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TEK receptor tyrosine kinase

 H0YT27_TAEGU            Unreviewed;      1128 AA.
H0YT27;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
25-OCT-2017, entry version 50.
SubName: Full=TEK receptor tyrosine kinase {ECO:0000313|Ensembl:ENSTGUP00000001438};
Name=TEK {ECO:0000313|Ensembl:ENSTGUP00000001438};
Taeniopygia guttata (Zebra finch) (Poephila guttata).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
Estrildidae; Estrildinae; Taeniopygia.
NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000001438, ECO:0000313|Proteomes:UP000007754};
[1] {ECO:0000313|Ensembl:ENSTGUP00000001438, ECO:0000313|Proteomes:UP000007754}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20360741; DOI=10.1038/nature08819;
Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
"The genome of a songbird.";
Nature 464:757-762(2010).
[2] {ECO:0000313|Ensembl:ENSTGUP00000001438}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2012) to UniProtKB.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000256|SAAS:SAAS00701269}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000256|SAAS:SAAS00941529}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSTGUP00000001438}.
-----------------------------------------------------------------------
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EMBL; ABQF01035746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABQF01035747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; H0YT27; -.
STRING; 59729.ENSTGUP00000001438; -.
Ensembl; ENSTGUT00000001451; ENSTGUP00000001438; ENSTGUG00000001382.
eggNOG; KOG0200; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00810000125384; -.
InParanoid; H0YT27; -.
OMA; AIEYAPH; -.
OrthoDB; EOG091G00RL; -.
TreeFam; TF317568; -.
Reactome; R-TGU-210993; Tie2 Signaling.
Reactome; R-TGU-5673001; RAF/MAP kinase cascade.
Proteomes; UP000007754; Chromosome Z.
GO; GO:0005884; C:actin filament; IEA:Ensembl.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0005815; C:microtubule organizing center; IEA:Ensembl.
GO; GO:0005902; C:microvillus; IEA:Ensembl.
GO; GO:0001725; C:stress fiber; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0051894; P:positive regulation of focal adhesion assembly; IEA:Ensembl.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0051259; P:protein oligomerization; IEA:Ensembl.
GO; GO:0032878; P:regulation of establishment or maintenance of cell polarity; IEA:Ensembl.
GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0048014; P:Tie signaling pathway; IEA:Ensembl.
CDD; cd00063; FN3; 2.
Gene3D; 2.60.40.10; -; 6.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR011009; Kinase-like_dom.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR018941; Tyr_kin_Tie2_Ig-like_dom-1_N.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
Pfam; PF00041; fn3; 3.
Pfam; PF10430; Ig_Tie2_1; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00181; EGF; 3.
SMART; SM00060; FN3; 3.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF49265; SSF49265; 2.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00022; EGF_1; 3.
PROSITE; PS01186; EGF_2; 1.
PROSITE; PS50026; EGF_3; 2.
PROSITE; PS50853; FN3; 3.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|SAAS:SAAS00708816};
Complete proteome {ECO:0000313|Proteomes:UP000007754};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
Immunoglobulin domain {ECO:0000256|SAAS:SAAS00941986};
Kinase {ECO:0000256|SAAS:SAAS00582553};
Membrane {ECO:0000256|SAAS:SAAS00602683, ECO:0000256|SAM:Phobius};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00708816};
Receptor {ECO:0000256|SAAS:SAAS00600436};
Reference proteome {ECO:0000313|Proteomes:UP000007754};
Signal {ECO:0000256|SAM:SignalP};
Transferase {ECO:0000256|SAAS:SAAS00582553};
Transmembrane {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
SIGNAL 1 23 {ECO:0000256|SAM:SignalP}.
CHAIN 24 1128 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003546623.
TRANSMEM 750 774 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 217 253 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 308 342 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 351 441 Ig-like. {ECO:0000259|PROSITE:PS50835}.
DOMAIN 448 542 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 546 640 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 645 738 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 828 1100 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DISULFID 243 252 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 332 341 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 1128 AA; 126121 MW; 75BFD14CA4882871 CRC64;
SMDPLAHLVL YGFSLLISGK VEAALDLILI NSFPLVGNSE TSLICVTSKW HSRESITIGR
DQEGVANQHR EPLEVNEDSK RAAAKTVVWK REQASETIGA YYCEGKLKDE VTRIHTMKMP
LGASFYPVAL TVTANKGEHV NISFIRMASK EEDAVIYKNG SFIHSVPRHE VPGELEVSYP
QVQPQDAGVY SARYIGGNLF TSAYTRLIVR RCEAEKWGPS CSFHCPSCTN NGICHEDTGE
CICPPGFMGK TCEKACGANT FGKTCEETCK ENYGCRNFMF CLPDPYGCSC ATGWMGLECD
KECTPGFYGS DCKLKCNCHN RGTCNRFKGC ICSFGWHGPQ CEKKGSADLS PQIVNLLDPV
ELNSGVEFKP FCIATGMPLP KSEEFKLLKQ DGTVLKPDEI STSNHSEAMF RINRVLPGDT
GTWVCSVQTV AGMAEKPFQV TVKVPPVPQY APRLTDRGHN FLVIDINAEL HYGDGPVVST
KLLYKPEKRY QSWMSVEVKG TTKRLDNLEP KTEYQFCVQL SRQGEGGEGH PGPQASFTTA
ALGLPPPEGI TLFPKSMTSL NLSWHPLTLR TEDDIRVEVE RKTVNDNDDK SSVITQVPGN
MSTLIIKDLE PRQQYMCRVR VNTRSQGEWS NYLYAWTFSD RIPPAPNNIR FSNITDTSSV
ISWTAAEGHS ISSIIISYKI YGKAEYNHID IIIKNTSITQ YHLKGLEPDT VYQVQINAQN
NIGLSNPNTS FELKTLPETK ASYESKGGKM LLIAILGSAG MTCVTILLAF LIMLQLKRAN
FQHRMAQAFQ NVREEPALQF NSGTLTLSRK AKTSPDPTVY PVLEWNDIKF QDVIGEGNFG
QVLKARIKKD GLRMDAAIKR MKEYASKDDH RDFAGELEVL CKLGHHPNII NLLGACEHRG
YLYLAIEYAP HGNLLDFLRK SRVLETDPAF AIANSTASTL SSQQLLHFAA DVARGMDYLS
QKQFIHRDLA ARNILVGENY VAKIADFGLS RGQEVYVKKT MGRLPVRWMA IESLNYSVYT
TNSDVWSYGV LLWEIVSLGG TPYCGMTCAE LYEKLPQGYR LEKPLNCDDE VYDLMRQCWK
EKPYERPSFA QILVSLNRML EDRKTYVNTT LYEKFTYAGI DCSAEEAA


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