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T-cell surface glycoprotein CD3 epsilon chain (CD antigen CD3e)

 CD3E_CHICK              Reviewed;         175 AA.
Q98910;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
12-APR-2017, entry version 95.
RecName: Full=T-cell surface glycoprotein CD3 epsilon chain;
AltName: CD_antigen=CD3e;
Flags: Precursor;
Name=CD3E;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=CB; TISSUE=Blood;
PubMed=9022018; DOI=10.1002/eji.1830270129;
Gobel T.W.F., Fluri M.;
"Identification and analysis of the chicken CD3epsilon gene.";
Eur. J. Immunol. 27:194-198(1997).
-!- FUNCTION: The CD3 complex mediates signal transduction, resulting
in T-cell activation and proliferation. Required for normal immune
responses. {ECO:0000250|UniProtKB:P07766}.
-!- SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a
TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the
cell surface with the invariant subunits of CD3 labeled gamma,
delta, epsilon, zeta, and eta. {ECO:0000250|UniProtKB:P07766}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P07766}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P07766}.
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EMBL; Y08917; CAA70121.1; -; mRNA.
UniGene; Gga.4970; -.
SMR; Q98910; -.
STRING; 9031.ENSGALP00000011982; -.
PaxDb; Q98910; -.
eggNOG; ENOG410IYD1; Eukaryota.
eggNOG; ENOG41123JN; LUCA.
HOGENOM; HOG000290664; -.
HOVERGEN; HBG102121; -.
InParanoid; Q98910; -.
PhylomeDB; Q98910; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
SMART; SM00077; ITAM; 1.
PROSITE; PS51055; ITAM_1; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Immunity; Immunoglobulin domain;
Membrane; Receptor; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 175 T-cell surface glycoprotein CD3 epsilon
chain.
/FTId=PRO_0000014613.
TOPO_DOM 22 100 Extracellular. {ECO:0000255}.
TRANSMEM 101 121 Helical. {ECO:0000255}.
TOPO_DOM 122 175 Cytoplasmic. {ECO:0000255}.
DOMAIN 146 173 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
SEQUENCE 175 AA; 19062 MW; 5D7F57E890D13B72 CRC64;
MRCEVPLPLL GLLLCVVGAA AQGGQEEFAV EISGTTVTIT CPSSGDDVKW KPDPKMVVNN
KYIIQNHDSS PLTVSCTAGD EEHTMYLNAK VCANCEELDT FTVVGIIAAD LLITLGVLIL
VYYFSKNKKG QSRAAAGSRP RAQKMRRPPP VPNPDYEPIR KGQRDVYAGL EHRGF


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