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T-cell-specific surface glycoprotein CD28 homolog (CHT28)

 CD28_CHICK              Reviewed;         221 AA.
P31043;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
10-MAY-2017, entry version 120.
RecName: Full=T-cell-specific surface glycoprotein CD28 homolog;
AltName: Full=CHT28;
Flags: Precursor;
Name=CD28;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=White leghorn; TISSUE=Spleen;
PubMed=8144954;
Young J.R., Davison T.F., Tregaskes C.A., Rennie M.C., Vainio O.;
"Monomeric homologue of mammalian CD28 is expressed on chicken T
cells.";
J. Immunol. 152:3848-3851(1994).
-!- FUNCTION: Possibly involved in T-cell activation.
{ECO:0000250|UniProtKB:P10747}.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-----------------------------------------------------------------------
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EMBL; X67915; CAA48114.1; -; mRNA.
PIR; I50619; S25168.
RefSeq; NP_990642.1; NM_205311.1.
UniGene; Gga.723; -.
ProteinModelPortal; P31043; -.
SMR; P31043; -.
STRING; 9031.ENSGALP00000014099; -.
PaxDb; P31043; -.
Ensembl; ENSGALT00000014115; ENSGALP00000014099; ENSGALG00000008669.
GeneID; 396249; -.
KEGG; gga:396249; -.
CTD; 940; -.
eggNOG; ENOG410IXMM; Eukaryota.
eggNOG; ENOG410Z063; LUCA.
GeneTree; ENSGT00530000063873; -.
HOGENOM; HOG000276892; -.
HOVERGEN; HBG004094; -.
InParanoid; P31043; -.
KO; K06470; -.
OMA; VNGNYSH; -.
OrthoDB; EOG091G0IGY; -.
PhylomeDB; P31043; -.
TreeFam; TF335679; -.
Reactome; R-GGA-1257604; PIP3 activates AKT signaling.
Reactome; R-GGA-389356; CD28 co-stimulation.
Reactome; R-GGA-389357; CD28 dependent PI3K/Akt signaling.
Reactome; R-GGA-389359; CD28 dependent Vav1 pathway.
Reactome; R-GGA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
PRO; PR:P31043; -.
Proteomes; UP000000539; Chromosome 7.
Bgee; ENSGALG00000008669; -.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
GO; GO:0098636; C:protein complex involved in cell adhesion; IEA:Ensembl.
GO; GO:0044214; C:spanning component of plasma membrane; ISS:AgBase.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0045060; P:negative thymic T cell selection; IEA:Ensembl.
GO; GO:0046641; P:positive regulation of alpha-beta T cell proliferation; IEA:Ensembl.
GO; GO:0002863; P:positive regulation of inflammatory response to antigenic stimulus; IEA:Ensembl.
GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0045589; P:regulation of regulatory T cell differentiation; IEA:Ensembl.
GO; GO:0045066; P:regulatory T cell differentiation; IEA:Ensembl.
GO; GO:0031295; P:T cell costimulation; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR008093; CD28.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR013106; Ig_V-set.
Pfam; PF15910; V-set_2; 1.
PRINTS; PR01717; CD28ANTIGEN.
SUPFAM; SSF48726; SSF48726; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Reference proteome; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 13 {ECO:0000255}.
CHAIN 14 221 T-cell-specific surface glycoprotein CD28
homolog.
/FTId=PRO_0000014656.
TOPO_DOM 14 149 Extracellular. {ECO:0000255}.
TRANSMEM 150 174 Helical. {ECO:0000255}.
TOPO_DOM 175 221 Cytoplasmic. {ECO:0000255}.
DOMAIN 28 137 Ig-like V-type.
CARBOHYD 33 33 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 41 41 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 45 45 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 71 71 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 100 100 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 128 128 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 40 111 {ECO:0000250}.
DISULFID 66 85 {ECO:0000250}.
SEQUENCE 221 AA; 25401 MW; 60245A3D493CF109 CRC64;
MLGILVVLCL IPAADVTENK ILVAQRPLLI VANRTATLVC NYTYNGTGKE FRASLHKGTD
SAVEVCFISW NMTKINSNSN KEFNCRGIHD KDKVIFNLWN MSASQTDIYF CKIEAMYPPP
YVYNEKSNGT VIHVRETPIQ TQEPESATSY WVMVAVTGLL GFYSMLITAV FIIYRQKSKR
NRYRQSDYMN MTPRHPPHQK NKGYPSYAPT RDYTAYRSWQ P


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