Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

T-cell receptor-associated transmembrane adapter 1 (T-cell receptor-interacting molecule) (TRIM) (pp29/30)

 TRAT1_HUMAN             Reviewed;         186 AA.
Q6PIZ9; Q9NZX5;
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
18-JUL-2018, entry version 117.
RecName: Full=T-cell receptor-associated transmembrane adapter 1;
AltName: Full=T-cell receptor-interacting molecule;
Short=TRIM;
AltName: Full=pp29/30;
Name=TRAT1; Synonyms=TCRIM; ORFNames=HSPC062;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 152-167,
IDENTIFICATION BY MASS SPECTROMETRY, DIMERIZATION, INTERACTION WITH
THE TCR COMPLEX AND PIK3R1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
PHOSPHORYLATION AT TYR-79, SUBCELLULAR LOCATION, AND MUTAGENESIS OF
TYR-79.
PubMed=9687533; DOI=10.1084/jem.188.3.561;
Bruyns E., Marie-Cardine A., Kirchgessner H., Sagolla K.,
Shevchenko A., Mann M., Autschbach F., Bensussan A., Meuer S.,
Schraven B.;
"T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-
linked dimer associated with the TCR-CD3-zeta complex, recruits
intracellular signaling proteins to the plasma membrane.";
J. Exp. Med. 188:561-575(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Umbilical cord blood;
PubMed=11042152; DOI=10.1101/gr.140200;
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
"Cloning and functional analysis of cDNAs with open reading frames for
300 previously undefined genes expressed in CD34+ hematopoietic
stem/progenitor cells.";
Genome Res. 10:1546-1560(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, AND INTERACTION WITH CD3Z.
PubMed=11390434; DOI=10.1084/jem.193.11.1269;
Kirchgessner H., Dietrich J., Scherer J., Isomaeki P., Korinek V.,
Hilgert I., Bruyns E., Leo A., Cope A.P., Schraven B.;
"The transmembrane adaptor protein TRIM regulates T-cell receptor
(TCR) expression and TCR-mediated signaling via an association with
the TCR zeta chain.";
J. Exp. Med. 193:1269-1284(2001).
[5]
TISSUE SPECIFICITY.
PubMed=16160011; DOI=10.1182/blood-2005-06-2273;
Tedoldi S., Paterson J.C., Hansmann M.-L., Natkunam Y., Rudiger T.,
Angelisova P., Du M.Q., Roberton H., Roncador G., Sanchez L.,
Pozzobon M., Masir N., Barry R., Pileri S., Mason D.Y., Marafioti T.,
Horejsi V.;
"Transmembrane adaptor molecules: a new category of lymphoid-cell
markers.";
Blood 107:213-221(2006).
-!- FUNCTION: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex
at the surface of T-cells. {ECO:0000269|PubMed:11390434}.
-!- SUBUNIT: Homodimer; disulfide-linked. Interacts with CD3Z. When
phosphorylated, interacts with PIK3R1.
{ECO:0000269|PubMed:11390434, ECO:0000269|PubMed:9687533}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9687533};
Single-pass type III membrane protein
{ECO:0000269|PubMed:9687533}.
-!- TISSUE SPECIFICITY: Strongly expressed in thymus, and to a lesser
extent in spleen, lymph node and peripheral blood lymphocytes.
Present in T-cells and NK cells, but not B-cells (at protein
level). {ECO:0000269|PubMed:16160011, ECO:0000269|PubMed:9687533}.
-!- DEVELOPMENTAL STAGE: Strongly expressed in fetal thymus at weeks
17-24 of gestation. Undetectable in bone marrow and fetal liver.
{ECO:0000269|PubMed:9687533}.
-!- PTM: Phosphorylated on tyrosines by LCK or FYN upon TCR
activation. {ECO:0000269|PubMed:9687533}.
-!- SEQUENCE CAUTION:
Sequence=AAF29034.1; Type=Frameshift; Positions=166; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF161547; AAF29034.1; ALT_FRAME; mRNA.
EMBL; BC025713; AAH25713.1; -; mRNA.
CCDS; CCDS33813.1; -.
RefSeq; NP_001304676.1; NM_001317747.1.
RefSeq; NP_057472.2; NM_016388.3.
UniGene; Hs.138701; -.
ProteinModelPortal; Q6PIZ9; -.
BioGrid; 119154; 16.
IntAct; Q6PIZ9; 1.
STRING; 9606.ENSP00000295756; -.
iPTMnet; Q6PIZ9; -.
PhosphoSitePlus; Q6PIZ9; -.
BioMuta; TRAT1; -.
DMDM; 74749223; -.
MaxQB; Q6PIZ9; -.
PaxDb; Q6PIZ9; -.
PeptideAtlas; Q6PIZ9; -.
PRIDE; Q6PIZ9; -.
ProteomicsDB; 67189; -.
DNASU; 50852; -.
Ensembl; ENST00000295756; ENSP00000295756; ENSG00000163519.
GeneID; 50852; -.
KEGG; hsa:50852; -.
UCSC; uc003dxi.2; human.
CTD; 50852; -.
DisGeNET; 50852; -.
EuPathDB; HostDB:ENSG00000163519.13; -.
GeneCards; TRAT1; -.
HGNC; HGNC:30698; TRAT1.
HPA; CAB026130; -.
HPA; HPA002356; -.
MIM; 604962; gene.
neXtProt; NX_Q6PIZ9; -.
OpenTargets; ENSG00000163519; -.
PharmGKB; PA128394655; -.
eggNOG; ENOG410IW4V; Eukaryota.
eggNOG; ENOG410ZB8K; LUCA.
GeneTree; ENSGT00390000004910; -.
HOGENOM; HOG000129918; -.
HOVERGEN; HBG083932; -.
InParanoid; Q6PIZ9; -.
OMA; PVDENCY; -.
OrthoDB; EOG091G0RRV; -.
PhylomeDB; Q6PIZ9; -.
TreeFam; TF336066; -.
Reactome; R-HSA-1257604; PIP3 activates AKT signaling.
Reactome; R-HSA-202424; Downstream TCR signaling.
Reactome; R-HSA-2219530; Constitutive Signaling by Aberrant PI3K in Cancer.
Reactome; R-HSA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLink; Q6PIZ9; -.
GeneWiki; TRAT1; -.
GenomeRNAi; 50852; -.
PRO; PR:Q6PIZ9; -.
Proteomes; UP000005640; Chromosome 3.
Bgee; ENSG00000163519; -.
CleanEx; HS_TRAT1; -.
ExpressionAtlas; Q6PIZ9; baseline and differential.
Genevisible; Q6PIZ9; HS.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0042101; C:T cell receptor complex; IDA:MGI.
GO; GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome.
GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; TAS:ProtInc.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
GO; GO:0001920; P:negative regulation of receptor recycling; IDA:MGI.
GO; GO:0051051; P:negative regulation of transport; IDA:MGI.
GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IDA:MGI.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; TAS:Reactome.
GO; GO:0050862; P:positive regulation of T cell receptor signaling pathway; IDA:MGI.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
GO; GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
InterPro; IPR020399; T-cell_rcpt-assoc_TM_adapter-1.
PANTHER; PTHR15951; PTHR15951; 1.
ProDom; PD306446; T-cell_rcpt-assoc_TM_adapter-1; 1.
1: Evidence at protein level;
Adaptive immunity; Cell membrane; Complete proteome;
Direct protein sequencing; Disulfide bond; Immunity; Membrane;
Phosphoprotein; Polymorphism; Reference proteome; Signal-anchor;
Transmembrane; Transmembrane helix.
CHAIN 1 186 T-cell receptor-associated transmembrane
adapter 1.
/FTId=PRO_0000083344.
TOPO_DOM 1 7 Extracellular. {ECO:0000255}.
TRANSMEM 8 28 Helical; Signal-anchor for type III
membrane protein. {ECO:0000255}.
TOPO_DOM 29 186 Cytoplasmic. {ECO:0000255}.
REGION 79 82 Interaction with PIK3R1.
{ECO:0000269|PubMed:9687533}.
MOD_RES 46 46 Phosphoserine.
{ECO:0000250|UniProtKB:Q3UU67}.
MOD_RES 79 79 Phosphotyrosine.
{ECO:0000305|PubMed:9687533}.
DISULFID 7 7 Interchain. {ECO:0000305}.
VARIANT 137 137 D -> G (in dbSNP:rs57744779).
/FTId=VAR_062195.
VARIANT 148 148 S -> P (in dbSNP:rs61585973).
/FTId=VAR_062196.
MUTAGEN 79 79 Y->F: Abolishes interaction with PIK3R1.
{ECO:0000269|PubMed:9687533}.
SEQUENCE 186 AA; 21211 MW; 236A4BEFF427EA3E CRC64;
MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT RVDEYYIEDT
PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA QATNETQMCY ASLDHSVKGK
RRKPRKQNTH FSDKDGDEQL HAIDASVSKT TLVDSFSPES QAVEENIHDD PIRLFGLIRA
KREPIN


Related products :

Catalog number Product name Quantity
EIAAB43796 Mouse,Mus musculus,T-cell receptor-associated transmembrane adapter 1,T-cell receptor-interacting molecule,Trat1,TRIM
EIAAB43798 Bos taurus,Bovine,T-cell receptor-associated transmembrane adapter 1,T-cell receptor-interacting molecule,TRAT1,TRIM
EIAAB43797 Homo sapiens,HSPC062,Human,pp29_30,T-cell receptor-associated transmembrane adapter 1,T-cell receptor-interacting molecule,TCRIM,TRAT1,TRIM
CF17 Recombinant Human T Cell Receptor Interacting Molecule per TRIM per TCRIM per TRAT1 (C-6His) 10ug
CF17 T-Cell Receptor-Associated Transmembrane Adapter 1 TRAT1 lmg
CF17 T-Cell Receptor-Associated Transmembrane Adapter 1 TRAT1 500
CC99 Human T-Cell Receptor-Associated Transmembrane Adapter 1 TRAT1 l0
E1757r Human ELISA Kit FOR T-cell receptor-associated transmembrane adapter 1 96T
C578 Human T-Cell Receptor-Associated Transmembrane Adapter 1 TRAT1 50
CF17 Recombinant Human T-Cell Receptor-Associated Transmembrane Adapter 1_TRAT1 10 ug
CSB-EL024235BO Bovine T-cell receptor-associated transmembrane adapter 1(TRAT1) ELISA kit 96T
CSB-EL024235HU Human T-cell receptor-associated transmembrane adapter 1(TRAT1) ELISA kit 96T
H4306 T-cell receptor-associated transmembrane adapter 1 (TRAT1), Human, ELISA Kit 96T
H4307 T-cell receptor-associated transmembrane adapter 1 (TRAT1), Mouse, ELISA Kit 96T
CF17 Recombinant Human T-Cell Receptor-Associated Transmembrane Adapter 1_TRAT1 1 mg
CF17 Recombinant Human T-Cell Receptor-Associated Transmembrane Adapter 1_TRAT1 500 ug
H4305 T-cell receptor-associated transmembrane adapter 1 (TRAT1), Bovine, ELISA Kit 96T
CF17 Recombinant Human T-Cell Receptor-Associated Transmembrane Adapter 1_TRAT1 50 ug
CSB-EL024235MO Mouse T-cell receptor-associated transmembrane adapter 1(TRAT1) ELISA kit 96T
CSB-EL024235MO Mouse T-cell receptor-associated transmembrane adapter 1(TRAT1) ELISA kit SpeciesMouse 96T
CSB-EL024235HU Human T-cell receptor-associated transmembrane adapter 1(TRAT1) ELISA kit SpeciesHuman 96T
CSB-EL024235BO Bovine T-cell receptor-associated transmembrane adapter 1(TRAT1) ELISA kit SpeciesBovine 96T
TRAT1_MOUSE ELISA Kit FOR T-cell receptor-associated transmembrane adapter 1; organism: Mouse; gene name: Trat1 96T
EIAAB38520 Rat,Rattus norvegicus,SHP2-interacting transmembrane adapter protein,Signaling threshold-regulating transmembrane adapter 1,Sit,Sit1,Suppression-inducing transmembrane adapter 1
EIAAB38519 Mouse,Mus musculus,SHP2-interacting transmembrane adapter protein,Signaling threshold-regulating transmembrane adapter 1,Sit,Sit1,Suppression-inducing transmembrane adapter 1


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur