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T-cell surface antigen CD2

 F7DS86_MACMU            Unreviewed;       351 AA.
F7DS86;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
30-AUG-2017, entry version 42.
SubName: Full=CD2 molecule {ECO:0000313|Ensembl:ENSMMUP00000057424};
SubName: Full=T-cell surface antigen CD2 {ECO:0000313|EMBL:AFH34587.1};
Name=CD2 {ECO:0000313|EMBL:AFH34587.1,
ECO:0000313|Ensembl:ENSMMUP00000057424};
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000057424, ECO:0000313|Proteomes:UP000006718};
[1] {ECO:0000313|Ensembl:ENSMMUP00000057424, ECO:0000313|Proteomes:UP000006718}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000057424,
ECO:0000313|Proteomes:UP000006718};
PubMed=17431167; DOI=10.1126/science.1139247;
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
Zwieg A.S.;
"Evolutionary and biomedical insights from the rhesus macaque
genome.";
Science 316:222-234(2007).
[2] {ECO:0000313|EMBL:AFH34587.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Thymus {ECO:0000313|EMBL:AFH34587.1};
PubMed=25319552; DOI=10.1186/1745-6150-9-20;
Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X.,
Pandey S., Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P.,
Tharp G.K., Marcais G., Roberts M., Ferguson B., Fox H.S.,
Treangen T., Salzberg S.L., Yorke J.A., Norgren R.B.Jr.;
"A new rhesus macaque assembly and annotation for next-generation
sequencing analyses.";
Biol. Direct 9:20-20(2014).
[3] {ECO:0000313|Ensembl:ENSMMUP00000057424}
IDENTIFICATION.
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000057424};
Ensembl;
Submitted (OCT-2016) to UniProtKB.
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EMBL; JSUE03002251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; JU477783; AFH34587.1; -; mRNA.
RefSeq; NP_001182402.1; NM_001195473.1.
UniGene; Mmu.9828; -.
STRING; 9544.ENSMMUP00000016101; -.
Ensembl; ENSMMUT00000054237; ENSMMUP00000057424; ENSMMUG00000045754.
GeneID; 677855; -.
KEGG; mcc:677855; -.
CTD; 914; -.
eggNOG; ENOG410IW98; Eukaryota.
eggNOG; ENOG410Y7BE; LUCA.
GeneTree; ENSGT00390000009232; -.
KO; K06449; -.
OMA; GTQVHQQ; -.
OrthoDB; EOG091G0M7A; -.
TreeFam; TF335971; -.
Proteomes; UP000006718; Chromosome 1.
Bgee; ENSMMUG00000012272; -.
GO; GO:0046658; C:anchored component of plasma membrane; IEA:Ensembl.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005576; C:extracellular region; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0005102; F:receptor binding; IEA:Ensembl.
GO; GO:0034113; P:heterotypic cell-cell adhesion; IEA:Ensembl.
GO; GO:1902715; P:positive regulation of interferon-gamma secretion; IEA:Ensembl.
GO; GO:2000484; P:positive regulation of interleukin-8 secretion; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR015632; CD2.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR008424; Ig_C2-set.
InterPro; IPR013106; Ig_V-set.
Pfam; PF05790; C2-set; 1.
Pfam; PF07686; V-set; 1.
PRINTS; PR01870; CD2ANTIGEN.
SUPFAM; SSF48726; SSF48726; 2.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000006718};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000006718};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 24 {ECO:0000256|SAM:SignalP}.
CHAIN 25 351 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5010832719.
TRANSMEM 210 234 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 32 126 IGv. {ECO:0000259|Pfam:PF07686}.
DOMAIN 135 205 C2-set. {ECO:0000259|Pfam:PF05790}.
SEQUENCE 351 AA; 39542 MW; A098E420D4EA3BFE CRC64;
MSLPCKIVTS FLLIFNVSSK GAVSKEIRNA LETWGALGQD IDLDIPSFQM SDDIDDIRWE
KTSDKKKIAQ FRKEKETFEE KDAYKLFKNG TLKIKHLKIH DQDSYKVSIY DTKGKNVLEK
TFDLKIQERV SEPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHVKLSQR VITHKWTTSL
SAKFKCTAGN KVSKESRMET VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ
RSRRNDEELE IRAHRVATEE RGRKPHQIPA STPQNPAASQ HPPPPPGHRS QAPSHRPLPP
GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPQG AAENSLSPSS N


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