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TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (DIP protein) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein)

 T22D3_PIG               Reviewed;          77 AA.
P80220;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
05-JUL-2017, entry version 112.
RecName: Full=TSC22 domain family protein 3;
AltName: Full=DSIP-immunoreactive peptide;
Short=DIP protein;
AltName: Full=Delta sleep-inducing peptide immunoreactor;
AltName: Full=Glucocorticoid-induced leucine zipper protein;
Name=TSC22D3; Synonyms=DSIPI, GILZ;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
PROTEIN SEQUENCE, AND ACETYLATION AT MET-1.
TISSUE=Brain;
PubMed=8375381; DOI=10.1111/j.1432-1033.1993.tb18160.x;
Sillard R., Schulz-Knappe P., Vogel P., Raida M., Bensch K.W.,
Forssmann W.-G., Mutt M.;
"A novel 77-residue peptide from porcine brain contains a leucine-
zipper motif and is recognized by an antiserum to delta-sleep-inducing
peptide.";
Eur. J. Biochem. 216:429-436(1993).
[2]
STRUCTURE BY NMR.
PubMed=9388238; DOI=10.1074/jbc.272.49.30918;
Seidel G., Adermann K., Schindler T., Ejchart A., Jaenicke R.,
Forssmann W.-G., Roesch P.;
"Solution structure of porcine delta sleep-inducing peptide
immunoreactive peptide A homolog of the shortsighted gene product.";
J. Biol. Chem. 272:30918-30927(1997).
-!- FUNCTION: Protects T-cells from IL2 deprivation-induced apoptosis
through the inhibition of FOXO3A transcriptional activity that
leads to the down-regulation of the pro-apoptotic factor BCL2L11.
In macrophages, plays a role in the anti-inflammatory and
immunosuppressive effects of glucocorticoids and IL10. In T-cells,
inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro,
suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic
differentiation and mediates anti-myogenic effects of
glucocorticoids by binding and regulating MYOD1 and HDAC1
transcriptional activity resulting in reduced expression of MYOG
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Can form homodimers, however it is likely to function as
a monomer. Interacts with AP1 and NFKB1. Interacts with MYOD1.
Interacts with HDAC1; this interaction affects HDAC1 activity on
MYOG promoter and thus inhibits MYOD1 transcriptional activity (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}. Note=Localization depends on differentiation status
of myoblasts. In undifferentiated myoblasts, localizes to the
cytoplasm, but in differentiating myoblasts is localized to the
nucleus (By similarity). {ECO:0000250}.
-!- INDUCTION: By glucocorticoids in lymphoid cells and upon IL4,
IL10, IL13 or glucocorticoid treatment in monocyte/macrophage
cells. Transiently induced by IL2 deprivation in T-cells.
Expression is up-regulated by synthetic glucocorticoid
dexamethasone in differentiating myoblasts (By similarity).
{ECO:0000250}.
-!- DOMAIN: The leucine-zipper is involved in homodimerization.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family. {ECO:0000305}.
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PIR; S36827; S36827.
UniGene; Ssc.2682; -.
UniGene; Ssc.57721; -.
PDB; 1DIP; NMR; -; A/B=1-77.
PDBsum; 1DIP; -.
DisProt; DP00759; -.
ProteinModelPortal; P80220; -.
SMR; P80220; -.
PaxDb; P80220; -.
PeptideAtlas; P80220; -.
Ensembl; ENSSSCT00000031772; ENSSSCP00000021368; ENSSSCG00000030241.
eggNOG; KOG4797; Eukaryota.
eggNOG; ENOG411251N; LUCA.
GeneTree; ENSGT00530000063062; -.
HOGENOM; HOG000015349; -.
HOVERGEN; HBG075918; -.
InParanoid; P80220; -.
OMA; RRHIFRI; -.
OrthoDB; EOG091G06PM; -.
Reactome; R-SSC-2672351; Stimuli-sensing channels.
EvolutionaryTrace; P80220; -.
Proteomes; UP000008227; Chromosome X.
Bgee; ENSSSCG00000030241; -.
Genevisible; P80220; SS.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0070236; P:negative regulation of activation-induced cell death of T cells; IBA:GO_Central.
InterPro; IPR000580; TSC-22_Dip_Bun.
PANTHER; PTHR12348; PTHR12348; 1.
Pfam; PF01166; TSC22; 1.
ProDom; PD007152; TSC-22_Dip_Bun; 1.
PROSITE; PS01289; TSC22; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Complete proteome; Cytoplasm;
Direct protein sequencing; Nucleus; Phosphoprotein;
Reference proteome.
CHAIN 1 77 TSC22 domain family protein 3.
/FTId=PRO_0000219372.
REGION 19 40 Leucine-zipper.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000269|PubMed:8375381}.
MOD_RES 45 45 Phosphoserine.
{ECO:0000250|UniProtKB:Q99576}.
TURN 4 6 {ECO:0000244|PDB:1DIP}.
HELIX 7 10 {ECO:0000244|PDB:1DIP}.
HELIX 17 43 {ECO:0000244|PDB:1DIP}.
STRAND 45 47 {ECO:0000244|PDB:1DIP}.
STRAND 53 56 {ECO:0000244|PDB:1DIP}.
STRAND 62 64 {ECO:0000244|PDB:1DIP}.
SEQUENCE 77 AA; 8713 MW; A46C9FC08B72542D CRC64;
MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSRLSPEE
PAPETPEAPE APGGSAV


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