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T-cell surface glycoprotein CD3 epsilon chain (CD antigen CD3e)

 CD3E_CANLF              Reviewed;         202 AA.
P27597;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 1.
30-AUG-2017, entry version 112.
RecName: Full=T-cell surface glycoprotein CD3 epsilon chain;
AltName: CD_antigen=CD3e;
Flags: Precursor;
Name=CD3E;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1828779; DOI=10.1007/BF00216700;
Nash R.A., Scherf U., Storb R.;
"Molecular cloning of the CD3 epsilon subunit of the T-cell
receptor/CD3 complex in dog.";
Immunogenetics 33:396-398(1991).
-!- FUNCTION: The CD3 complex mediates signal transduction, resulting
in T-cell activation and proliferation. Required for normal immune
responses. {ECO:0000250|UniProtKB:P07766}.
-!- SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a
TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the
cell surface with the invariant subunits of CD3 labeled gamma,
delta, epsilon, zeta, and eta. Interacts with CD6.
{ECO:0000250|UniProtKB:P07766}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P07766}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P07766}.
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EMBL; M55410; AAA30834.1; -; mRNA.
PIR; I46195; I46195.
RefSeq; NP_001003379.1; NM_001003379.1.
UniGene; Cfa.3890; -.
ProteinModelPortal; P27597; -.
SMR; P27597; -.
STRING; 9615.ENSCAFP00000018835; -.
PaxDb; P27597; -.
Ensembl; ENSCAFT00000020302; ENSCAFP00000018835; ENSCAFG00000012802.
GeneID; 442981; -.
KEGG; cfa:442981; -.
CTD; 916; -.
eggNOG; ENOG410IYD1; Eukaryota.
eggNOG; ENOG41123JN; LUCA.
GeneTree; ENSGT00510000048592; -.
HOGENOM; HOG000290664; -.
HOVERGEN; HBG102121; -.
InParanoid; P27597; -.
KO; K06451; -.
OMA; QRGQNKE; -.
OrthoDB; EOG091G0PKE; -.
TreeFam; TF335892; -.
Proteomes; UP000002254; Chromosome 5.
Bgee; ENSCAFG00000012802; -.
GO; GO:0042105; C:alpha-beta T cell receptor complex; IEA:Ensembl.
GO; GO:0044297; C:cell body; IEA:Ensembl.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
GO; GO:0016358; P:dendrite development; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0045060; P:negative thymic T cell selection; IEA:Ensembl.
GO; GO:0046641; P:positive regulation of alpha-beta T cell proliferation; IEA:Ensembl.
GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0002669; P:positive regulation of T cell anergy; IEA:Ensembl.
GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO; GO:0031295; P:T cell costimulation; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
Pfam; PF02189; ITAM; 1.
SMART; SM00408; IGc2; 1.
SMART; SM00077; ITAM; 1.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS51055; ITAM_1; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Immunity;
Immunoglobulin domain; Membrane; Phosphoprotein; Receptor;
Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 202 T-cell surface glycoprotein CD3 epsilon
chain.
/FTId=PRO_0000014605.
TOPO_DOM 22 122 Extracellular. {ECO:0000255}.
TRANSMEM 123 143 Helical. {ECO:0000255}.
TOPO_DOM 144 202 Cytoplasmic. {ECO:0000255}.
DOMAIN 37 107 Ig-like.
DOMAIN 173 200 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOD_RES 183 183 Phosphotyrosine.
{ECO:0000250|UniProtKB:P07766,
ECO:0000255|PROSITE-ProRule:PRU00379}.
MOD_RES 194 194 Phosphotyrosine.
{ECO:0000250|UniProtKB:P07766,
ECO:0000255|PROSITE-ProRule:PRU00379}.
DISULFID 54 96 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 202 AA; 22642 MW; E5779E0A44B8316E CRC64;
MQSRNLWRIL GLCLLSVGAW GQDEDFKASD DLTSISPEKR FKVSISGTEV VVTCPDVFGY
DNIKWEKNDN LVEGASNREL SQKEFSEVDD SGYYACYADS IKEKSYLYLR ARVCANCIEV
NLMAVVTIIV ADICLTLGLL LMVYYWSKTR KANAKPVMRG TGAGSRPRGQ NKEKPPPVPN
PDYEPIRKGQ QDLYSGLNQR GI


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