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T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)

 CD3G_MACFA              Reviewed;         181 AA.
Q95LI7;
23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
22-NOV-2017, entry version 79.
RecName: Full=T-cell surface glycoprotein CD3 gamma chain;
AltName: Full=T-cell receptor T3 gamma chain;
AltName: CD_antigen=CD3g;
Flags: Precursor;
Name=CD3G;
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11515669;
Uda A., Tanabayashi K., Mukai R., Yachi M., Nam K., Yamada A.;
"CD3 polymorphism in cynomolgus monkeys (Macaca fascicularis).";
J. Med. Primatol. 30:141-147(2001).
-!- FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell
surface that plays an essential role in adaptive immune response.
When antigen presenting cells (APCs) activate T-cell receptor
(TCR), TCR-mediated signals are transmitted across the cell
membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3
chains contain immunoreceptor tyrosine-based activation motifs
(ITAMs) in their cytoplasmic domain. Upon TCR engagement, these
motifs become phosphorylated by Src family protein tyrosine
kinases LCK and FYN, resulting in the activation of downstream
signaling pathways. In addition to this role of signal
transduction in T-cell activation, CD3G plays an essential role in
the dynamic regulation of TCR expression at the cell surface.
Indeed, constitutive TCR cycling is dependent on the di-leucine-
based (diL) receptor-sorting motif present in CD3G.
{ECO:0000250|UniProtKB:P09693}.
-!- SUBUNIT: The TCR-CD3 complex is composed of a CD3D/CD3E and a
CD3G/CD3E heterodimers that preferentially associate with TCRalpha
and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and
TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with
CD3Z homodimer to form the TCR-CD3 complex. Alternatively,
TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
{ECO:0000250|UniProtKB:P09693}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P09693}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P09693}.
-!- DOMAIN: A di-leucine motif and a tyrosine-based motif are
individually sufficient to induce both endocytosis and delivery to
lysosomes. {ECO:0000250|UniProtKB:P09693}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8. Phosphorylated also
by PKC; leading to the TCR complex down-regulation.
{ECO:0000250|UniProtKB:P09693}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8.
{ECO:0000250|UniProtKB:P04234}.
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EMBL; AB073992; BAB71848.1; -; mRNA.
RefSeq; NP_001270839.1; NM_001283910.1.
UniGene; Mfa.6116; -.
ProteinModelPortal; Q95LI7; -.
SMR; Q95LI7; -.
GeneID; 102134381; -.
KEGG; mcf:102134381; -.
CTD; 917; -.
HOVERGEN; HBG005278; -.
KO; K06452; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
GO; GO:0004888; F:transmembrane signaling receptor activity; ISS:UniProtKB.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0007166; P:cell surface receptor signaling pathway; ISS:UniProtKB.
GO; GO:0007163; P:establishment or maintenance of cell polarity; ISS:UniProtKB.
GO; GO:0015031; P:protein transport; ISS:UniProtKB.
GO; GO:0070228; P:regulation of lymphocyte apoptotic process; ISS:UniProtKB.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR032052; Ig_4.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
Pfam; PF16680; Ig_4; 1.
Pfam; PF02189; ITAM; 1.
SMART; SM00408; IGc2; 1.
SMART; SM00077; ITAM; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS51055; ITAM_1; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Disulfide bond; Glycoprotein;
Immunity; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor;
Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 22 {ECO:0000250}.
CHAIN 23 181 T-cell surface glycoprotein CD3 gamma
chain.
/FTId=PRO_0000014616.
TOPO_DOM 23 113 Extracellular. {ECO:0000255}.
TRANSMEM 114 134 Helical. {ECO:0000255}.
TOPO_DOM 135 181 Cytoplasmic. {ECO:0000255}.
DOMAIN 24 97 Ig-like.
DOMAIN 148 176 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOTIF 152 153 Di-leucine motif.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 144 144 Phosphoserine.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 147 147 Phosphoserine.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 147 147 Phosphoserine; by PKC.
{ECO:0000250|UniProtKB:P09693}.
CARBOHYD 51 51 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 45 86 {ECO:0000250|UniProtKB:P09693}.
SEQUENCE 181 AA; 20530 MW; 1F8EA17D2446E5B9 CRC64;
MVQGKGLTGF ILAIILLQGS LAQSFEENRK LNVYNQEDGS VLLTCHVKNT NITWFKEGKM
IDILTAHKNK WNLGSNTKDP RGVYQCKGSK DKSKTLQVYY RMCQNCIELN AATILGFVFA
EIISIFFLAV GVYFIAGQDG VRQSRASDKQ TLLPNDQLYQ PLKDREDDQY SHLQGNQLRM
N


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