Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)

 CD3G_BOVIN              Reviewed;         173 AA.
Q28074; Q3SZA7;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
30-MAY-2006, sequence version 2.
25-OCT-2017, entry version 105.
RecName: Full=T-cell surface glycoprotein CD3 gamma chain;
AltName: Full=T-cell receptor T3 gamma chain;
AltName: CD_antigen=CD3g;
Flags: Precursor;
Name=CD3G;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-91.
PubMed=1971793; DOI=10.1002/eji.1830200415;
Clevers H., Machugh N.D., Bensaid A., Dunlap S., Baldwin C.L.,
Kaushal A., Iams K., Howard C.J., Morrison W.I.;
"Identification of a bovine surface antigen uniquely expressed on CD4-
CD8-T cell receptor gamma/delta+ T lymphocytes.";
Eur. J. Immunol. 20:809-817(1990).
-!- FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell
surface that plays an essential role in adaptive immune response.
When antigen presenting cells (APCs) activate T-cell receptor
(TCR), TCR-mediated signals are transmitted across the cell
membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3
chains contain immunoreceptor tyrosine-based activation motifs
(ITAMs) in their cytoplasmic domain. Upon TCR engagement, these
motifs become phosphorylated by Src family protein tyrosine
kinases LCK and FYN, resulting in the activation of downstream
signaling pathways. In addition to this role of signal
transduction in T-cell activation, CD3G plays an essential role in
the dynamic regulation of TCR expression at the cell surface.
Indeed, constitutive TCR cycling is dependent on the di-leucine-
based (diL) receptor-sorting motif present in CD3G.
{ECO:0000250|UniProtKB:P09693}.
-!- SUBUNIT: The TCR-CD3 complex is composed of a CD3D/CD3E and a
CD3G/CD3E heterodimers that preferentially associate with TCRalpha
and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and
TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with
CD3Z homodimer to form the TCR-CD3 complex. Alternatively,
TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
{ECO:0000250|UniProtKB:P09693}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P09693}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P09693}.
-!- DOMAIN: A di-leucine motif and a tyrosine-based motif are
individually sufficient to induce both endocytosis and delivery to
lysosomes. {ECO:0000250|UniProtKB:P09693}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8. Phosphorylated also
by PKC; leading to the TCR complex down-regulation.
{ECO:0000250|UniProtKB:P09693}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8.
{ECO:0000250|UniProtKB:P04234}.
-!- SEQUENCE CAUTION:
Sequence=CAA37366.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; BC103010; AAI03011.1; -; mRNA.
EMBL; X53268; CAA37366.1; ALT_INIT; mRNA.
PIR; A60232; A60232.
UniGene; Bt.13934; -.
ProteinModelPortal; Q28074; -.
SMR; Q28074; -.
STRING; 9913.ENSBTAP00000044200; -.
PaxDb; Q28074; -.
PRIDE; Q28074; -.
eggNOG; ENOG410IWAX; Eukaryota.
eggNOG; ENOG410Y2TD; LUCA.
HOGENOM; HOG000015287; -.
HOVERGEN; HBG005278; -.
InParanoid; Q28074; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR032052; Ig_4.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
Pfam; PF16680; Ig_4; 1.
Pfam; PF02189; ITAM; 1.
SMART; SM00408; IGc2; 1.
SMART; SM00077; ITAM; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS51055; ITAM_1; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunity; Immunoglobulin domain; Membrane;
Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 22 {ECO:0000250}.
CHAIN 23 173 T-cell surface glycoprotein CD3 gamma
chain.
/FTId=PRO_0000014614.
TOPO_DOM 23 111 Extracellular. {ECO:0000255}.
TRANSMEM 112 132 Helical. {ECO:0000255}.
TOPO_DOM 133 173 Cytoplasmic. {ECO:0000255}.
DOMAIN 24 94 Ig-like.
DOMAIN 145 173 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOTIF 149 150 Di-leucine motif.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 141 141 Phosphoserine.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 144 144 Phosphoserine.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 144 144 Phosphoserine; by PKC.
{ECO:0000250|UniProtKB:P09693}.
CARBOHYD 45 45 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 88 88 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 42 83 {ECO:0000250|UniProtKB:P09693}.
SEQUENCE 173 AA; 19463 MW; 74ADF52B384AA06C CRC64;
MEQGKHLAGL ILAVFLLQGT MAHVKEVKVD DNREDGSVIL ICVTNDTTIT WLKDVEQIGS
GDTKKNTWNL GSSTKDPRGI YKCEGSNNQS KSLQIYYRMC QNCIELNPST VAGFIFTEIV
SIFLLAVGVY FIAGQEGVRQ SRASDKQTLL NNDQLYQPLK EREDDQYSHL RKN


Related products :

Catalog number Product name Quantity
EIAAB06337 CD3G,Homo sapiens,Human,T3G,T-cell receptor T3 gamma chain,T-cell surface glycoprotein CD3 gamma chain
EIAAB06338 Cd3g,Mouse,Mus musculus,T-cell receptor T3 gamma chain,T-cell surface glycoprotein CD3 gamma chain
EIAAB06334 Bos taurus,Bovine,CD3G,T-cell receptor T3 gamma chain,T-cell surface glycoprotein CD3 gamma chain
EIAAB06336 Cd3g,Rat,Rattus norvegicus,T-cell receptor T3 gamma chain,T-cell surface glycoprotein CD3 gamma chain
EIAAB06335 CD3G,Pig,Sus scrofa,T-cell receptor T3 gamma chain,T-cell surface glycoprotein CD3 gamma chain
CSB-EL004933RA Rat T-cell surface glycoprotein CD3 gamma chain(CD3G) ELISA kit 96T
H4337 T-cell surface glycoprotein CD3 gamma chain (CD3G), Rat, ELISA Kit 96T
H4336 T-cell surface glycoprotein CD3 gamma chain (CD3G), Pig, ELISA Kit 96T
H4333 T-cell surface glycoprotein CD3 gamma chain (CD3G), Bovine, ELISA Kit 96T
CSB-EL004933RA Rat T-cell surface glycoprotein CD3 gamma chain(CD3G) ELISA kit SpeciesRat 96T
H4334 T-cell surface glycoprotein CD3 gamma chain (CD3G), Human, ELISA Kit 96T
H4335 T-cell surface glycoprotein CD3 gamma chain (CD3G), Mouse, ELISA Kit 96T
CSB-EL004933PI Pig T-cell surface glycoprotein CD3 gamma chain(CD3G) ELISA kit SpeciesPig 96T
CSB-EL004933MO Mouse T-cell surface glycoprotein CD3 gamma chain(CD3G) ELISA kit 96T
CSB-EL004933HU Human T-cell surface glycoprotein CD3 gamma chain(CD3G) ELISA kit 96T
CSB-EL004933BO Bovine T-cell surface glycoprotein CD3 gamma chain(CD3G) ELISA kit 96T
H4338 T-cell surface glycoprotein CD3 gamma chain (CD3G), Sheep, ELISA Kit 96T
CSB-EL004933MO Mouse T-cell surface glycoprotein CD3 gamma chain(CD3G) ELISA kit SpeciesMouse 96T
CSB-EL004933BO Bovine T-cell surface glycoprotein CD3 gamma chain(CD3G) ELISA kit SpeciesBovine 96T
CSB-EL004933SH Sheep T-cell surface glycoprotein CD3 gamma chain(CD3G) ELISA kit SpeciesSheep 96T
CD3G_RAT ELISA Kit FOR T-cell surface glycoprotein CD3 gamma chain; organism: Rat; gene name: Cd3g 96T
CSB-EL004933HU Human T-cell surface glycoprotein CD3 gamma chain(CD3G) ELISA kit SpeciesHuman 96T
CD3G_MOUSE ELISA Kit FOR T-cell surface glycoprotein CD3 gamma chain; organism: Mouse; gene name: Cd3g 96T
EIAAB06400 Cd8b,Cd8b1,Ly-3,Lymphocyte antigen 3,Lyt3,Lyt-3,Mouse,Mus musculus,T-cell membrane glycoprotein Ly-3,T-cell surface glycoprotein CD8 beta chain,T-cell surface glycoprotein Lyt-3
EIAAB43835 Homo sapiens,Human,T-cell receptor gamma chain C region PT-gamma-1_2,T-cell receptor gamma-2 chain C region,TCRGC2,TRGC2


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur