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T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
CD3G_PIG Reviewed; 182 AA.
Q5PXD3;
30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
04-JAN-2005, sequence version 1.
28-FEB-2018, entry version 87.
RecName: Full=T-cell surface glycoprotein CD3 gamma chain;
AltName: Full=T-cell receptor T3 gamma chain;
AltName: CD_antigen=CD3g;
Flags: Precursor;
Name=CD3G;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Yang H., Wileman T.;
"Structural differences between the CD3 molecules expressed at the
surface of alpha beta- and gamma delta-T cells revealed by monoclonal
antibodies.";
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell
surface that plays an essential role in adaptive immune response.
When antigen presenting cells (APCs) activate T-cell receptor
(TCR), TCR-mediated signals are transmitted across the cell
membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3
chains contain immunoreceptor tyrosine-based activation motifs
(ITAMs) in their cytoplasmic domain. Upon TCR engagement, these
motifs become phosphorylated by Src family protein tyrosine
kinases LCK and FYN, resulting in the activation of downstream
signaling pathways. In addition to this role of signal
transduction in T-cell activation, CD3G plays an essential role in
the dynamic regulation of TCR expression at the cell surface.
Indeed, constitutive TCR cycling is dependent on the di-leucine-
based (diL) receptor-sorting motif present in CD3G.
{ECO:0000250|UniProtKB:P09693}.
-!- SUBUNIT: The TCR-CD3 complex is composed of a CD3D/CD3E and a
CD3G/CD3E heterodimers that preferentially associate with TCRalpha
and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and
TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with
CD3Z homodimer to form the TCR-CD3 complex. Alternatively,
TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
{ECO:0000250|UniProtKB:P09693}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P09693}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P09693}.
-!- DOMAIN: A di-leucine motif and a tyrosine-based motif are
individually sufficient to induce both endocytosis and delivery to
lysosomes. {ECO:0000250|UniProtKB:P09693}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8. Phosphorylated also
by PKC; leading to the TCR complex down-regulation.
{ECO:0000250|UniProtKB:P09693}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8.
{ECO:0000250|UniProtKB:P04234}.
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EMBL; AY823638; AAV80704.1; -; mRNA.
RefSeq; NP_001008686.1; NM_001008686.1.
RefSeq; XP_005653762.1; XM_005653705.2.
RefSeq; XP_005653763.1; XM_005653706.2.
RefSeq; XP_005653764.1; XM_005653707.2.
UniGene; Ssc.30285; -.
ProteinModelPortal; Q5PXD3; -.
SMR; Q5PXD3; -.
STRING; 9823.ENSSSCP00000016017; -.
PaxDb; Q5PXD3; -.
PRIDE; Q5PXD3; -.
Ensembl; ENSSSCT00000016460; ENSSSCP00000016017; ENSSSCG00000015094.
Ensembl; ENSSSCT00000056128; ENSSSCP00000043282; ENSSSCG00000015094.
GeneID; 494013; -.
KEGG; ssc:494013; -.
CTD; 917; -.
eggNOG; ENOG410IWAX; Eukaryota.
eggNOG; ENOG410Y2TD; LUCA.
GeneTree; ENSGT00510000046930; -.
HOGENOM; HOG000015287; -.
HOVERGEN; HBG005278; -.
InParanoid; Q5PXD3; -.
KO; K06452; -.
OMA; DRENDQY; -.
OrthoDB; EOG091G0MXQ; -.
TreeFam; TF335892; -.
Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Reactome; R-SSC-202424; Downstream TCR signaling.
Reactome; R-SSC-202427; Phosphorylation of CD3 and TCR zeta chains.
Reactome; R-SSC-202430; Translocation of ZAP-70 to Immunological synapse.
Reactome; R-SSC-202433; Generation of second messenger molecules.
Reactome; R-SSC-2029481; FCGR activation.
Reactome; R-SSC-2029482; Regulation of actin dynamics for phagocytic cup formation.
Reactome; R-SSC-2029485; Role of phospholipids in phagocytosis.
Reactome; R-SSC-389948; PD-1 signaling.
Reactome; R-SSC-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-SSC-8856828; Clathrin-mediated endocytosis.
Proteomes; UP000008227; Chromosome 9.
Bgee; ENSSSCG00000015094; -.
Genevisible; Q5PXD3; SS.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR032052; Ig_4.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
Pfam; PF16680; Ig_4; 1.
Pfam; PF02189; ITAM; 1.
SMART; SM00408; IGc2; 1.
SMART; SM00077; ITAM; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS51055; ITAM_1; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunity; Immunoglobulin domain; Membrane;
Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 182 T-cell surface glycoprotein CD3 gamma
chain.
/FTId=PRO_0000238449.
TOPO_DOM 23 116 Extracellular. {ECO:0000255}.
TRANSMEM 117 137 Helical. {ECO:0000255}.
TOPO_DOM 138 182 Cytoplasmic. {ECO:0000255}.
DOMAIN 23 98 Ig-like.
DOMAIN 149 177 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOTIF 153 154 Di-leucine motif.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 145 145 Phosphoserine.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 148 148 Phosphoserine; by PKC.
{ECO:0000250|UniProtKB:P09693}.
CARBOHYD 66 66 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 46 87 {ECO:0000250|UniProtKB:P09693}.
SEQUENCE 182 AA; 20461 MW; 037F78AA546F3EA1 CRC64;
MEQGKHLAGL ILAITLLQGT MAQLKEGKHS VLLDDNREDG SVLLTCGLPD QNIRWFKDGK
EICSLNNSRS TCNLGSSSKD PRGIYWCEGS KENSKRLQVY YRMCQNCIEL NSATVSGFIF
TEIISLFFLA VGVYFIAGQD GVRQSRASDK QTLLSNDQLY QPLKDREDDQ YSHLQGNNSR
KN
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Pathways :
WP1011: T Cell Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1654: gamma-Hexachlorocyclohexane degradation
WP2006: Squamous cell TarBase
WP2152: BDNF
WP2328: Allograft rejection
WP352: T Cell Receptor Signaling Pathway
WP480: T Cell Receptor Signaling Pathway
WP542: Electron Transport Chain
WP780: T Cell Receptor Signaling Pathway
WP894: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1794: Cell surface interactions at the vascular wall
WP1833: Integrin cell surface interactions
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP2292: Chemokine signaling pathway
WP23: B Cell Receptor Signaling Pathway
WP274: B Cell Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP794: B Cell Receptor Signaling Pathway
WP908: B Cell Receptor Signaling Pathway
WP1002: Electron Transport Chain
Related Genes :
[gag-pro-pol] Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol) [Cleaved into: Matrix protein p19 (MA); Capsid protein p24 (CA); Nucleocapsid protein p15-pro (NC') (NC-pro); Protease (PR) (EC 3.4.23.-); p1; Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[Art2b Rt6-b] T-cell ecto-ADP-ribosyltransferase 2 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 2) (ARTC2) (Alloantigen Rt6.2) (Mono(ADP-ribosyl)transferase 2B) (NAD(+) glycohydrolase) (EC 3.2.2.5) (T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2) (T-cell mono(ADP-ribosyl)transferase 2) (T-cell surface protein Rt6.2)
[Art2a Art2a-ps Rt6-1 Rt6.1] T-cell ecto-ADP-ribosyltransferase 1 (EC 2.4.2.31) (ADP-ribosyltransferase 2a pseudogene) (ADP-ribosyltransferase C2 and C3 toxin-like 2) (ARTC2) (Mono(ADP-ribosyl)transferase 2A) (NAD(+) glycohydrolase) (EC 3.2.2.5) (T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1) (T-cell differentiation marker Rt6 homolog 1) (T-cell mono(ADP-ribosyl)transferase 1)
[Art2b Rt6-2 Rt6.2] T-cell ecto-ADP-ribosyltransferase 2 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 2) (ARTC2) (Mono(ADP-ribosyl)transferase 2B) (NAD(+) glycohydrolase) (EC 3.2.2.5) (T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2) (T-cell differentiation marker Rt6 homolog 2) (T-cell mono(ADP-ribosyl)transferase 2)
[Cd4] T-cell surface glycoprotein CD4 (T-cell differentiation antigen L3T4) (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[Art2a Rt6 Rt6-a] T-cell ecto-ADP-ribosyltransferase 1 (EC 2.4.2.31) (Alloantigen Rt6.1) (Mono(ADP-ribosyl)transferase 2A) (NAD(+) glycohydrolase) (EC 3.2.2.5) (T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1) (T-cell mono(ADP-ribosyl)transferase 1) (T-cell surface protein Rt6.1)
[HAVCR2 TIM3 TIMD3] Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3)
[ITK EMT LYK] Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3)
[I79_000002] Trans-acting T-cell-specific transcription factor GATA-3
[Cd8b Cd8b1 Ly-3 Lyt-3 Lyt3] T-cell surface glycoprotein CD8 beta chain (Lymphocyte antigen 3) (T-cell membrane glycoprotein Ly-3) (T-cell surface glycoprotein Lyt-3) (CD antigen CD8b)
[CD7] T-cell antigen CD7 (GP40) (T-cell leukemia antigen) (T-cell surface antigen Leu-9) (TP41) (CD antigen CD7)
[CD3E T3E] T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
[CD247 CD3Z T3Z TCRZ] T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)
[CD3D T3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[Havcr1 Kim1 Tim1 Timd1] Hepatitis A virus cellular receptor 1 homolog (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (T-cell immunoglobulin mucin receptor 1) (TIM-1)
[CD3G T3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[tax] Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of HTLV-1)
[gag-pro-pol] Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol) [Cleaved into: Matrix protein p19 (MA); Capsid protein p24 (CA); Nucleocapsid protein p15-pro (NC') (NC-pro); Protease (PR) (EC 3.4.23.-); p1; Reverse transcriptase/ribonuclease H, p49 subunit (p49 RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Reverse transcriptase/ribonuclease H, p62 subunit (p62 RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[Cd3d T3d] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[env] Envelope glycoprotein gp62 (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 46) (gp46); Transmembrane protein (TM) (Glycoprotein 21) (gp21)]
[HAVCR1 KIM1 TIM1 TIMD1] Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM) (TIM-1) (T-cell membrane protein 1)
[gag] Gag polyprotein (Pr53Gag) [Cleaved into: Matrix protein p19 (MA); Capsid protein p24 (CA); Nucleocapsid protein p15-gag (NC-gag)]
[gag-pro prt] Gag-Pro polyprotein (Pr76Gag-Pro) [Cleaved into: Matrix protein p19 (MA); Capsid protein p24 (CA); Nucleocapsid protein p15-pro (NC') (NC-pro); Protease (PR) (EC 3.4.23.-); p1; Transframe peptide (TFP) (p8)]
[tax] Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of HTLV-1)
[gag-pro-pol] Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol) [Cleaved into: Matrix protein p19 (MA); Capsid protein p24 (CA); Nucleocapsid protein p15-pro (NC') (NC-pro); Protease (PR) (EC 3.4.23.-); p1; Reverse transcriptase/ribonuclease H, p49 subunit (p49 RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Reverse transcriptase/ribonuclease H, p62 subunit (p62 RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[CD4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[TAL1 BHLHA17 SCL TCL5] T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)
[Cd3e] T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
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