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T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (CD antigen CD86)

 CD86_RABIT              Reviewed;         330 AA.
P42071;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
28-FEB-2018, entry version 102.
RecName: Full=T-lymphocyte activation antigen CD86;
AltName: Full=Activation B7-2 antigen;
AltName: CD_antigen=CD86;
Flags: Precursor;
Name=CD86;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=B/J X Chbb:HM;
PubMed=7642234; DOI=10.1007/BF00191228;
Isono T., Seto A.;
"Cloning and sequencing of the rabbit gene encoding T-cell
costimulatory molecules.";
Immunogenetics 42:217-220(1995).
-!- FUNCTION: Receptor involved in the costimulatory signal essential
for T-lymphocyte proliferation and interleukin-2 production, by
binding CD28 or CTLA-4. May play a critical role in the early
events of T-cell activation and costimulation of naive T-cells,
such as deciding between immunity and anergy that is made by T-
cells within 24 hours after activation.
-!- SUBUNIT: Homodimer. Interacts with MARCH8 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}.
-!- PTM: Polyubiquitinated; which is promoted by MARCH8 and results in
endocytosis and lysosomal degradation. {ECO:0000250}.
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EMBL; D49842; BAA08642.1; -; mRNA.
PIR; I46691; I46691.
RefSeq; NP_001075677.1; NM_001082208.1.
UniGene; Ocu.3058; -.
ProteinModelPortal; P42071; -.
STRING; 9986.ENSOCUP00000009930; -.
GeneID; 100008999; -.
KEGG; ocu:100008999; -.
CTD; 942; -.
eggNOG; ENOG410IYP1; Eukaryota.
eggNOG; ENOG410ZD66; LUCA.
HOGENOM; HOG000276893; -.
HOVERGEN; HBG004093; -.
InParanoid; P42071; -.
KO; K05413; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
CDD; cd16087; IgV_CD86; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR037677; CD86_IgV.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 1.
SMART; SM00406; IGv; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00290; IG_MHC; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Receptor;
Reference proteome; Signal; Transmembrane; Transmembrane helix;
Ubl conjugation.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 330 T-lymphocyte activation antigen CD86.
/FTId=PRO_0000014552.
TOPO_DOM 23 247 Extracellular. {ECO:0000255}.
TRANSMEM 248 268 Helical. {ECO:0000255}.
TOPO_DOM 269 330 Cytoplasmic. {ECO:0000255}.
DOMAIN 33 127 Ig-like V-type.
DOMAIN 150 225 Ig-like C2-type.
CARBOHYD 33 33 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 135 135 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 146 146 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 154 154 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 177 177 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 192 192 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 198 198 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 213 213 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 40 110 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 157 218 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 330 AA; 37143 MW; 935CDD65C57E3EE1 CRC64;
MDAGCTMGLS VTVFVMALLL SGAASLRIQA YFNKTADLPC QFTNSQSRSL SELVVFWQDQ
ERLVLYELFL GREKPDNVDP KYIGRTSFDQ ESWNLQLHNV QIKDKGVYQC FVHHRGAKGL
VPIYQMNSEL SVLANFTQPE ITLISNITRN SAINLTCSSV QGYPEPKKMF FVLKTENATT
EYDGVIEKSQ DNVTGLYNIS ISGSITFSDD IRNATIYCVL QTESTETYSQ HFPIVPADPV
PVEKPRLWIA AVALTLIVVC GIVLFLTLWK RKKEQQPGVC ECETIKMDKA ENEHVEERVK
IHEPEKIPAK AAKCEHRLKT PSSDKSAAHF


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