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T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b)

 CD8B_SAISC              Reviewed;         209 AA.
Q9XSM7;
24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
25-OCT-2017, entry version 81.
RecName: Full=T-cell surface glycoprotein CD8 beta chain;
AltName: CD_antigen=CD8b;
Flags: Precursor;
Name=CD8B; Synonyms=CD8B1;
Saimiri sciureus (Common squirrel monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Saimiriinae; Saimiri.
NCBI_TaxID=9521;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Isolate 92039;
PubMed=10369934; DOI=10.1007/s002510050672;
Ureta-Vidal A., Garcia Z., Lemonnier F.A., Kazanji M.;
"Molecular characterization of cDNAs encoding squirrel monkey (Saimiri
sciureus) CD8 alpha and beta chains.";
Immunogenetics 49:718-721(1999).
-!- FUNCTION: Integral membrane glycoprotein that plays an essential
role in the immune response and serves multiple functions in
responses against both external and internal offenses. In T-cells,
functions primarily as a coreceptor for MHC class I
molecule:peptide complex. The antigens presented by class I
peptides are derived from cytosolic proteins while class II
derived from extracellular proteins. Interacts simultaneously with
the T-cell receptor (TCR) and the MHC class I proteins presented
by antigen presenting cells (APCs). In turn, recruits the Src
kinase LCK to the vicinity of the TCR-CD3 complex. A
palmitoylation site in the cytoplasmic tail of CD8B chain
contributes to partitioning of CD8 into the plasma membrane lipid
rafts where signaling proteins are enriched. Once LCK recruited,
it initiates different intracellular signaling pathways by
phosphorylating various substrates ultimately leading to
lymphokine production, motility, adhesion and activation of
cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical
role in thymic selection of CD8+ T-cells.
{ECO:0000250|UniProtKB:P10300, ECO:0000250|UniProtKB:P10966}.
-!- SUBUNIT: Forms disulfide-linked heterodimers with CD8A at the cell
surface. Interacts with CD3D; this interaction couples TCR-CD3
with CD8. Interacts with LCK. {ECO:0000250|UniProtKB:P10300,
ECO:0000250|UniProtKB:P10966}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P10966}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P10966}. Note=Requires the partner
CD8A for efficient cell surface expression. The heterodimer
CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail
palmitoylation. {ECO:0000250|UniProtKB:P10966}.
-!- PTM: Phosphorylated as a consequence of T-cell activation.
{ECO:0000250|UniProtKB:P10966}.
-!- PTM: Palmitoylated at the cytoplasmic tail and thereby targets the
heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.
{ECO:0000250|UniProtKB:P10966}.
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EMBL; AJ130819; CAB41463.1; -; mRNA.
ProteinModelPortal; Q9XSM7; -.
SMR; Q9XSM7; -.
HOVERGEN; HBG105700; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 1.
SMART; SM00406; IGv; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS50835; IG_LIKE; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Disulfide bond; Glycoprotein;
Immunity; Immunoglobulin domain; Lipoprotein; Membrane; Palmitate;
Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 209 T-cell surface glycoprotein CD8 beta
chain.
/FTId=PRO_0000014647.
TOPO_DOM 22 169 Extracellular. {ECO:0000255}.
TRANSMEM 170 190 Helical. {ECO:0000255}.
TOPO_DOM 191 209 Cytoplasmic. {ECO:0000255}.
DOMAIN 22 131 Ig-like V-type.
CARBOHYD 101 101 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 41 115 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 209 AA; 23481 MW; E595E8E39DF629C5 CRC64;
MRPRMWLLLS AQLAALHGNS VLQQTPAYIM VQTNQMVMLS CKAISSSTTR IYWLRQLHAP
SSNSHHEILA FWDSSKGTIH SEGVEQKKIT VFRDGSLFFL NLTRVKLEDS GTYFCMVIGS
PTLIFGTGTQ LSVVDILPTT AQTTKKSTPK KTVCRLPRPE TRKGPLCSPI TLSLLVAGIL
VLLVSLGVAI HLYCRQRRAR LRFMKQFYK


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