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TIMELESS isoform 1 (Timeless circadian regulator) (Timeless homolog)

 H2R1D2_PANTR            Unreviewed;      1209 AA.
H2R1D2; A0A2J8Q1R8;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
12-SEP-2018, entry version 38.
SubName: Full=TIMELESS isoform 1 {ECO:0000313|EMBL:PNI90203.1};
SubName: Full=Timeless circadian regulator {ECO:0000313|Ensembl:ENSPTRP00000042163};
SubName: Full=Timeless homolog {ECO:0000313|EMBL:JAA03064.1};
Name=TIMELESS {ECO:0000313|EMBL:JAA03064.1,
ECO:0000313|Ensembl:ENSPTRP00000042163, ECO:0000313|VGNC:VGNC:5623};
ORFNames=CK820_G0046623 {ECO:0000313|EMBL:PNI90203.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000042163, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000042163, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000042163}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:JAA03064.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03064.1},
Skeletal muscle {ECO:0000313|EMBL:JAA39590.1},
Skin {ECO:0000313|EMBL:JAA24061.1}, and
Smooth vascular {ECO:0000313|EMBL:JAA14011.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from
NextGen mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:PNI90203.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI90203.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI90203.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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EMBL; AACZ04012964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ04012965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GABC01008274; JAA03064.1; -; mRNA.
EMBL; GABF01008134; JAA14011.1; -; mRNA.
EMBL; GABD01009039; JAA24061.1; -; mRNA.
EMBL; GABE01005149; JAA39590.1; -; mRNA.
EMBL; NBAG03000092; PNI90203.1; -; Genomic_DNA.
RefSeq; XP_509535.2; XM_509535.5.
STRING; 9598.ENSPTRP00000042163; -.
Ensembl; ENSPTRT00000050973; ENSPTRP00000042163; ENSPTRG00000022963.
GeneID; 452431; -.
CTD; 8914; -.
VGNC; VGNC:5623; TIMELESS.
eggNOG; KOG1974; Eukaryota.
eggNOG; ENOG410XQM6; LUCA.
GeneTree; ENSGT00390000015124; -.
OMA; LQRGNRH; -.
OrthoDB; EOG091G00YS; -.
TreeFam; TF312802; -.
Proteomes; UP000002277; Chromosome 12.
Bgee; ENSPTRG00000022963; Expressed in 6 organ(s), highest expression level in liver.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
GO; GO:0044770; P:cell cycle phase transition; IEA:Ensembl.
GO; GO:1904976; P:cellular response to bleomycin; IEA:Ensembl.
GO; GO:0072719; P:cellular response to cisplatin; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0072711; P:cellular response to hydroxyurea; IEA:Ensembl.
GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:Ensembl.
GO; GO:0042752; P:regulation of circadian rhythm; IEA:Ensembl.
InterPro; IPR006906; Timeless.
InterPro; IPR007725; TIMELESS_C.
Pfam; PF04821; TIMELESS; 1.
Pfam; PF05029; TIMELESS_C; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Reference proteome {ECO:0000313|Proteomes:UP000002277}.
DOMAIN 24 284 TIMELESS. {ECO:0000259|Pfam:PF04821}.
DOMAIN 729 1180 TIMELESS_C. {ECO:0000259|Pfam:PF05029}.
COILED 663 688 {ECO:0000256|SAM:Coils}.
SEQUENCE 1209 AA; 138930 MW; AD0A6A6B2C48F5DD CRC64;
MDLHMMNCEL LATCSALGYL EGDTYHKEPD CLESVKDLIR YLRHEDETRD VRQQLGAAQI
LQSDLLPILT QHHQDKPLFD AVIRLMVNLT QPALLCFGNL PKEPSFRHHF LQVLTYLQAY
KEAFASEKAF GVLSETLYEL LQLGWEERQE EDNLLIERIL LLVRNILHVP ADLDQEKKID
DDASAHDQLL WAIHLSGLDD LLLFLASSSA EEQWSLHVLE IVSLMFRDQN PEQLAGVGQG
RLAQERSADF AELEVLRQRE MAEKKTRALQ RGNRHSRFGG SYIVQGLKSI GERDLIFHKG
LHNLRNYSSD LGKQPKKVPK RRQAARELSI QRRSALNVRL FLRDFCSEFL ENCYNRLMGS
VKDHLLREKA QQYDETYYMW ALAFFMAFNR AASFRPGLVS ETLSVRTFHF IEQNLTNYYE
MMLTDRKEAA SWARRMHLAL KAYQELLATV NEMDISPDEA VRESSRIIKN NIFYVMEYRE
LFLALFRKFD ERCQPRSFLR DLVETTHLFL KMLERFCRSR GNLVVQNKQK KRRKKKKKVL
DQAIVSGNVP SSPEEVEAVW PALAEQLQCC AQNSELSMDS VVPFDAASEV PVEEQRAEAM
VRIQDCLLAG QAPQALTLLR SAREVWPEGD VFGSQDIFPE EEIQLLKQIL SAPLPRQQGP
EERGAEEEEE EEEEEEEEEL QVVQVSEKEF NFLDYLKRFA CSTVVRAYVL LLRSYQQNSA
HTNHCIVKML HRLAHDLKME ALLFQLSVFC LFNRLLSDPA AGAYKELVTF AKYILGKFFA
LAAVNQKAFV ELLFWKNTAV VREMTEGYGS LDDRSSSRRA PTWSPEEEAH LRELYLANKD
VEGQDVVEAI LAHLNTVPRT RKQIIHHLVQ MGLADSVKDF QRKGTHIVLW TGDQELELQR
LFEEFRDSDD VLGHIMKNIT AKRSRARIVD KLLALGLVAE RRELYKKRRK KLASSILPNG
AESLKDFCQE DLEEEENLPE EDSEEEEEGG SEAEQVQGSL VLSNENLGQS LHQEGFSIPL
LWLQNCLIRA ADDREEDGCS QAVPLVPLTE ENEEAMENEQ FQQLLRKLGV RPPASGQETF
WRIPAKLSPT QLRRVAASLS QPEEEQKLQP ELQPKVPGEQ GSDEEHCKEH RAQALRALLL
AHKKKAGLAS PEEEDAVGKE PLKAAPKKRQ LLDSDEEQEE DEGRNRAPEL GAPGIQKKKR
YQIEDDEDD


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