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T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g) (Fragment)

 CD3G_SHEEP              Reviewed;         147 AA.
P18439;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 1.
25-OCT-2017, entry version 98.
RecName: Full=T-cell surface glycoprotein CD3 gamma chain;
AltName: Full=T-cell receptor T3 gamma chain;
AltName: CD_antigen=CD3g;
Flags: Fragment;
Name=CD3G;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymphocyte;
PubMed=2143727; DOI=10.1002/eji.1830200715;
Hein W.R., Tunnacliffe A.;
"Characterization of the CD3 gamma and delta invariant subunits of the
sheep T cell antigen receptor.";
Eur. J. Immunol. 20:1505-1511(1990).
-!- FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell
surface that plays an essential role in adaptive immune response.
When antigen presenting cells (APCs) activate T-cell receptor
(TCR), TCR-mediated signals are transmitted across the cell
membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3
chains contain immunoreceptor tyrosine-based activation motifs
(ITAMs) in their cytoplasmic domain. Upon TCR engagement, these
motifs become phosphorylated by Src family protein tyrosine
kinases LCK and FYN, resulting in the activation of downstream
signaling pathways. In addition to this role of signal
transduction in T-cell activation, CD3G plays an essential role in
the dynamic regulation of TCR expression at the cell surface.
Indeed, constitutive TCR cycling is dependent on the di-leucine-
based (diL) receptor-sorting motif present in CD3G.
{ECO:0000250|UniProtKB:P09693}.
-!- SUBUNIT: The TCR-CD3 complex is composed of a CD3D/CD3E and a
CD3G/CD3E heterodimers that preferentially associate with TCRalpha
and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and
TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with
CD3Z homodimer to form the TCR-CD3 complex. Alternatively,
TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
{ECO:0000250|UniProtKB:P09693}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P09693}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P09693}.
-!- DOMAIN: A di-leucine motif and a tyrosine-based motif are
individually sufficient to induce both endocytosis and delivery to
lysosomes. {ECO:0000250|UniProtKB:P09693}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8. Phosphorylated also
by PKC; leading to the TCR complex down-regulation.
{ECO:0000250|UniProtKB:P09693}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8.
{ECO:0000250|UniProtKB:P04234}.
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EMBL; X52994; CAA37183.1; -; mRNA.
PIR; A43547; A43547.
UniGene; Oar.428; -.
ProteinModelPortal; P18439; -.
SMR; P18439; -.
PRIDE; P18439; -.
HOVERGEN; HBG005278; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
GO; GO:0004888; F:transmembrane signaling receptor activity; ISS:UniProtKB.
GO; GO:0007166; P:cell surface receptor signaling pathway; ISS:UniProtKB.
GO; GO:0007163; P:establishment or maintenance of cell polarity; ISS:UniProtKB.
GO; GO:0015031; P:protein transport; ISS:UniProtKB.
GO; GO:0070228; P:regulation of lymphocyte apoptotic process; ISS:UniProtKB.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR032052; Ig_4.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
Pfam; PF16680; Ig_4; 1.
Pfam; PF02189; ITAM; 1.
SMART; SM00408; IGc2; 1.
SMART; SM00077; ITAM; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS51055; ITAM_1; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunity; Immunoglobulin domain; Membrane;
Phosphoprotein; Receptor; Reference proteome; Transmembrane;
Transmembrane helix.
CHAIN <1 147 T-cell surface glycoprotein CD3 gamma
chain.
/FTId=PRO_0000072672.
TOPO_DOM <1 85 Extracellular. {ECO:0000255}.
TRANSMEM 86 106 Helical. {ECO:0000255}.
TOPO_DOM 107 147 Cytoplasmic. {ECO:0000255}.
DOMAIN 7 64 Ig-like.
DOMAIN 119 147 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOTIF 123 124 Di-leucine motif.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 115 115 Phosphoserine.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 118 118 Phosphoserine.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 118 118 Phosphoserine; by PKC.
{ECO:0000250|UniProtKB:P09693}.
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 16 57 {ECO:0000250|UniProtKB:P09693}.
NON_TER 1 1
SEQUENCE 147 AA; 16723 MW; 116B33773033D6B8 CRC64;
VKVDDNQEDG SVILICVTDE KKITWLKDMK EISSGDTNKL TWDLGSSTKD PRGIYECKGS
SNESKSLQIY YRMCQNCIEL NLATVAGFIF TEIVSIFLLA VGVYFIAGQE GVRQSRASDK
QTLLNNDQLY QPLKEREDDQ YSHLRKK


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