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T-cell surface antigen CD2 (LFA-2) (LFA-3 receptor) (Lymphocyte antigen 37) (Ly-37) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

 CD2_MOUSE               Reviewed;         344 AA.
P08920; Q61394;
01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
01-NOV-1988, sequence version 1.
25-OCT-2017, entry version 165.
RecName: Full=T-cell surface antigen CD2;
AltName: Full=LFA-2;
AltName: Full=LFA-3 receptor;
AltName: Full=Lymphocyte antigen 37;
Short=Ly-37;
AltName: Full=T-cell surface antigen T11/Leu-5;
AltName: CD_antigen=CD2;
Flags: Precursor;
Name=Cd2; Synonyms=Ly-37;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=B10.A;
PubMed=2440689; DOI=10.1002/eji.1830170718;
Sewell W.A., Brown M.H., Fink P.J., Kozak C.A., Crumpton M.J.;
"The murine homologue of the T lymphocyte CD2 antigen: molecular
cloning, chromosome assignment and cell surface expression.";
Eur. J. Immunol. 17:1015-1020(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2820751; DOI=10.1002/eji.1830170922;
Clayton L.K., Sayre P.H., Novotny J., Reinherz E.L.;
"Murine and human T11 (CD2) cDNA sequences suggest a common signal
transduction mechanism.";
Eur. J. Immunol. 17:1367-1370(1987).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=BALB/cJ; TISSUE=Liver;
PubMed=2894031; DOI=10.1073/pnas.85.5.1615;
Diamond D.J., Clayton L.K., Sayre P.H., Reinherz E.L.;
"Exon-intron organization and sequence comparison of human and murine
T11 (CD2) genes.";
Proc. Natl. Acad. Sci. U.S.A. 85:1615-1619(1988).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3257775;
Yagita H., Okumura K., Nakauchi H.;
"Molecular cloning of the murine homologue of CD2. Homology of the
molecule to its human counterpart T11.";
J. Immunol. 140:1321-1326(1988).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Hematopoietic;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
INTERACTION WITH CD2AP.
PubMed=9741631; DOI=10.1016/S0092-8674(00)81608-6;
Dustin M.L., Olszowy M.W., Holdorf A.D., Li J., Bromley S., Desai N.,
Widder P., Rosenberger F., van der Merwe P.A., Allen P.M., Shaw A.S.;
"A novel adaptor protein orchestrates receptor patterning and
cytoskeletal polarity in T-cell contacts.";
Cell 94:667-677(1998).
[7]
INTERACTION WITH PSTPIP1.
PubMed=12530983; DOI=10.1016/S1074-7613(02)00516-2;
Badour K., Zhang J., Shi F., McGavin M.K.H., Rampersad V., Hardy L.A.,
Field D., Siminovitch K.A.;
"The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the
CD2AP and PSTPIP1 adaptors to promote formation of the immunological
synapse.";
Immunity 18:141-154(2003).
-!- FUNCTION: CD2 interacts with lymphocyte function-associated
antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells
and other cell types. CD2 is implicated in the triggering of T-
cells, the cytoplasmic domain is implicated in the signaling
function.
-!- SUBUNIT: Interacts with CD2AP and PSTPIP1.
{ECO:0000269|PubMed:12530983, ECO:0000269|PubMed:9741631}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; Y00023; CAA68258.1; -; mRNA.
EMBL; X06143; CAA29500.1; -; mRNA.
EMBL; M19807; AAA37393.1; -; Genomic_DNA.
EMBL; M19799; AAA37393.1; JOINED; Genomic_DNA.
EMBL; M19801; AAA37393.1; JOINED; Genomic_DNA.
EMBL; M19803; AAA37393.1; JOINED; Genomic_DNA.
EMBL; M19805; AAA37393.1; JOINED; Genomic_DNA.
EMBL; M18934; AAA37397.1; -; mRNA.
EMBL; BC053731; AAH53731.1; -; mRNA.
CCDS; CCDS17681.1; -.
PIR; I49585; I49585.
RefSeq; NP_038514.1; NM_013486.2.
UniGene; Mm.22842; -.
ProteinModelPortal; P08920; -.
SMR; P08920; -.
IntAct; P08920; 1.
MINT; MINT-1769762; -.
STRING; 10090.ENSMUSP00000029456; -.
PhosphoSitePlus; P08920; -.
EPD; P08920; -.
PaxDb; P08920; -.
PRIDE; P08920; -.
Ensembl; ENSMUST00000029456; ENSMUSP00000029456; ENSMUSG00000027863.
GeneID; 12481; -.
KEGG; mmu:12481; -.
UCSC; uc008qrf.1; mouse.
CTD; 914; -.
MGI; MGI:88320; Cd2.
eggNOG; ENOG410IW98; Eukaryota.
eggNOG; ENOG410Y7BE; LUCA.
GeneTree; ENSGT00390000009232; -.
HOGENOM; HOG000276890; -.
HOVERGEN; HBG000262; -.
InParanoid; P08920; -.
KO; K06449; -.
OMA; GTQVHQQ; -.
OrthoDB; EOG091G0M7A; -.
PhylomeDB; P08920; -.
TreeFam; TF335971; -.
PRO; PR:P08920; -.
Proteomes; UP000000589; Chromosome 3.
Bgee; ENSMUSG00000027863; -.
CleanEx; MM_CD2; -.
ExpressionAtlas; P08920; baseline and differential.
Genevisible; P08920; MM.
GO; GO:0046658; C:anchored component of plasma membrane; IDA:MGI.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0005911; C:cell-cell junction; IDA:MGI.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IDA:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005576; C:extracellular region; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042803; F:protein homodimerization activity; IDA:MGI.
GO; GO:0005102; F:receptor binding; ISO:MGI.
GO; GO:0034113; P:heterotypic cell-cell adhesion; ISO:MGI.
GO; GO:1902715; P:positive regulation of interferon-gamma secretion; ISO:MGI.
GO; GO:2000484; P:positive regulation of interleukin-8 secretion; ISO:MGI.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:MGI.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR015632; CD2.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR008424; Ig_C2-set.
InterPro; IPR013106; Ig_V-set.
Pfam; PF05790; C2-set; 1.
Pfam; PF07686; V-set; 1.
PRINTS; PR01870; CD2ANTIGEN.
SUPFAM; SSF48726; SSF48726; 2.
1: Evidence at protein level;
Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 22
CHAIN 23 344 T-cell surface antigen CD2.
/FTId=PRO_0000014602.
TOPO_DOM 23 203 Extracellular. {ECO:0000255}.
TRANSMEM 204 229 Helical. {ECO:0000255}.
TOPO_DOM 230 344 Cytoplasmic. {ECO:0000255}.
DOMAIN 23 121 Ig-like V-type.
DOMAIN 122 202 Ig-like C2-type.
COMPBIAS 276 343 Pro-rich.
CARBOHYD 82 82 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 94 94 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 135 135 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 166 166 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 133 197 {ECO:0000250|UniProtKB:P08921}.
DISULFID 140 180 {ECO:0000250|UniProtKB:P08921}.
CONFLICT 99 99 Y -> T (in Ref. 3). {ECO:0000305}.
CONFLICT 128 128 M -> V (in Ref. 3 and 4). {ECO:0000305}.
CONFLICT 139 139 T -> I (in Ref. 4; AAA37397).
{ECO:0000305}.
CONFLICT 175 175 N -> A (in Ref. 3). {ECO:0000305}.
CONFLICT 175 175 N -> S (in Ref. 4; AAA37393/AAA37397).
{ECO:0000305}.
CONFLICT 191 191 K -> N (in Ref. 2; CAA29500).
{ECO:0000305}.
CONFLICT 192 192 M -> T (in Ref. 3 and 4). {ECO:0000305}.
SEQUENCE 344 AA; 38415 MW; CFD12FCBD1444450 CRC64;
MKCKFLGSFF LLFSLSGKGA DCRDNETIWG VLGHGITLNI PNFQMTDDID EVRWVRRGTL
VAEFKRKKPP FLISETYEVL ANGSLKIKKP MMRNDSGTYN VMVYGTNGMT RLEKDLDVRI
LERVSKPMIH WECPNTTLTC AVLQGTDFEL KLYQGETLLN SLPQKNMSYQ WTNLNAPFKC
EAINPVSKES KMEVVNCPEK GLSFYVTVGV GAGGLLLVLL VALFIFCICK RRKRNRRRKD
EELEIKASRT STVERGPKPH STPAAAAQNS VALQAPPPPG HHLQTPGHRP LPPGHRTREH
QQKKRPPPSG TQIHQQKGPP LPRPRVQPKP PCGSGDGVSL PPPN


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