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T-cell surface glycoprotein CD8 alpha chain (CD antigen CD8a)

 CD8A_FELCA              Reviewed;         239 AA.
P41688;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
25-OCT-2017, entry version 108.
RecName: Full=T-cell surface glycoprotein CD8 alpha chain;
AltName: CD_antigen=CD8a;
Flags: Precursor;
Name=CD8A;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Thymus;
PubMed=8132208;
Pecoraro M., Kawaguchi Y., Miyazawa T., Norimine J., Maeda K.,
Toyosaki T., Tohya Y., Kai C., Mikami T.;
"Isolation, sequence and expression of a cDNA encoding the alpha-chain
of the feline CD8.";
Immunology 81:127-131(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Thymus;
Miyazawa T.;
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Integral membrane glycoprotein that plays an essential
role in the immune response and serves multiple functions in
responses against both external and internal offenses. In T-cells,
functions primarily as a coreceptor for MHC class I
molecule:peptide complex. The antigens presented by class I
peptides are derived from cytosolic proteins while class II
derived from extracellular proteins. Interacts simultaneously with
the T-cell receptor (TCR) and the MHC class I proteins presented
by antigen presenting cells (APCs). In turn, recruits the Src
kinase LCK to the vicinity of the TCR-CD3 complex. LCK then
initiates different intracellular signaling pathways by
phosphorylating various substrates ultimately leading to
lymphokine production, motility, adhesion and activation of
cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to
recognize and eliminate infected cells and tumor cells. In NK-
cells, the presence of CD8A homodimers at the cell surface
provides a survival mechanism allowing conjugation and lysis of
multiple target cells. CD8A homodimer molecules also promote the
survival and differentiation of activated lymphocytes into memory
CD8 T-cells. {ECO:0000250|UniProtKB:P01732}.
-!- SUBUNIT: Forms disulfide-linked heterodimers with CD8B at the cell
surface. Forms also homodimers in several cell types including NK-
cells or peripheral blood T-lymphocytes. Interacts with the MHC
class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent
manner. {ECO:0000250|UniProtKB:P01732}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P01732}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P01732}. Note=CD8A localizes to
lipid rafts only when associated with its partner CD8B.
{ECO:0000250|UniProtKB:P01732}.
-!- PTM: Palmitoylated, but association with CD8B seems to be more
important for the enrichment of CD8A in lipid rafts.
{ECO:0000250|UniProtKB:P01732}.
-!- PTM: O-glycosylated. {ECO:0000250|UniProtKB:P01732}.
-!- PTM: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following
activation. {ECO:0000250|UniProtKB:P01732}.
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EMBL; D16536; BAA03973.1; -; mRNA.
EMBL; AB000485; BAA19126.1; -; mRNA.
PIR; I46082; I46082.
RefSeq; NP_001009843.1; NM_001009843.2.
ProteinModelPortal; P41688; -.
SMR; P41688; -.
STRING; 9685.ENSFCAP00000013754; -.
GeneID; 493799; -.
KEGG; fca:493799; -.
CTD; 925; -.
eggNOG; ENOG410IWN3; Eukaryota.
eggNOG; ENOG410Z6EI; LUCA.
HOGENOM; HOG000004794; -.
HOVERGEN; HBG008488; -.
InParanoid; P41688; -.
KO; K06458; -.
TreeFam; TF336070; -.
Proteomes; UP000011712; Unplaced.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0045065; P:cytotoxic T cell differentiation; IBA:GO_Central.
GO; GO:0002456; P:T cell mediated immunity; IBA:GO_Central.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015468; CD8_asu.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
PANTHER; PTHR10441; PTHR10441; 1.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 1.
SMART; SM00406; IGv; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS50835; IG_LIKE; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunity; Immunoglobulin domain; Lipoprotein; Membrane;
Palmitate; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 239 T-cell surface glycoprotein CD8 alpha
chain.
/FTId=PRO_0000014637.
TOPO_DOM 22 188 Extracellular. {ECO:0000255}.
TRANSMEM 189 210 Helical. {ECO:0000255}.
TOPO_DOM 211 239 Cytoplasmic. {ECO:0000255}.
DOMAIN 25 139 Ig-like V-type.
LIPID 210 210 S-palmitoyl cysteine.
{ECO:0000250|UniProtKB:P01732}.
DISULFID 46 119 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 239 AA; 26120 MW; F9A171820E8FF1BC CRC64;
MASPVTAQLL PLALLLHAAA AAGPSPFRLS PVRVEGRLGQ RVELQCEVLL SSAAPGCTWL
FQKNEPAARP IFLAYLSRSR TKLAEELDPK QISGQRIQDT LYSLTLHRFR KEEEGYYFCS
VVSNSVLYFS AFVPVFLPVK PTTTPAPRPP TQAPITTSQR VSLRPGTCQP SAGSTVEASG
LDLSCDIYIW APLAGTCAFL LLSLVITVIC NHRNRRRVCK CPRPVVRAGG KPSPSERYV


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