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TNF superfamily member 12 (Tumor necrosis factor superfamily member 12) (Zgc:153941)

 Q08BZ0_DANRE            Unreviewed;       236 AA.
Q08BZ0;
31-OCT-2006, integrated into UniProtKB/TrEMBL.
31-OCT-2006, sequence version 1.
28-MAR-2018, entry version 82.
SubName: Full=TNF superfamily member 12 {ECO:0000313|Ensembl:ENSDARP00000091671};
SubName: Full=Tumor necrosis factor superfamily member 12 {ECO:0000313|EMBL:ADM64322.1};
SubName: Full=Zgc:153941 {ECO:0000313|EMBL:AAI24496.1};
Name=tnfsf12 {ECO:0000313|Ensembl:ENSDARP00000091671,
ECO:0000313|ZFIN:ZDB-GENE-060929-376};
ORFNames=zgc:153941 {ECO:0000313|EMBL:AAI54256.1};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI24496.1};
[1] {ECO:0000313|EMBL:AAI54256.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Whole {ECO:0000313|EMBL:AAI54256.1};
PubMed=12477932; DOI=10.1073/pnas.242603899;
Mammalian Gene Collection Program Team;
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD,
Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B,
Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T,
Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA,
Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL,
Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P,
Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ,
Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S,
Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM,
Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A,
Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y,
Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC,
Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS,
Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE,
Jones SJ Marra.MA.;
"Generation and initial analysis of more than 15,000 full-length human
and mouse cDNA sequences.";
Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
[2] {ECO:0000313|EMBL:AAI24496.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Whole {ECO:0000313|EMBL:AAI24496.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:AAI54256.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Whole {ECO:0000313|EMBL:AAI54256.1};
NIH MGC Project;
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:ADM64322.1}
NUCLEOTIDE SEQUENCE.
Du M.-X., Shen Y.-F., Zhang J.-X., Xu X.-Z., Cui X.-W., Zhang S.-Q.;
"Molecular cloning and phylogenetic analysis of tweak in zebrafish
(Danio rerio).";
Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:ADM64322.1}
NUCLEOTIDE SEQUENCE.
PubMed=22161014; DOI=10.1007/s10528-011-9482-0;
Du M., Liang Z., Xu X., Li J., Ai H., Zhang J., Zhang S.;
"Molecular Cloning, Phylogenetic Analysis, Tissue Distribution, and
Expression of the Cytokine TWEAK in Zebrafish (Danio rerio).";
Biochem. Genet. 50:318-324(2012).
[6] {ECO:0000313|Ensembl:ENSDARP00000091671}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000091671};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[7] {ECO:0000313|Ensembl:ENSDARP00000091671, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000091671,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
Saunders D., Wallis J., Babbage A., Hammond S.,
Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
-!- SIMILARITY: Belongs to the tumor necrosis factor family.
{ECO:0000256|SAAS:SAAS00758062}.
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EMBL; CR318653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC124495; AAI24496.1; -; mRNA.
EMBL; BC154255; AAI54256.1; -; mRNA.
EMBL; HM439092; ADM64322.1; -; mRNA.
RefSeq; NP_001070075.1; NM_001076607.1.
UniGene; Dr.88400; -.
STRING; 7955.ENSDARP00000091671; -.
Ensembl; ENSDART00000100898; ENSDARP00000091671; ENSDARG00000069376.
GeneID; 567542; -.
KEGG; dre:567542; -.
CTD; 8742; -.
ZFIN; ZDB-GENE-060929-376; tnfsf12.
eggNOG; ENOG410IWIA; Eukaryota.
eggNOG; ENOG410YP8Z; LUCA.
GeneTree; ENSGT00510000050706; -.
HOGENOM; HOG000118354; -.
HOVERGEN; HBG096254; -.
KO; K05474; -.
OMA; TAWTWRQ; -.
OrthoDB; EOG091G0MIB; -.
TreeFam; TF332331; -.
Proteomes; UP000000437; Chromosome 7.
Bgee; ENSDARG00000069376; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
GO; GO:0006955; P:immune response; IEA:InterPro.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR006052; TNF_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
Pfam; PF00229; TNF; 1.
SMART; SM00207; TNF; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS50049; TNF_2; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000000437};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000000437};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 12 37 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 97 235 TNF_2. {ECO:0000259|PROSITE:PS50049}.
SEQUENCE 236 AA; 27149 MW; A406A624533EF199 CRC64;
MQRIFQRRRI RTLRWVWSLM AVLALSLAVC SAIFTVWTLR QTRDLSRSFQ TLQERLEQVN
MQRKAIFQLI LEKRELLESQ RFRRDVGGKK GNGRKVASHF EITSDSFQKV GNEGVIKGWT
EEQLNMSRAV NYNSETGTFR VERSGVYFVY CQVHFNENQS QYVKLEVSIP KGPLLQCIEG
YGTTPASGSH RFHFLKPCQV SGLLRLNKGT ELKAVTGASF SLQTSGKHYF GLFKVN


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