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T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)

 CD3D_PIG                Reviewed;         171 AA.
29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
16-JAN-2019, entry version 101.
RecName: Full=T-cell surface glycoprotein CD3 delta chain;
AltName: Full=T-cell receptor T3 delta chain;
AltName: CD_antigen=CD3d;
Flags: Precursor;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Yang H., Wileman T.;
"Structural differences between the CD3 molecules expressed at the
surface of alpha beta- and gamma delta-T cells revealed by monoclonal
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
PubMed=14681463; DOI=10.1093/nar/gkh037;
Uenishi H., Eguchi T., Suzuki K., Sawazaki T., Toki D., Shinkai H.,
Okumura N., Hamasima N., Awata T.;
"PEDE (Pig EST Data Explorer): construction of a database for ESTs
derived from porcine full-length cDNA libraries.";
Nucleic Acids Res. 32:D484-D488(2004).
-!- FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell
surface that plays an essential role in adaptive immune response.
When antigen presenting cells (APCs) activate T-cell receptor
(TCR), TCR-mediated signals are transmitted across the cell
membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3
chains contain immunoreceptor tyrosine-based activation motifs
(ITAMs) in their cytoplasmic domain. Upon TCR engagement, these
motifs become phosphorylated by Src family protein tyrosine
kinases LCK and FYN, resulting in the activation of downstream
signaling pathways. In addition of this role of signal
transduction in T-cell activation, CD3D plays an essential role in
thymocyte differentiation. Indeed, participates in correct
intracellular TCR-CD3 complex assembly and surface expression. In
absence of a functional TCR-CD3 complex, thymocytes are unable to
differentiate properly. Interacts with CD4 and CD8 and thus serves
to establish a functional link between the TCR and coreceptors CD4
and CD8, which is needed for activation and positive selection of
CD4 or CD8 T-cells. {ECO:0000250|UniProtKB:P04234}.
-!- SUBUNIT: The TCR-CD3 complex is composed of a CD3D/CD3E and a
CD3G/CD3E heterodimers that preferentially associate with TCRalpha
and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and
TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with
CD3Z homodimer to form the TCR-CD3 complex. Alternatively,
TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
Interacts with coreceptors CD4 and CD8.
{ECO:0000250|UniProtKB:P04234}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P04234}.
-!- TISSUE SPECIFICITY: CD3D is mostly present on T-lymphocytes with
its TCR-CD3 partners. Present also in fetal NK-cells.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AY823637; AAV80703.1; -; mRNA.
EMBL; AB116557; BAD06311.1; -; mRNA.
RefSeq; NP_998940.1; NM_213775.2.
UniGene; Ssc.19673; -.
ProteinModelPortal; Q764N2; -.
SMR; Q764N2; -.
IntAct; Q764N2; 1.
STRING; 9823.ENSSSCP00000028968; -.
PaxDb; Q764N2; -.
PRIDE; Q764N2; -.
Ensembl; ENSSSCT00000034310; ENSSSCP00000028968; ENSSSCG00000015093.
GeneID; 396661; -.
KEGG; ssc:396661; -.
CTD; 915; -.
eggNOG; ENOG410IWAX; Eukaryota.
GeneTree; ENSGT00940000153312; -.
HOGENOM; HOG000015287; -.
HOVERGEN; HBG005278; -.
InParanoid; Q764N2; -.
KO; K06450; -.
OrthoDB; 1466902at2759; -.
TreeFam; TF335892; -.
Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Reactome; R-SSC-202424; Downstream TCR signaling.
Reactome; R-SSC-202427; Phosphorylation of CD3 and TCR zeta chains.
Reactome; R-SSC-202430; Translocation of ZAP-70 to Immunological synapse.
Reactome; R-SSC-202433; Generation of second messenger molecules.
Reactome; R-SSC-389948; PD-1 signaling.
Reactome; R-SSC-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-SSC-8856828; Clathrin-mediated endocytosis.
Proteomes; UP000008227; Chromosome 9.
Bgee; ENSSSCG00000015093; Expressed in 5 organ(s), highest expression level in lung.
ExpressionAtlas; Q764N2; baseline and differential.
Genevisible; Q764N2; SS.
GO; GO:0042105; C:alpha-beta T cell receptor complex; IBA:GO_Central.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0045059; P:positive thymic T cell selection; IBA:GO_Central.
GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO; GO:0030217; P:T cell differentiation; IBA:GO_Central.
Gene3D;; -; 1.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR015485; CD3D.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR032052; Ig_4.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
PANTHER; PTHR10570:SF5; PTHR10570:SF5; 1.
Pfam; PF16680; Ig_4; 1.
Pfam; PF02189; ITAM; 1.
SMART; SM00077; ITAM; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS51055; ITAM_1; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunity; Membrane; Phosphoprotein; Receptor;
Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 171 T-cell surface glycoprotein CD3 delta
TOPO_DOM 22 104 Extracellular. {ECO:0000255}.
TRANSMEM 105 125 Helical. {ECO:0000255}.
TOPO_DOM 126 171 Cytoplasmic. {ECO:0000255}.
DOMAIN 138 166 ITAM. {ECO:0000255|PROSITE-
MOD_RES 149 149 Phosphotyrosine.
MOD_RES 160 160 Phosphotyrosine.
CARBOHYD 38 38 N-linked (GlcNAc...) asparagine.
DISULFID 37 72 {ECO:0000250}.
SEQUENCE 171 AA; 19475 MW; 553EC39066C0E78C CRC64;

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