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TIMELESS-interacting protein

 TIPIN_RAT               Reviewed;         276 AA.
Q4QR88;
02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
19-JUL-2005, sequence version 1.
23-MAY-2018, entry version 75.
RecName: Full=TIMELESS-interacting protein;
Name=Tipin;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Thymus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Plays an important role in the control of DNA
replication and the maintenance of replication fork stability.
Important for cell survival after DNA damage or replication
stress. May be specifically required for the ATR-CHEK1 pathway in
the replication checkpoint induced by hydroxyurea or ultraviolet
light. Forms a complex with TIMELESS and this complex regulates
DNA replication processes under both normal and stress conditions,
stabilizes replication forks and influences both CHEK1
phosphorylation and the intra-S phase checkpoint in response to
genotoxic stress.
-!- SUBUNIT: Interacts with TIMELESS, which impairs TIMELESS self-
association. Interacts with RPA2, PRDX2, MCM6 and MCM7 (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}.
-!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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EMBL; BC097351; AAH97351.1; -; mRNA.
RefSeq; NP_001020458.1; NM_001025287.1.
UniGene; Rn.225004; -.
SMR; Q4QR88; -.
STRING; 10116.ENSRNOP00000053083; -.
PaxDb; Q4QR88; -.
GeneID; 363076; -.
KEGG; rno:363076; -.
CTD; 54962; -.
RGD; 1564084; Tipin.
eggNOG; KOG3004; Eukaryota.
eggNOG; ENOG4111VXN; LUCA.
HOGENOM; HOG000154594; -.
HOVERGEN; HBG061130; -.
InParanoid; Q4QR88; -.
KO; K10904; -.
PhylomeDB; Q4QR88; -.
PRO; PR:Q4QR88; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0000790; C:nuclear chromatin; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
GO; GO:0003677; F:DNA binding; IBA:GO_Central.
GO; GO:0044770; P:cell cycle phase transition; ISS:BHF-UCL.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0000076; P:DNA replication checkpoint; ISS:UniProtKB.
GO; GO:0031573; P:intra-S DNA damage checkpoint; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0033262; P:regulation of nuclear cell cycle DNA replication; IBA:GO_Central.
GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
GO; GO:0048478; P:replication fork protection; IBA:GO_Central.
InterPro; IPR012923; Csm3.
Pfam; PF07962; Swi3; 1.
ProDom; PD089639; Swi3; 1.
2: Evidence at transcript level;
Cell cycle; Cell division; Complete proteome; Cytoplasm; DNA damage;
Mitosis; Nucleus; Phosphoprotein; Reference proteome.
CHAIN 1 276 TIMELESS-interacting protein.
/FTId=PRO_0000305255.
REGION 64 140 Interaction with TIMELESS. {ECO:0000250}.
MOD_RES 219 219 Phosphoserine.
{ECO:0000250|UniProtKB:Q9BVW5}.
MOD_RES 233 233 Phosphothreonine.
{ECO:0000250|UniProtKB:Q9BVW5}.
SEQUENCE 276 AA; 31137 MW; 38CCA8E93476B280 CRC64;
MLEQEENGLF EIPDYEHVED ETFPPFPPPG SPERDPAEAE PDEGSGAPVP VPPKRIVKRN
IPKLDATRLT SERGLPALRH VFDKTKFKGK GHEAEDLKTL IRHMEHWAHR LFPKLQFEDF
IDRVENLGNK KEVQTCLKRI RLDLPIVHED FVNNNDEVEE TNSLDAAATG FDAFVTSSSD
SKRFASEASR NLTEEQQQRI EKNKQLALER RQAKLLSNSQ SLENDVTVEE SSTGENQEES
NGLISADGPH DVPSASTQEE GQLEAEETQL DHPNLD


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