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TATA-box-binding protein 1 (EhTBP) (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)

 TBP1_ENTHI              Reviewed;         234 AA.
P52653; B1N4X3;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
15-DEC-1998, sequence version 2.
28-MAR-2018, entry version 85.
RecName: Full=TATA-box-binding protein 1;
Short=EhTBP;
AltName: Full=TATA sequence-binding protein;
AltName: Full=TATA-binding factor;
AltName: Full=TATA-box factor;
AltName: Full=Transcription initiation factor TFIID TBP subunit;
Name=TBP; ORFNames=EHI_020610;
Entamoeba histolytica.
Eukaryota; Amoebozoa; Archamoebae; Entamoebidae; Entamoeba.
NCBI_TaxID=5759;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 30459 / HM-1:IMSS;
PubMed=9033007;
Hernandez R., Luna-Arias J.P., Orozco E.;
"Comparison of the Entamoeba histolytica TATA-binding protein (TBP)
structure with other TBP.";
Arch. Med. Res. 28:43-45(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 30459 / HM-1:IMSS;
PubMed=15729342; DOI=10.1038/nature03291;
Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J.,
Amedeo P., Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T.,
Suh B., Pop M., Duchene M., Ackers J., Tannich E., Leippe M.,
Hofer M., Bruchhaus I., Willhoeft U., Bhattacharya A.,
Chillingworth T., Churcher C.M., Hance Z., Harris B., Harris D.,
Jagels K., Moule S., Mungall K.L., Ormond D., Squares R.,
Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H., Price C.,
Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S.,
Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U.,
Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M.,
Barrell B.G., Fraser C.M., Hall N.;
"The genome of the protist parasite Entamoeba histolytica.";
Nature 433:865-868(2005).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 30459 / HM-1:IMSS;
Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.;
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
[4]
FUNCTION.
PubMed=20026212; DOI=10.1016/j.pep.2009.12.007;
Castanon-Sanchez C.A., Luna-Arias J.P., de Dios-Bravo M.G.,
Herrera-Aguirre M.E., Olivares-Trejo J.J., Orozco E., Hernandez J.M.;
"Entamoeba histolytica: a unicellular organism containing two active
genes encoding for members of the TBP family.";
Protein Expr. Purif. 70:48-59(2010).
-!- FUNCTION: General transcription factor that functions at the core
of the DNA-binding multiprotein factor TFIID. Binding of TFIID to
the TATA box is the initial transcriptional step of the pre-
initiation complex (PIC), playing a role in the activation of
eukaryotic genes transcribed by RNA polymerase II.
{ECO:0000269|PubMed:20026212}.
-!- SUBUNIT: Belongs to the TFIID complex together with the TBP-
associated factors (TAFs). Binds DNA as monomer.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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EMBL; Z48307; CAA88304.1; -; Genomic_DNA.
EMBL; DS571521; EDS88986.1; -; Genomic_DNA.
RefSeq; XP_001914239.1; XM_001914204.1.
ProteinModelPortal; P52653; -.
SMR; P52653; -.
STRING; 5759.rna_EHI_020610-1; -.
GeneID; 6220268; -.
KEGG; ehi:EHI_020610; -.
EuPathDB; AmoebaDB:EHI_020610; -.
eggNOG; KOG3302; Eukaryota.
eggNOG; COG2101; LUCA.
InParanoid; P52653; -.
KO; K03120; -.
OMA; VYRMDEP; -.
Proteomes; UP000001926; Partially assembled WGS sequence.
GO; GO:0005669; C:transcription factor TFIID complex; IC:UniProtKB.
GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.
GO; GO:0006366; P:transcription by RNA polymerase II; IDA:UniProtKB.
CDD; cd04516; TBP_eukaryotes; 1.
Gene3D; 3.30.310.10; -; 3.
HAMAP; MF_00408; TATA_bind_prot_arch; 1.
InterPro; IPR000814; TBP.
InterPro; IPR030491; TBP_CS.
InterPro; IPR012295; TBP_dom_sf.
InterPro; IPR033710; TBP_eukaryotic.
PANTHER; PTHR10126; PTHR10126; 1.
Pfam; PF00352; TBP; 2.
PRINTS; PR00686; TIFACTORIID.
PROSITE; PS00351; TFIID; 1.
3: Inferred from homology;
Complete proteome; DNA-binding; Nucleus; Reference proteome; Repeat;
Transcription; Transcription regulation.
CHAIN 1 234 TATA-box-binding protein 1.
/FTId=PRO_0000153972.
REPEAT 52 136 1.
REPEAT 142 223 2.
SEQUENCE 234 AA; 25967 MW; FD2EFF20C1DBCB30 CRC64;
MSTPGDFSLS PFILGGAVDP RSMSQLGNIC HADYMSTSTE SQERSLNNPN DTHPEIVNVV
STFQLGVKLE LRKIVQKARN AEYNPKRFAG AIMRISSPKS TALIFQTGKI VCTGTRSIEE
SKIASKKYAK IIKKIGYPIH YSNFNVQNIV GSCDVKFQIA LRTLVDSYLA FCQYEPEVFP
GLVYRMASPK VTLLVFSTGK VVLTGAKDEE SLNLAYKNIY PILLANRKED ISNQ


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