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TEK receptor tyrosine kinase

 F6XN02_CALJA            Unreviewed;      1116 AA.
F6XN02;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
22-NOV-2017, entry version 53.
SubName: Full=TEK receptor tyrosine kinase {ECO:0000313|Ensembl:ENSCJAP00000034130};
Name=TEK {ECO:0000313|Ensembl:ENSCJAP00000034130};
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000034130, ECO:0000313|Proteomes:UP000008225};
[1] {ECO:0000313|Ensembl:ENSCJAP00000034130, ECO:0000313|Proteomes:UP000008225}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCJAP00000034130}
IDENTIFICATION.
Ensembl;
Submitted (JUN-2011) to UniProtKB.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000256|SAAS:SAAS00701269}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000256|SAAS:SAAS00941529}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000034130}.
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EMBL; ACFV01147540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01147541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01147542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01147543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01147544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01147545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01147546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01147547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01147548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01147549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; F6XN02; -.
STRING; 9483.ENSCJAP00000034130; -.
Ensembl; ENSCJAT00000036054; ENSCJAP00000034130; ENSCJAG00000018394.
eggNOG; KOG0200; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00810000125384; -.
InParanoid; F6XN02; -.
OMA; AIEYAPH; -.
OrthoDB; EOG091G00RL; -.
TreeFam; TF317568; -.
Proteomes; UP000008225; Chromosome 1.
GO; GO:0005884; C:actin filament; IEA:Ensembl.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0005815; C:microtubule organizing center; IEA:Ensembl.
GO; GO:0005902; C:microvillus; IEA:Ensembl.
GO; GO:0001725; C:stress fiber; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0051894; P:positive regulation of focal adhesion assembly; IEA:Ensembl.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0051259; P:protein oligomerization; IEA:Ensembl.
GO; GO:0032878; P:regulation of establishment or maintenance of cell polarity; IEA:Ensembl.
GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0048014; P:Tie signaling pathway; IEA:Ensembl.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR018941; Tyr_kin_Tie2_Ig-like_dom-1_N.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
Pfam; PF00041; fn3; 1.
Pfam; PF10430; Ig_Tie2_1; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00181; EGF; 3.
SMART; SM00060; FN3; 1.
SMART; SM00220; S_TKc; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF49265; SSF49265; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00022; EGF_1; 2.
PROSITE; PS50026; EGF_3; 2.
PROSITE; PS50853; FN3; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|SAAS:SAAS00708816};
Complete proteome {ECO:0000313|Proteomes:UP000008225};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
Kinase {ECO:0000256|SAAS:SAAS00582553};
Membrane {ECO:0000256|SAAS:SAAS00602683, ECO:0000256|SAM:Phobius};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00708816};
Receptor {ECO:0000256|SAAS:SAAS00600436};
Reference proteome {ECO:0000313|Proteomes:UP000008225};
Transferase {ECO:0000256|SAAS:SAAS00582553};
Transmembrane {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
TRANSMEM 738 762 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 215 251 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 264 298 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 633 727 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 816 1088 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DISULFID 241 250 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 288 297 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 1116 AA; 125475 MW; 829612F4A0FA7202 CRC64;
LWGHVNNLRS NILSLLGAVE GAMDLILINS LPLVSDDETS LTCIASGWHP HEPFTIGRDF
EALMNQHQDP LEVTQDMTRE WAKKVVWKRE KASKINGAYF CEGRVRGKAI KIRTMKMRQQ
ASFLPTTLTM TVDKGDNVNI TFRKVLIKEE DAVVYRNSSF IHSVPRHEIP DILEINLPYA
QPQDAGVYSA RYIGGNLFTS SFTRLIVRRC EAQKWGPECN RRCTACMNNG VCHEDTGECI
CPPGFMGRTC EKACELHTFG RTCNERCSGQ DGCKSYVICL PDPYGCSCAT GWKGLQCSEA
CPPGFYGPDC KLRCSCSNGE MCDRFRGCLC SPGRQGVQCE REGKASDRKS KINRKDYAQN
EIESANFNPQ TKSSPLHSPE ICILKLKEAD ICIFKLKYFN HININAIEIN ISSEIYTQNN
TAWTLLQNRN QGVVRKFPSA VAAKEVPSDG RISKINTSSY KICVGSQPSN SIWSKGKKWS
ELDLAYHPNH IKNNICVLGF LVGKHLPGEC LPLVSLDGQP TASKQFTSVR SQLRRLTIIS
NFITSHNRTF HYIGFPPAHQ NHLIIVLAIS TDRQEAVPLM APMFSTAPFF LLVLVHVQPE
ESLLLIDHLE VGLKNNGVWN ETAYVYYSFL PPQPEKIKIS NITHSSAVIS WTILDGYSIS
SITIRYKVQG KNEDQHIDVK IKNATITQYQ LKGLEPETAY HVDIFAENNI GSSKPAFSHE
LVTLPESPAP ADLSGGKMLL IAILGSAGMT CLTVLLAFLI MLQLKRANVQ RRMAQAFQNV
REEPAVQFNS GTLALNRKVK SNPDPRIYPV LDWNDIKFQD VIGEGNFGQV LKARIKKDGL
RMDAAIKRMK EYASKDDHRD FAGELEVLCK LGHHPNIINL LGACEHRGYL YLAIEYAPHG
NLLDFLRKSR VLETDPAFAI ANSTASTLSS QQLLHFAADV ARGMDYLSQK QFIHRDLAAR
NILVGENYIA KIADFGLSRG QEVYVKKTMG RLPVRWMAIE SLNYSVYTTN SDVWSYGVLL
WEIVSLGGTP YCGMTCAELY EKLPQGYRLE KPLNCDDEVY DLMRQCWREK PYERPSFAQI
LVSLNRMLEE RKTYVNTTLY EKFTYAGIDC SAEEAA


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