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T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)

 CD3E_MOUSE              Reviewed;         189 AA.
P22646;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 2.
27-SEP-2017, entry version 153.
RecName: Full=T-cell surface glycoprotein CD3 epsilon chain;
AltName: Full=T-cell surface antigen T3/Leu-4 epsilon chain;
AltName: CD_antigen=CD3e;
Flags: Precursor;
Name=Cd3e;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3478717; DOI=10.1073/pnas.84.21.7649;
Gold D.P., Clevers H., Alarcon B., Dunlap S., Novotny J.,
Williams A.F., Terhorst C.;
"Evolutionary relationship between the T3 chains of the T-cell
receptor complex and the immunoglobulin supergene family.";
Proc. Natl. Acad. Sci. U.S.A. 84:7649-7653(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2973066; DOI=10.1073/pnas.85.22.8623;
Clevers H., Dunlap S., Saito H., Georgopoulos K., Wileman T.,
Terhorst C.;
"Characterization and expression of the murine CD3-epsilon gene.";
Proc. Natl. Acad. Sci. U.S.A. 85:8623-8627(1988).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[4]
STRUCTURE BY NMR OF 22-100, AND DISULFIDE BONDS.
PubMed=11439187; DOI=10.1016/S0092-8674(01)00395-6;
Sun Z.J., Kim K.S., Wagner G., Reinherz E.L.;
"Mechanisms contributing to T cell receptor signaling and assembly
revealed by the solution structure of an ectodomain fragment of the
CD3 epsilon gamma heterodimer.";
Cell 105:913-923(2001).
-!- FUNCTION: The CD3 complex mediates signal transduction, resulting
in T-cell activation and proliferation. Required for normal immune
responses. {ECO:0000250|UniProtKB:P07766}.
-!- SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a
TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the
cell surface with the invariant subunits of CD3 labeled gamma,
delta, epsilon, zeta, and eta. Interacts with CD6.
{ECO:0000250|UniProtKB:P07766}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P07766}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P07766}.
-----------------------------------------------------------------------
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EMBL; J02990; AAA40296.1; -; mRNA.
EMBL; M23376; AAA72720.1; -; Genomic_DNA.
EMBL; M23370; AAA72720.1; JOINED; Genomic_DNA.
EMBL; M23371; AAA72720.1; JOINED; Genomic_DNA.
EMBL; M23372; AAA72720.1; JOINED; Genomic_DNA.
EMBL; M23373; AAA72720.1; JOINED; Genomic_DNA.
EMBL; M23374; AAA72720.1; JOINED; Genomic_DNA.
EMBL; M23375; AAA72720.1; JOINED; Genomic_DNA.
CCDS; CCDS23125.1; -.
PIR; A31348; A31348.
RefSeq; NP_031674.1; NM_007648.4.
RefSeq; XP_006510029.1; XM_006509966.3.
UniGene; Mm.210361; -.
PDB; 1JBJ; NMR; -; A=22-100.
PDB; 1XMW; NMR; -; A=22-100.
PDB; 2K4F; NMR; -; A=134-189.
PDB; 3R08; X-ray; 4.10 A; E=22-100.
PDBsum; 1JBJ; -.
PDBsum; 1XMW; -.
PDBsum; 2K4F; -.
PDBsum; 3R08; -.
ProteinModelPortal; P22646; -.
SMR; P22646; -.
BioGrid; 198596; 6.
CORUM; P22646; -.
IntAct; P22646; 3.
MINT; MINT-7895702; -.
STRING; 10090.ENSMUSP00000099896; -.
iPTMnet; P22646; -.
PhosphoSitePlus; P22646; -.
SwissPalm; P22646; -.
EPD; P22646; -.
MaxQB; P22646; -.
PaxDb; P22646; -.
PRIDE; P22646; -.
Ensembl; ENSMUST00000102832; ENSMUSP00000099896; ENSMUSG00000032093.
GeneID; 12501; -.
KEGG; mmu:12501; -.
UCSC; uc009pez.1; mouse.
CTD; 916; -.
MGI; MGI:88332; Cd3e.
eggNOG; ENOG410IYD1; Eukaryota.
eggNOG; ENOG41123JN; LUCA.
GeneTree; ENSGT00510000048592; -.
HOGENOM; HOG000290664; -.
HOVERGEN; HBG102121; -.
InParanoid; P22646; -.
KO; K06451; -.
OMA; QRGQNKE; -.
OrthoDB; EOG091G0PKE; -.
PhylomeDB; P22646; -.
TreeFam; TF335892; -.
Reactome; R-MMU-202424; Downstream TCR signaling.
Reactome; R-MMU-202427; Phosphorylation of CD3 and TCR zeta chains.
Reactome; R-MMU-202430; Translocation of ZAP-70 to Immunological synapse.
Reactome; R-MMU-202433; Generation of second messenger molecules.
Reactome; R-MMU-389948; PD-1 signaling.
EvolutionaryTrace; P22646; -.
PRO; PR:P22646; -.
Proteomes; UP000000589; Chromosome 9.
Bgee; ENSMUSG00000032093; -.
CleanEx; MM_CD3E; -.
ExpressionAtlas; P22646; baseline and differential.
Genevisible; P22646; MM.
GO; GO:0042105; C:alpha-beta T cell receptor complex; IDA:MGI.
GO; GO:0044297; C:cell body; IDA:ARUK-UCL.
GO; GO:0005911; C:cell-cell junction; IDA:MGI.
GO; GO:0043197; C:dendritic spine; IDA:ARUK-UCL.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0001772; C:immunological synapse; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
GO; GO:0042101; C:T cell receptor complex; ISO:MGI.
GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0017124; F:SH3 domain binding; ISO:MGI.
GO; GO:0004871; F:signal transducer activity; IDA:MGI.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0097190; P:apoptotic signaling pathway; IDA:MGI.
GO; GO:0007166; P:cell surface receptor signaling pathway; IDA:MGI.
GO; GO:0021549; P:cerebellum development; IMP:ARUK-UCL.
GO; GO:0016358; P:dendrite development; IMP:ARUK-UCL.
GO; GO:0046649; P:lymphocyte activation; IMP:MGI.
GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IDA:MGI.
GO; GO:0045060; P:negative thymic T cell selection; IDA:MGI.
GO; GO:0046641; P:positive regulation of alpha-beta T cell proliferation; IDA:MGI.
GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IDA:MGI.
GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:MGI.
GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IDA:MGI.
GO; GO:0032753; P:positive regulation of interleukin-4 production; IDA:MGI.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI.
GO; GO:0050870; P:positive regulation of T cell activation; IDA:MGI.
GO; GO:0002669; P:positive regulation of T cell anergy; IDA:MGI.
GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:MGI.
GO; GO:0051260; P:protein homooligomerization; ISO:MGI.
GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
GO; GO:0031295; P:T cell costimulation; IGI:MGI.
GO; GO:0050852; P:T cell receptor signaling pathway; IDA:MGI.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
Pfam; PF02189; ITAM; 1.
SMART; SM00408; IGc2; 1.
SMART; SM00077; ITAM; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS51055; ITAM_1; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome; Disulfide bond;
Immunity; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor;
Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 21
CHAIN 22 189 T-cell surface glycoprotein CD3 epsilon
chain.
/FTId=PRO_0000014609.
TOPO_DOM 23 108 Extracellular. {ECO:0000255}.
TRANSMEM 109 134 Helical. {ECO:0000255}.
TOPO_DOM 135 189 Cytoplasmic. {ECO:0000255}.
DOMAIN 23 99 Ig-like.
DOMAIN 160 187 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOD_RES 170 170 Phosphotyrosine.
{ECO:0000250|UniProtKB:P07766,
ECO:0000255|PROSITE-ProRule:PRU00379}.
MOD_RES 181 181 Phosphotyrosine.
{ECO:0000250|UniProtKB:P07766,
ECO:0000255|PROSITE-ProRule:PRU00379}.
DISULFID 42 83 {ECO:0000244|PDB:1JBJ,
ECO:0000269|PubMed:11439187}.
STRAND 30 34 {ECO:0000244|PDB:1JBJ}.
STRAND 37 41 {ECO:0000244|PDB:1JBJ}.
STRAND 51 54 {ECO:0000244|PDB:1JBJ}.
STRAND 57 59 {ECO:0000244|PDB:1JBJ}.
STRAND 65 71 {ECO:0000244|PDB:1JBJ}.
TURN 74 76 {ECO:0000244|PDB:1JBJ}.
STRAND 79 84 {ECO:0000244|PDB:1JBJ}.
STRAND 94 96 {ECO:0000244|PDB:1JBJ}.
TURN 135 137 {ECO:0000244|PDB:2K4F}.
HELIX 144 146 {ECO:0000244|PDB:2K4F}.
HELIX 168 170 {ECO:0000244|PDB:2K4F}.
HELIX 179 182 {ECO:0000244|PDB:2K4F}.
HELIX 183 185 {ECO:0000244|PDB:2K4F}.
TURN 186 188 {ECO:0000244|PDB:2K4F}.
SEQUENCE 189 AA; 21393 MW; 5CE92F784FA13B96 CRC64;
MRWNTFWGIL CLSLLAVGTC QDDAENIEYK VSISGTSVEL TCPLDSDENL KWEKNGQELP
QKHDKHLVLQ DFSEVEDSGY YVCYTPASNK NTYLYLKARV CEYCVEVDLT AVAIIIIVDI
CITLGLLMVI YYWSKNRKAK AKPVTRGTGA GSRPRGQNKE RPPPVPNPDY EPIRKGQRDL
YSGLNQRAV


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