaryota.
eggNOG; ENOG41117EQ; LUCA.
GeneTree; ENSGT00390000013965; -.
HOGENOM; HOG000285979; -.
HOVERGEN; HBG005290; -.
InParanoid; P09564; -.
KO; K06457; -.
OMA; YEDMSHS; -.
OrthoDB; EOG091G0Q1Y; -.
PhylomeDB; P09564; -.
TreeFam; TF338565; -.
SignaLink; P09564; -.
GeneWiki; CD7; -.
GenomeRNAi; 924; -.
PRO; PR:P09564; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000173762; -.
CleanEx; HS_CD7; -.
ExpressionAtlas; P09564; baseline and differential.
Genevisible; P09564; HS.
GO; GO:0016021; C:integral component of membrane; TAS:UniProtKB.
GO; GO:0016020; C:membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
GO; GO:0038023; F:signaling receptor activity; TAS:UniProtKB.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0006955; P:immune response; TAS:UniProtKB.
GO; GO:0042110; P:T cell activation; TAS:UniProtKB.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; NAS:UniProtKB.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 1.
SMART; SM00406; IGv; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS50835; IG_LIKE; 1.
1: Evidence at protein level;
Adaptive immunity; Complete proteome; Disulfide bond; Glycoprotein;
Immunity; Immunoglobulin domain; Lipoprotein; Membrane; Palmitate;
Polymorphism; Receptor; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 25
CHAIN 26 240 T-cell antigen CD7.
/FTId=PRO_0000014633.
TOPO_DOM 26 180 Extracellular.
{ECO:0000305|PubMed:2479685}.
TRANSMEM 181 201 Helical. {ECO:0000305}.
TOPO_DOM 202 240 Cytoplasmic.
{ECO:0000305|PubMed:2479685}.
DOMAIN 26 130 Ig-like.
REPEAT 145 153 1.
REPEAT 154 162 2.
REPEAT 163 171 3.
REPEAT 172 180 4.
REGION 145 180 4 X 9 AA tandem repeats, potential spacer
function.
LIPID 198 198 S-palmitoyl cysteine.
{ECO:0000305|PubMed:3501369}.
CARBOHYD 45 45 N-linked (GlcNAc...) asparagine.
CARBOHYD 96 96 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:19159218,
ECO:0000269|PubMed:19349973}.
DISULFID 35 142 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 48 114 {ECO:0000255|PROSITE-ProRule:PRU00114}.
VARIANT 113 113 T -> A (in dbSNP:rs34579511).
/FTId=VAR_049855.
SEQUENCE 240 AA; 25409 MW; EBBCE08279552108 CRC64;
MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR
QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV
NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP
AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ


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