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TNF receptor-associated factor 2

 F7F4I2_CALJA            Unreviewed;       501 AA.
F7F4I2;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
25-OCT-2017, entry version 48.
SubName: Full=TNF receptor-associated factor 2 {ECO:0000313|EMBL:JAB06058.1, ECO:0000313|Ensembl:ENSCJAP00000020621};
Name=TRAF2 {ECO:0000313|EMBL:JAB06058.1,
ECO:0000313|Ensembl:ENSCJAP00000020621};
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000020621, ECO:0000313|Proteomes:UP000008225};
[1] {ECO:0000313|Ensembl:ENSCJAP00000020621, ECO:0000313|Proteomes:UP000008225}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCJAP00000020621}
IDENTIFICATION.
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[3] {ECO:0000313|EMBL:JAB06058.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Bladder {ECO:0000313|EMBL:JAB06058.1},
Cerebellum {ECO:0000313|EMBL:JAB48792.1},
Cerebral cortex {ECO:0000313|EMBL:JAB25447.1},
Hippocampus {ECO:0000313|EMBL:JAB15854.1}, and
Skeletal muscle {ECO:0000313|EMBL:JAB34685.1};
PubMed=25243066; DOI=10.1186/2047-217X-3-14;
Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
Moriyama E.N., French J.A., Norgren R.B.Jr.;
"De novo assembly of the common marmoset transcriptome from NextGen
mRNA sequences.";
Gigascience 3:14-14(2014).
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EMBL; ACFV01116592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01116593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01116594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01116595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01116596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01116597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01116598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GAMT01005803; JAB06058.1; -; mRNA.
EMBL; GAMS01007282; JAB15854.1; -; mRNA.
EMBL; GAMR01008485; JAB25447.1; -; mRNA.
EMBL; GAMQ01007166; JAB34685.1; -; mRNA.
EMBL; GAMP01003963; JAB48792.1; -; mRNA.
RefSeq; XP_003732128.1; XM_003732080.3.
RefSeq; XP_009003932.1; XM_009005684.2.
RefSeq; XP_009003958.1; XM_009005710.2.
RefSeq; XP_009003966.1; XM_009005718.2.
STRING; 9483.ENSCJAP00000020621; -.
Ensembl; ENSCJAT00000021795; ENSCJAP00000020621; ENSCJAG00000011179.
Ensembl; ENSCJAT00000059302; ENSCJAP00000051347; ENSCJAG00000011179.
GeneID; 100404226; -.
KEGG; cjc:100404226; -.
CTD; 7186; -.
eggNOG; ENOG410ISDM; Eukaryota.
eggNOG; ENOG4111M70; LUCA.
GeneTree; ENSGT00550000074359; -.
KO; K03173; -.
OrthoDB; EOG091G0GHD; -.
TreeFam; TF321154; -.
Proteomes; UP000008225; Chromosome 1.
GO; GO:1990597; C:AIP1-IRE1 complex; IEA:Ensembl.
GO; GO:0035631; C:CD40 receptor complex; IEA:Ensembl.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:1990604; C:IRE1-TRAF2-ASK1 complex; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0097057; C:TRAF2-GSTP1 complex; IEA:Ensembl.
GO; GO:0000151; C:ubiquitin ligase complex; IEA:Ensembl.
GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO; GO:0005174; F:CD40 receptor binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0046625; F:sphingolipid binding; IEA:Ensembl.
GO; GO:0031996; F:thioesterase binding; IEA:Ensembl.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IEA:Ensembl.
GO; GO:0043623; P:cellular protein complex assembly; IEA:Ensembl.
GO; GO:0071732; P:cellular response to nitric oxide; IEA:Ensembl.
GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1903721; P:positive regulation of I-kappaB phosphorylation; IEA:Ensembl.
GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl.
GO; GO:0043507; P:positive regulation of JUN kinase activity; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0090073; P:positive regulation of protein homodimerization activity; IEA:Ensembl.
GO; GO:0002726; P:positive regulation of T cell cytokine production; IEA:Ensembl.
GO; GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
GO; GO:0097300; P:programmed necrotic cell death; IEA:Ensembl.
GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
GO; GO:0070207; P:protein homotrimerization; IEA:Ensembl.
GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
GO; GO:0051023; P:regulation of immunoglobulin secretion; IEA:Ensembl.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
Gene3D; 2.60.210.10; -; 1.
Gene3D; 3.30.40.10; -; 4.
InterPro; IPR002083; MATH/TRAF_dom.
InterPro; IPR012227; TNF_rcpt--assoc_TRAF.
InterPro; IPR008974; TRAF-like.
InterPro; IPR027133; TRAF2.
InterPro; IPR032070; TRAF_BIRC3-bd.
InterPro; IPR018957; Znf_C3HC4_RING-type.
InterPro; IPR001841; Znf_RING.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
InterPro; IPR017907; Znf_RING_CS.
InterPro; IPR001293; Znf_TRAF.
PANTHER; PTHR10131:SF21; PTHR10131:SF21; 1.
Pfam; PF16673; TRAF_BIRC3_bd; 1.
Pfam; PF00097; zf-C3HC4; 1.
Pfam; PF02176; zf-TRAF; 1.
PIRSF; PIRSF015614; TRAF; 1.
SMART; SM00061; MATH; 1.
SMART; SM00184; RING; 1.
SUPFAM; SSF49599; SSF49599; 1.
PROSITE; PS50144; MATH; 1.
PROSITE; PS00518; ZF_RING_1; 1.
PROSITE; PS50089; ZF_RING_2; 1.
PROSITE; PS50145; ZF_TRAF; 2.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000008225};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00207,
ECO:0000256|SAAS:SAAS00546951};
Receptor {ECO:0000313|EMBL:JAB06058.1};
Reference proteome {ECO:0000313|Proteomes:UP000008225};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00207,
ECO:0000256|SAAS:SAAS00546951};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00207,
ECO:0000256|SAAS:SAAS00546951}.
DOMAIN 34 72 RING-type. {ECO:0000259|PROSITE:PS50089}.
DOMAIN 125 170 TRAF-type. {ECO:0000259|PROSITE:PS50145}.
DOMAIN 177 233 TRAF-type. {ECO:0000259|PROSITE:PS50145}.
DOMAIN 351 496 MATH. {ECO:0000259|PROSITE:PS50144}.
ZN_FING 125 170 TRAF-type. {ECO:0000256|PROSITE-
ProRule:PRU00207}.
ZN_FING 177 233 TRAF-type. {ECO:0000256|PROSITE-
ProRule:PRU00207}.
SEQUENCE 501 AA; 55906 MW; 7BF1EF7A4C3D051A CRC64;
MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS
ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE
YESCHEGRCP LMLTECPACK GLVRLGDKER HLEHECPERS LSCRHCRAPC CGADVKAHHE
VCPKFPLTCD GCGKKKIPRE KFQDHIKTCG KCRVPCRFHA LGCLETVEGE KQQEHEAQWL
REHLAMLLSS VLETKPLSGD QSQVGSELLQ RCETLEKKTA TFENIVCVLN REVERVALTV
EACSRQHRLD LDRIEALSNK VQQLERSIGL KDLAMADLEQ KVLEMEASTY DGVFIWKISD
FARKRQEAVA GRTPAIFSPA FYTSRYGYKM CLRIYLNGDG TGRGTHLSLF FVVMKGPNDA
LLRWPFNQKV TLMLLDQNNR EHVIDAFRPD VTSSSFQRPV NDMNIASGCP LFCPVSKMEA
KNSYVRDDAI FIKAIVDLTG L


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