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 CD3G_PIG                Reviewed;         182 AA.
 Q5PXD3;
 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
 04-JAN-2005, sequence version 1.
 12-SEP-2018, entry version 89.
 RecName: Full=T-cell surface glycoprotein CD3 gamma chain;
 AltName: Full=T-cell receptor T3 gamma chain;
 AltName: CD_antigen=CD3g;
 Flags: Precursor;
 Name=CD3G;
 Sus scrofa (Pig).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
 Sus.
 NCBI_TaxID=9823;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA].
 Yang H., Wileman T.;
 "Structural differences between the CD3 molecules expressed at the
 surface of alpha beta- and gamma delta-T cells revealed by monoclonal
 antibodies.";
 Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
 -!- FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell
     surface that plays an essential role in adaptive immune response.
     When antigen presenting cells (APCs) activate T-cell receptor
     (TCR), TCR-mediated signals are transmitted across the cell
     membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3
     chains contain immunoreceptor tyrosine-based activation motifs
     (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these
     motifs become phosphorylated by Src family protein tyrosine
     kinases LCK and FYN, resulting in the activation of downstream
     signaling pathways. In addition to this role of signal
     transduction in T-cell activation, CD3G plays an essential role in
     the dynamic regulation of TCR expression at the cell surface.
     Indeed, constitutive TCR cycling is dependent on the di-leucine-
     based (diL) receptor-sorting motif present in CD3G.
     {ECO:0000250|UniProtKB:P09693}.
 -!- SUBUNIT: The TCR-CD3 complex is composed of a CD3D/CD3E and a
     CD3G/CD3E heterodimers that preferentially associate with TCRalpha
     and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and
     TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with
     CD3Z homodimer to form the TCR-CD3 complex. Alternatively,
     TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
     {ECO:0000250|UniProtKB:P09693}.
 -!- SUBCELLULAR LOCATION: Cell membrane
     {ECO:0000250|UniProtKB:P09693}; Single-pass type I membrane
     protein {ECO:0000250|UniProtKB:P09693}.
 -!- DOMAIN: A di-leucine motif and a tyrosine-based motif are
     individually sufficient to induce both endocytosis and delivery to
     lysosomes. {ECO:0000250|UniProtKB:P09693}.
 -!- PTM: Phosphorylated on Tyr residues after T-cell receptor
     triggering by LCK in association with CD4/CD8. Phosphorylated also
     by PKC; leading to the TCR complex down-regulation.
     {ECO:0000250|UniProtKB:P09693}.
 -!- PTM: Phosphorylated on Tyr residues after T-cell receptor
     triggering by LCK in association with CD4/CD8.
     {ECO:0000250|UniProtKB:P04234}.
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 EMBL; AY823638; AAV80704.1; -; mRNA.
 RefSeq; NP_001008686.1; NM_001008686.1.
 RefSeq; XP_005653762.1; XM_005653705.2.
 RefSeq; XP_005653763.1; XM_005653706.2.
 RefSeq; XP_005653764.1; XM_005653707.2.
 UniGene; Ssc.30285; -.
 ProteinModelPortal; Q5PXD3; -.
 SMR; Q5PXD3; -.
 STRING; 9823.ENSSSCP00000016017; -.
 PaxDb; Q5PXD3; -.
 PRIDE; Q5PXD3; -.
 Ensembl; ENSSSCT00000016460; ENSSSCP00000016017; ENSSSCG00000015094.
 Ensembl; ENSSSCT00000056128; ENSSSCP00000043282; ENSSSCG00000015094.
 GeneID; 494013; -.
 KEGG; ssc:494013; -.
 CTD; 917; -.
 eggNOG; ENOG410IWAX; Eukaryota.
 eggNOG; ENOG410Y2TD; LUCA.
 GeneTree; ENSGT00510000046930; -.
 HOGENOM; HOG000015287; -.
 HOVERGEN; HBG005278; -.
 InParanoid; Q5PXD3; -.
 KO; K06452; -.
 OMA; DRENDQY; -.
 OrthoDB; EOG091G0MXQ; -.
 TreeFam; TF335892; -.
 Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
 Reactome; R-SSC-202424; Downstream TCR signaling.
 Reactome; R-SSC-202427; Phosphorylation of CD3 and TCR zeta chains.
 Reactome; R-SSC-202430; Translocation of ZAP-70 to Immunological synapse.
 Reactome; R-SSC-202433; Generation of second messenger molecules.
 Reactome; R-SSC-2029481; FCGR activation.
 Reactome; R-SSC-2029482; Regulation of actin dynamics for phagocytic cup formation.
 Reactome; R-SSC-2029485; Role of phospholipids in phagocytosis.
 Reactome; R-SSC-389948; PD-1 signaling.
 Reactome; R-SSC-8856825; Cargo recognition for clathrin-mediated endocytosis.
 Reactome; R-SSC-8856828; Clathrin-mediated endocytosis.
 Proteomes; UP000008227; Chromosome 9.
 Bgee; ENSSSCG00000015094; Expressed in 5 organ(s), highest expression level in lung.
 Genevisible; Q5PXD3; SS.
 GO; GO:0042105; C:alpha-beta T cell receptor complex; IEA:Ensembl.
 GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
 GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
 GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
 GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
 GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
 GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
 GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:Ensembl.
 GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
 GO; GO:0015031; P:protein transport; IEA:Ensembl.
 GO; GO:0070228; P:regulation of lymphocyte apoptotic process; IEA:Ensembl.
 Gene3D; 2.60.40.10; -; 1.
 InterPro; IPR015484; CD3_esu/gsu/dsu.
 InterPro; IPR036179; Ig-like_dom_sf.
 InterPro; IPR013783; Ig-like_fold.
 InterPro; IPR032052; Ig_4.
 InterPro; IPR003598; Ig_sub2.
 InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
 PANTHER; PTHR10570; PTHR10570; 1.
 Pfam; PF16680; Ig_4; 1.
 Pfam; PF02189; ITAM; 1.
 SMART; SM00408; IGc2; 1.
 SMART; SM00077; ITAM; 1.
 SUPFAM; SSF48726; SSF48726; 1.
 PROSITE; PS51055; ITAM_1; 1.
 2: Evidence at transcript level;
 Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
 Glycoprotein; Immunity; Immunoglobulin domain; Membrane;
 Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane;
 Transmembrane helix.
 SIGNAL        1     22       {ECO:0000255}.
 CHAIN        23    182       T-cell surface glycoprotein CD3 gamma
                              chain.
                              /FTId=PRO_0000238449.
 TOPO_DOM     23    116       Extracellular. {ECO:0000255}.
 TRANSMEM    117    137       Helical. {ECO:0000255}.
 TOPO_DOM    138    182       Cytoplasmic. {ECO:0000255}.
 DOMAIN       23     98       Ig-like.
 DOMAIN      149    177       ITAM. {ECO:0000255|PROSITE-
                              ProRule:PRU00379}.
 MOTIF       153    154       Di-leucine motif.
                              {ECO:0000250|UniProtKB:P09693}.
 MOD_RES     145    145       Phosphoserine.
                              {ECO:0000250|UniProtKB:P09693}.
 MOD_RES     148    148       Phosphoserine; by PKC.
                              {ECO:0000250|UniProtKB:P09693}.
 CARBOHYD     66     66       N-linked (GlcNAc...) asparagine.
                              {ECO:0000255}.
 DISULFID     46     87       {ECO:0000250|UniProtKB:P09693}.
 SEQUENCE   182 AA;  20461 MW;  037F78AA546F3EA1 CRC64;
 MEQGKHLAGL ILAITLLQGT MAQLKEGKHS VLLDDNREDG SVLLTCGLPD QNIRWFKDGK
 EICSLNNSRS TCNLGSSSKD PRGIYWCEGS KENSKRLQVY YRMCQNCIEL NSATVSGFIF
 TEIISLFFLA VGVYFIAGQD GVRQSRASDK QTLLSNDQLY QPLKDREDDQ YSHLQGNNSR
 KN

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