GENTAUR Molecular Products.

 A0A2I3RDS7_PANTR        Unreviewed;      1059 AA.
 A0A2I3RDS7; A0A2J8KUI2;
 28-FEB-2018, integrated into UniProtKB/TrEMBL.
 28-FEB-2018, sequence version 1.
 16-JAN-2019, entry version 8.
 SubName: Full=TLR8 isoform 2 {ECO:0000313|EMBL:PNI38658.1};
 Name=TLR8 {ECO:0000313|Ensembl:ENSPTRP00000062546,
 ECO:0000313|VGNC:VGNC:55731};
 ORFNames=CK820_G0035803 {ECO:0000313|EMBL:PNI38658.1};
 Pan troglodytes (Chimpanzee).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
 Catarrhini; Hominidae; Pan.
 NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000062546, ECO:0000313|Proteomes:UP000002277};
 [1] {ECO:0000313|Ensembl:ENSPTRP00000062546, ECO:0000313|Proteomes:UP000002277}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 PubMed=16136131; DOI=10.1038/nature04072;
 Chimpanzee sequencing and analysis consortium;
 "Initial sequence of the chimpanzee genome and comparison with the
 human genome.";
 Nature 437:69-87(2005).
 [2] {ECO:0000313|EMBL:PNI38658.1}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI38658.1};
 TISSUE=Blood {ECO:0000313|EMBL:PNI38658.1};
 Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
 Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
 Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
 Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
 Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
 Haussler D., Eichler E.;
 "High-resolution comparative analysis of great ape genomes.";
 Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
 [3] {ECO:0000313|Ensembl:ENSPTRP00000062546}
 IDENTIFICATION.
 Ensembl;
 Submitted (JAN-2018) to UniProtKB.
 -!- SIMILARITY: Belongs to the Toll-like receptor family.
     {ECO:0000256|SAAS:SAAS00596625}.
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 EMBL; AACZ04014639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 EMBL; NBAG03000336; PNI38658.1; -; Genomic_DNA.
 UniGene; Ptr.6689; -.
 Ensembl; ENSPTRT00000102524; ENSPTRP00000062546; ENSPTRG00000021667.
 VGNC; VGNC:55731; TLR8.
 GeneTree; ENSGT00940000160879; -.
 Proteomes; UP000002277; Chromosome X.
 GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
 GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
 GO; GO:0003677; F:DNA binding; IEA:Ensembl.
 GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
 GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
 GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
 GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
 GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
 GO; GO:0006954; P:inflammatory response; IEA:InterPro.
 GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
 GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl.
 GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
 GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
 GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
 GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
 GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
 GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl.
 GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
 GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
 Gene3D; 3.40.50.10140; -; 1.
 Gene3D; 3.80.10.10; -; 1.
 InterPro; IPR000483; Cys-rich_flank_reg_C.
 InterPro; IPR001611; Leu-rich_rpt.
 InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
 InterPro; IPR032675; LRR_dom_sf.
 InterPro; IPR000157; TIR_dom.
 InterPro; IPR027175; TLR8.
 InterPro; IPR035897; Toll_tir_struct_dom_sf.
 PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1.
 Pfam; PF13855; LRR_8; 5.
 Pfam; PF01582; TIR; 1.
 SMART; SM00369; LRR_TYP; 15.
 SMART; SM00082; LRRCT; 1.
 SMART; SM00255; TIR; 1.
 SUPFAM; SSF52200; SSF52200; 1.
 PROSITE; PS51450; LRR; 20.
 PROSITE; PS50104; TIR; 1.
 3: Inferred from homology;
 Complete proteome {ECO:0000313|Proteomes:UP000002277};
 Immunity {ECO:0000256|SAAS:SAAS00472892};
 Innate immunity {ECO:0000256|SAAS:SAAS00472892};
 Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
 Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
 Receptor {ECO:0000256|SAAS:SAAS00473103};
 Reference proteome {ECO:0000313|Proteomes:UP000002277};
 Repeat {ECO:0000256|SAAS:SAAS00597472};
 Transmembrane {ECO:0000256|SAAS:SAAS00598878,
 ECO:0000256|SAM:Phobius};
 Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
 ECO:0000256|SAM:Phobius}.
 TRANSMEM    844    866       Helical. {ECO:0000256|SAM:Phobius}.
 DOMAIN      896   1043       TIR. {ECO:0000259|PROSITE:PS50104}.
 SEQUENCE   1059 AA;  121694 MW;  8D7CEFE49461CD16 CRC64;
 MKESSLQNSS CSLGKETKKE NMFLQSSMLT CIFLLISGSC ELCAEENFSR SYPCDEKKQN
 DSVIAECSNR RLREVPQTVG KYVTELDLSD NFITHITNES FQGLQNLTKI NLNHNPNVQH
 QNGNPGIQSN GLNITDGAFL NLKNLRELLL EDNQLPQIPS GLPESLTELS LIQNNIYNIT
 KEGISRLINL KNLYLAWNCY FNKVCEKTNI EDGVFETLTN LELLSLSFNS LSHVPPKLPS
 SLRKLFLSNT QIKYISEEDF KGLINLTLLD LSGNCPRCFN APFPCVPCDG GASINIDRFA
 FQNLTQLRYL NLSSTSLRKI NAAWFKNMPH LKVLDLEFNY LVGEIASGAF LTMLPRLEIL
 DLSFNYIKGS YPQHINISKN FSKLLSLRAL HLRGYVFQEL REDDFQPLMQ LPNLSTINLG
 INFIKQIDFK LFQNFSNLEI IYLSENRISP LVKDTRQSYA NSSSFQRHIL KRRSTDFEFD
 PHSNFYHFTR PLIKPQCAAY GKALDLSLNS IFFIGPNQFE NLPDIACLNL SANSNAQVLS
 GTEFSAIPHV KYLDLTNNRL DFDNASALTE LSDLEVLDLS YNSHYFRIAG VTHHLEFIQN
 FTNLKVLNLS HNNIYTLTDK YNLESKSLVE LVFSGNRLDI LWNDDDNRYI SIFKGLKNLT
 RLDLSLNRLK HIPNEAFLNL PASLTELHIN DNMLKFFNWT LLQQFPRLEL LDLRGNKLLF
 LTDSLSDFTS SLRTLLLSHN RISHLPSGFL SEVSSLKHLD LSSNLLKTIN KSALETKTTT
 KLSMLELHGN PFECTCDIGD FRRWMDEHLN VKIPRLVDVI CASPGDQRGK SIVSLELTTC
 VSDVTAVILF FFTFFITTMV MLAALAHHLF YWDVWFIYNV CLAKVKGYRS LSTSQTFYDA
 YISYDTKDAS VTDWVINELR YHLEESRDKN VLLCLEERDW DPGLAIIDNL MQSINQSKKT
 VFVLTKKYAK SWNFKTAFYL ALQRLMDENM DVIIFILLEP VLQHSQYLRL RQRICKSSIL
 QWPDNPKAEG LFWQTLRNVV LTENDSRYNS MYVDSIKQY

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