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TNF receptor associated factor 2

 E1B9D9_BOVIN            Unreviewed;       525 AA.
E1B9D9;
02-NOV-2010, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 2.
25-OCT-2017, entry version 57.
SubName: Full=TNF receptor associated factor 2 {ECO:0000313|Ensembl:ENSBTAP00000013869};
Name=TRAF2 {ECO:0000313|Ensembl:ENSBTAP00000013869};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000013869, ECO:0000313|Proteomes:UP000009136};
[1] {ECO:0000313|Ensembl:ENSBTAP00000013869, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000013869,
ECO:0000313|Proteomes:UP000009136};
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
[2] {ECO:0000313|Ensembl:ENSBTAP00000013869}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000013869};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000013869}.
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EMBL; DAAA02032446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; E1B9D9; -.
IntAct; E1B9D9; 1.
STRING; 9913.ENSBTAP00000013869; -.
PaxDb; E1B9D9; -.
Ensembl; ENSBTAT00000013869; ENSBTAP00000013869; ENSBTAG00000010497.
eggNOG; ENOG410KDGS; Eukaryota.
eggNOG; ENOG410XRXK; LUCA.
GeneTree; ENSGT00550000074359; -.
InParanoid; E1B9D9; -.
OMA; SACRNVL; -.
OrthoDB; EOG091G0GHD; -.
TreeFam; TF321154; -.
Reactome; R-BTA-3371378; Regulation by c-FLIP.
Reactome; R-BTA-5213460; RIPK1-mediated regulated necrosis.
Reactome; R-BTA-5218900; CASP8 activity is inhibited.
Reactome; R-BTA-5357786; TNFR1-induced proapoptotic signaling.
Reactome; R-BTA-5357905; Regulation of TNFR1 signaling.
Reactome; R-BTA-5357956; TNFR1-induced NFkappaB signaling pathway.
Reactome; R-BTA-5668541; TNFR2 non-canonical NF-kB pathway.
Reactome; R-BTA-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
Reactome; R-BTA-5689880; Ub-specific processing proteases.
Reactome; R-BTA-69416; Dimerization of procaspase-8.
Reactome; R-BTA-75893; TNF signaling.
Proteomes; UP000009136; Chromosome 11.
Bgee; ENSBTAG00000010497; -.
GO; GO:1990597; C:AIP1-IRE1 complex; IEA:Ensembl.
GO; GO:0035631; C:CD40 receptor complex; IEA:Ensembl.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:1990604; C:IRE1-TRAF2-ASK1 complex; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0097057; C:TRAF2-GSTP1 complex; IEA:Ensembl.
GO; GO:0000151; C:ubiquitin ligase complex; IEA:Ensembl.
GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO; GO:0005174; F:CD40 receptor binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0046625; F:sphingolipid binding; IEA:Ensembl.
GO; GO:0031996; F:thioesterase binding; IEA:Ensembl.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IEA:Ensembl.
GO; GO:0043623; P:cellular protein complex assembly; IEA:Ensembl.
GO; GO:0071732; P:cellular response to nitric oxide; IEA:Ensembl.
GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1903721; P:positive regulation of I-kappaB phosphorylation; IEA:Ensembl.
GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl.
GO; GO:0043507; P:positive regulation of JUN kinase activity; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0090073; P:positive regulation of protein homodimerization activity; IEA:Ensembl.
GO; GO:0002726; P:positive regulation of T cell cytokine production; IEA:Ensembl.
GO; GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
GO; GO:0097300; P:programmed necrotic cell death; IEA:Ensembl.
GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
GO; GO:0070207; P:protein homotrimerization; IEA:Ensembl.
GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
GO; GO:0051023; P:regulation of immunoglobulin secretion; IEA:Ensembl.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
Gene3D; 2.60.210.10; -; 1.
Gene3D; 3.30.40.10; -; 4.
InterPro; IPR002083; MATH/TRAF_dom.
InterPro; IPR012227; TNF_rcpt--assoc_TRAF.
InterPro; IPR008974; TRAF-like.
InterPro; IPR027133; TRAF2.
InterPro; IPR032070; TRAF_BIRC3-bd.
InterPro; IPR018957; Znf_C3HC4_RING-type.
InterPro; IPR001841; Znf_RING.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
InterPro; IPR017907; Znf_RING_CS.
InterPro; IPR001293; Znf_TRAF.
PANTHER; PTHR10131:SF21; PTHR10131:SF21; 1.
Pfam; PF16673; TRAF_BIRC3_bd; 1.
Pfam; PF00097; zf-C3HC4; 1.
Pfam; PF02176; zf-TRAF; 1.
PIRSF; PIRSF015614; TRAF; 1.
SMART; SM00061; MATH; 1.
SMART; SM00184; RING; 1.
SUPFAM; SSF49599; SSF49599; 1.
PROSITE; PS50144; MATH; 1.
PROSITE; PS00518; ZF_RING_1; 1.
PROSITE; PS50089; ZF_RING_2; 1.
PROSITE; PS50145; ZF_TRAF; 2.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000009136};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00207,
ECO:0000256|SAAS:SAAS00546951};
Reference proteome {ECO:0000313|Proteomes:UP000009136};
Signal {ECO:0000256|SAM:SignalP};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00207,
ECO:0000256|SAAS:SAAS00546951};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00207,
ECO:0000256|SAAS:SAAS00546951}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 525 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003143846.
DOMAIN 43 81 RING-type. {ECO:0000259|PROSITE:PS50089}.
DOMAIN 134 179 TRAF-type. {ECO:0000259|PROSITE:PS50145}.
DOMAIN 186 240 TRAF-type. {ECO:0000259|PROSITE:PS50145}.
DOMAIN 375 520 MATH. {ECO:0000259|PROSITE:PS50144}.
ZN_FING 134 179 TRAF-type. {ECO:0000256|PROSITE-
ProRule:PRU00207}.
ZN_FING 186 240 TRAF-type. {ECO:0000256|PROSITE-
ProRule:PRU00207}.
SEQUENCE 525 AA; 58275 MW; 8A39033B551BAA6A CRC64;
AWAWWAAALM AAASVTPPGS LDLLQPGFSK TLLGTKLEDK YLCSACKNVL RRPFQAQCGH
RYCSFCLSSI LSSGPQSCAA CVHEGIYEEG VSILESSSAF PDNAARREVE SLPAVCPSEG
CSWKGTLKDY ESCHEGQCPF MLTECPACKG LVRLGEKEHH LEHQCPERSL SCRHCRAPCS
PADMKAHHQI CPKFPLTCDG CGKKKIAREK FQDHVRACGR CRVPCRFHAV GCPEMVESEQ
QPEHEAQRLQ EHLALLLGVL LEAGRPPGDS RLLLRPGEGA LEAGTPSRVA ELLQRCEALE
RKTATFENIV CVLNREVERV AVTAEACGRQ HRLDQDRIEA LSNKVQQLER SIGLKDLAMA
DLEQKVLEME ASTFDGVFIW KISDFSRKRQ EAVAGRTPAI FSPAFYTSRY GYKMCLRAYL
NGDGTGRGTH LSLFFVLMRG PHDALLRWPF NQKVTLMLLD QNNREHVIDA FRPDVTSSSF
QRPVGDMNIA SGCPLFCPVS KMEAKNSYVR DDAIFIKAIV DLTGL


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