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TBC1 domain family member 14 (Spermatogenesis-related factor 2) (SRF-2) (Up-regulated in nephrectomized rat kidney #2)

 TBC14_RAT               Reviewed;         694 AA.
Q5CD77; Q499U3; Q6I7R4;
26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
26-FEB-2008, sequence version 2.
23-MAY-2018, entry version 72.
RecName: Full=TBC1 domain family member 14;
AltName: Full=Spermatogenesis-related factor 2;
Short=SRF-2;
AltName: Full=Up-regulated in nephrectomized rat kidney #2;
Name=Tbc1d14; ORFNames=UR-NR#2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
STRAIN=Sprague-Dawley; TISSUE=Testis;
PubMed=15758561; DOI=10.1507/endocrj.52.75;
Yamano Y., Ohyama K., Ohta M., Sano T., Ritani A., Shimada J.,
Ashida N., Yoshida E., Ikehara K., Morishima I.;
"A novel spermatogenesis related factor-2 (SRF-2) gene expression
affected by TCDD treatment.";
Endocr. J. 52:75-81(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 278-694, TISSUE SPECIFICITY, AND
INDUCTION.
STRAIN=Wistar; TISSUE=Kidney;
PubMed=15200410; DOI=10.1111/j.1523-1755.2004.00704.x;
Horiba N., Masuda S., Takeuchi A., Saito H., Okuda M., Inui K.;
"Gene expression variance based on random sequencing in rat remnant
kidney.";
Kidney Int. 66:29-45(2004).
-!- FUNCTION: Negative regulator of starvation-induced autophagosome
formation. {ECO:0000250}.
-!- SUBUNIT: Interacts with ULK1. May interact with RAB11A and RAB11B,
but does not exhibit any GTPase-activating activity toward these
proteins (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network
{ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}.
Note=After amino acid starvation, Golgi apparatus-associated
protein levels increase compared with fed conditions. May be
cycling between the Golgi apparatus and an endosomal pool,
redistributing to the Golgi apparatus upon starvation (By
similarity). {ECO:0000250}.
-!- TISSUE SPECIFICITY: PubMed:15758561 detected expression at the
stage of sexual maturation in testis, mainly in the spermatocytes.
No expression detected in the ovary, brain, heart, lung, liver and
kidney. PubMed:15200410 detected expression in brain, heart, lung,
liver, spleen and kidney but not in small intestine.
{ECO:0000269|PubMed:15200410, ECO:0000269|PubMed:15758561}.
-!- DEVELOPMENTAL STAGE: First detected in the testis at 5 weeks.
Level of expression increases up to 7 weeks and maintains even at
63 weeks. {ECO:0000269|PubMed:15758561}.
-!- INDUCTION: Up-regulated in nephrectomized kidney.
{ECO:0000269|PubMed:15200410}.
-!- SEQUENCE CAUTION:
Sequence=AAH99760.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAD23893.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAD91010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Sequence=BAD91010.1; Type=Frameshift; Positions=645; Evidence={ECO:0000305};
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EMBL; AB117752; BAD91010.1; ALT_SEQ; mRNA.
EMBL; BC099760; AAH99760.1; ALT_INIT; mRNA.
EMBL; AB108668; BAD23893.1; ALT_INIT; mRNA.
RefSeq; NP_001012152.2; NM_001012152.2.
RefSeq; NP_001029193.2; NM_001034021.2.
RefSeq; NP_001106836.1; NM_001113365.1.
UniGene; Rn.203187; -.
ProteinModelPortal; Q5CD77; -.
SMR; Q5CD77; -.
STRING; 10116.ENSRNOP00000055215; -.
PhosphoSitePlus; Q5CD77; -.
PaxDb; Q5CD77; -.
PRIDE; Q5CD77; -.
GeneID; 360956; -.
KEGG; rno:360956; -.
CTD; 57533; -.
RGD; 1309993; Tbc1d14.
eggNOG; KOG2223; Eukaryota.
eggNOG; COG5210; LUCA.
HOGENOM; HOG000016604; -.
HOVERGEN; HBG061665; -.
InParanoid; Q5CD77; -.
KO; K20167; -.
PhylomeDB; Q5CD77; -.
PRO; PR:Q5CD77; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005776; C:autophagosome; IBA:GO_Central.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
GO; GO:0017137; F:Rab GTPase binding; IBA:GO_Central.
GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
GO; GO:2000785; P:regulation of autophagosome assembly; IBA:GO_Central.
GO; GO:0031338; P:regulation of vesicle fusion; IBA:GO_Central.
InterPro; IPR000195; Rab-GTPase-TBC_dom.
InterPro; IPR035969; Rab-GTPase_TBC_sf.
Pfam; PF00566; RabGAP-TBC; 1.
SMART; SM00164; TBC; 1.
SUPFAM; SSF47923; SSF47923; 2.
PROSITE; PS50086; TBC_RABGAP; 1.
2: Evidence at transcript level;
Complete proteome; Golgi apparatus; GTPase activation; Phosphoprotein;
Reference proteome.
CHAIN 1 694 TBC1 domain family member 14.
/FTId=PRO_0000319418.
DOMAIN 402 612 Rab-GAP TBC. {ECO:0000255|PROSITE-
ProRule:PRU00163}.
MOD_RES 92 92 Phosphoserine.
{ECO:0000250|UniProtKB:Q9P2M4}.
MOD_RES 296 296 Phosphoserine.
{ECO:0000250|UniProtKB:Q9P2M4}.
CONFLICT 278 282 KKTQK -> GLASM (in Ref. 3; BAD23893).
{ECO:0000305}.
CONFLICT 304 304 N -> S (in Ref. 3; BAD23893).
{ECO:0000305}.
CONFLICT 416 416 I -> M (in Ref. 3; BAD23893).
{ECO:0000305}.
CONFLICT 420 420 L -> V (in Ref. 3; BAD23893).
{ECO:0000305}.
CONFLICT 431 431 L -> F (in Ref. 3; BAD23893).
{ECO:0000305}.
SEQUENCE 694 AA; 78209 MW; 6DAE2A6B5F47AA1F CRC64;
MTDGNLSTSM NGVALMGILD GRPGDSLQEL QHLSIKAVPR SLSVPDYGPT LKLGALEDRH
SLQSVDSGIP TLEIGNPEPV PCSVVHVKRK QSESEIIPER AFQSACPLPS CTPSAPTGSE
REQAVRKSST FPRTGYDSVK LYSPTSKALS RSDDVSVCSV SSLGTELSTT LSVSNEDILD
LMVTSNSSAI VTLENDDDPQ FTDVTLSSIK ETSDLHQQDC VAETEEGRKL RLLQPFSHFF
TRNLLARKQN ARLDRQRDLG WKLFGKVPLR ETAQKDSKKT QKEYEDKAGR PSRPPSPKQN
VRKNLDFEPL STTALILEDR PANLPAKPAE EAQKHRQQYE EMVVQAKKRE LKEAQRRKKQ
LEERCKVEES IGNAVLTWNN EILPNWETMW CSKKVRDLWW QGIPPSVRGK VWSLAIGNEL
NITHELFDIC LARAKERWRS LSTGGSEVEN EDAGFSAADR EASLELIKLD ISRTFPNLCI
FQQGGPYHDM LHSILGAYTC YRPDVGYVQG MSFIAAVLIL NLDTADAFIA FSNLLNKPCQ
MAFFRVDHGL MLTYFAAFEV FFEENLPKLF AHFKKNNLTA DIYLIDWIFT LYSKSLPLDL
ACRIWDVFCR DGEEFLFRTA LGILKLFEDI LTRMDFIHSA QFLTRLPEDL PADDVFAAIS
TVQMQSRNKK WAQVLSALQK DSREMEEGSP SVRD


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