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T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)

 CD3D_MACFA              Reviewed;         171 AA.
Q95LI8;
23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
22-NOV-2017, entry version 72.
RecName: Full=T-cell surface glycoprotein CD3 delta chain;
AltName: Full=T-cell receptor T3 delta chain;
AltName: CD_antigen=CD3d;
Flags: Precursor;
Name=CD3D;
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11515669;
Uda A., Tanabayashi K., Mukai R., Yachi M., Nam K., Yamada A.;
"CD3 polymorphism in cynomolgus monkeys (Macaca fascicularis).";
J. Med. Primatol. 30:141-147(2001).
-!- FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell
surface that plays an essential role in adaptive immune response.
When antigen presenting cells (APCs) activate T-cell receptor
(TCR), TCR-mediated signals are transmitted across the cell
membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3
chains contain immunoreceptor tyrosine-based activation motifs
(ITAMs) in their cytoplasmic domain. Upon TCR engagement, these
motifs become phosphorylated by Src family protein tyrosine
kinases LCK and FYN, resulting in the activation of downstream
signaling pathways. In addition of this role of signal
transduction in T-cell activation, CD3D plays an essential role in
thymocyte differentiation. Indeed, participates in correct
intracellular TCR-CD3 complex assembly and surface expression. In
absence of a functional TCR-CD3 complex, thymocytes are unable to
differentiate properly. Interacts with CD4 and CD8 and thus serves
to establish a functional link between the TCR and coreceptors CD4
and CD8, which is needed for activation and positive selection of
CD4 or CD8 T-cells. {ECO:0000250|UniProtKB:P04234}.
-!- SUBUNIT: The TCR-CD3 complex is composed of a CD3D/CD3E and a
CD3G/CD3E heterodimers that preferentially associate with TCRalpha
and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and
TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with
CD3Z homodimer to form the TCR-CD3 complex. Alternatively,
TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
Interacts with coreceptors CD4 and CD8.
{ECO:0000250|UniProtKB:P04234}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P04234}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P04234}.
-!- TISSUE SPECIFICITY: CD3D is mostly present on T-lymphocytes with
its TCR-CD3 partners. Present also in fetal NK-cells.
{ECO:0000250|UniProtKB:P04234}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8.
{ECO:0000250|UniProtKB:P04234}.
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EMBL; AB073991; BAB71847.1; -; mRNA.
RefSeq; NP_001274617.1; NM_001287688.1.
UniGene; Mfa.6115; -.
ProteinModelPortal; Q95LI8; -.
SMR; Q95LI8; -.
GeneID; 102133701; -.
KEGG; mcf:102133701; -.
CTD; 915; -.
HOVERGEN; HBG005278; -.
KO; K06450; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042101; C:T cell receptor complex; IEA:InterPro.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
GO; GO:0045059; P:positive thymic T cell selection; ISS:UniProtKB.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR015485; CD3D.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR032052; Ig_4.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
PANTHER; PTHR10570:SF5; PTHR10570:SF5; 1.
Pfam; PF16680; Ig_4; 1.
Pfam; PF02189; ITAM; 1.
SMART; SM00077; ITAM; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS51055; ITAM_1; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Disulfide bond; Glycoprotein;
Immunity; Membrane; Phosphoprotein; Receptor; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 21 {ECO:0000250}.
CHAIN 22 171 T-cell surface glycoprotein CD3 delta
chain.
/FTId=PRO_0000016488.
TOPO_DOM 22 105 Extracellular. {ECO:0000255}.
TRANSMEM 106 126 Helical. {ECO:0000255}.
TOPO_DOM 127 171 Cytoplasmic. {ECO:0000255}.
DOMAIN 138 166 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOD_RES 149 149 Phosphotyrosine.
{ECO:0000250|UniProtKB:P04234,
ECO:0000255|PROSITE-ProRule:PRU00379}.
MOD_RES 160 160 Phosphotyrosine.
{ECO:0000250|UniProtKB:P04234,
ECO:0000255|PROSITE-ProRule:PRU00379}.
CARBOHYD 38 38 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 54 54 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 74 74 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 37 73 {ECO:0000250}.
SEQUENCE 171 AA; 18960 MW; 9C48629081DDFF42 CRC64;
MEHSTFLSGL VLATLLSQVS PFKIPVEELE DRVFVKCNTS VTWVEGTVGT LLTNNTRLDL
GKRILDPRGI YRCNGTDIYK DKESAVQVHY RMCQNCVELD PATLAGIIVT DVIATLLLAL
GVFCFAGHET GRLSGAADTQ ALLRNDQVYQ PLRDRDDAQY SRLGGNWARN K


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