Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (DIP protein) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein)

 T22D3_PIG               Reviewed;          77 AA.
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
05-JUL-2017, entry version 112.
RecName: Full=TSC22 domain family protein 3;
AltName: Full=DSIP-immunoreactive peptide;
Short=DIP protein;
AltName: Full=Delta sleep-inducing peptide immunoreactor;
AltName: Full=Glucocorticoid-induced leucine zipper protein;
Name=TSC22D3; Synonyms=DSIPI, GILZ;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
PubMed=8375381; DOI=10.1111/j.1432-1033.1993.tb18160.x;
Sillard R., Schulz-Knappe P., Vogel P., Raida M., Bensch K.W.,
Forssmann W.-G., Mutt M.;
"A novel 77-residue peptide from porcine brain contains a leucine-
zipper motif and is recognized by an antiserum to delta-sleep-inducing
Eur. J. Biochem. 216:429-436(1993).
PubMed=9388238; DOI=10.1074/jbc.272.49.30918;
Seidel G., Adermann K., Schindler T., Ejchart A., Jaenicke R.,
Forssmann W.-G., Roesch P.;
"Solution structure of porcine delta sleep-inducing peptide
immunoreactive peptide A homolog of the shortsighted gene product.";
J. Biol. Chem. 272:30918-30927(1997).
-!- FUNCTION: Protects T-cells from IL2 deprivation-induced apoptosis
through the inhibition of FOXO3A transcriptional activity that
leads to the down-regulation of the pro-apoptotic factor BCL2L11.
In macrophages, plays a role in the anti-inflammatory and
immunosuppressive effects of glucocorticoids and IL10. In T-cells,
inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro,
suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic
differentiation and mediates anti-myogenic effects of
glucocorticoids by binding and regulating MYOD1 and HDAC1
transcriptional activity resulting in reduced expression of MYOG
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Can form homodimers, however it is likely to function as
a monomer. Interacts with AP1 and NFKB1. Interacts with MYOD1.
Interacts with HDAC1; this interaction affects HDAC1 activity on
MYOG promoter and thus inhibits MYOD1 transcriptional activity (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}. Note=Localization depends on differentiation status
of myoblasts. In undifferentiated myoblasts, localizes to the
cytoplasm, but in differentiating myoblasts is localized to the
nucleus (By similarity). {ECO:0000250}.
-!- INDUCTION: By glucocorticoids in lymphoid cells and upon IL4,
IL10, IL13 or glucocorticoid treatment in monocyte/macrophage
cells. Transiently induced by IL2 deprivation in T-cells.
Expression is up-regulated by synthetic glucocorticoid
dexamethasone in differentiating myoblasts (By similarity).
-!- DOMAIN: The leucine-zipper is involved in homodimerization.
-!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
PIR; S36827; S36827.
UniGene; Ssc.2682; -.
UniGene; Ssc.57721; -.
PDB; 1DIP; NMR; -; A/B=1-77.
PDBsum; 1DIP; -.
DisProt; DP00759; -.
ProteinModelPortal; P80220; -.
SMR; P80220; -.
PaxDb; P80220; -.
PeptideAtlas; P80220; -.
Ensembl; ENSSSCT00000031772; ENSSSCP00000021368; ENSSSCG00000030241.
eggNOG; KOG4797; Eukaryota.
eggNOG; ENOG411251N; LUCA.
GeneTree; ENSGT00530000063062; -.
HOGENOM; HOG000015349; -.
HOVERGEN; HBG075918; -.
InParanoid; P80220; -.
OrthoDB; EOG091G06PM; -.
Reactome; R-SSC-2672351; Stimuli-sensing channels.
EvolutionaryTrace; P80220; -.
Proteomes; UP000008227; Chromosome X.
Bgee; ENSSSCG00000030241; -.
Genevisible; P80220; SS.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0070236; P:negative regulation of activation-induced cell death of T cells; IBA:GO_Central.
InterPro; IPR000580; TSC-22_Dip_Bun.
PANTHER; PTHR12348; PTHR12348; 1.
Pfam; PF01166; TSC22; 1.
ProDom; PD007152; TSC-22_Dip_Bun; 1.
PROSITE; PS01289; TSC22; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Complete proteome; Cytoplasm;
Direct protein sequencing; Nucleus; Phosphoprotein;
Reference proteome.
CHAIN 1 77 TSC22 domain family protein 3.
REGION 19 40 Leucine-zipper.
MOD_RES 1 1 N-acetylmethionine.
MOD_RES 45 45 Phosphoserine.
TURN 4 6 {ECO:0000244|PDB:1DIP}.
HELIX 7 10 {ECO:0000244|PDB:1DIP}.
HELIX 17 43 {ECO:0000244|PDB:1DIP}.
STRAND 45 47 {ECO:0000244|PDB:1DIP}.
STRAND 53 56 {ECO:0000244|PDB:1DIP}.
STRAND 62 64 {ECO:0000244|PDB:1DIP}.
SEQUENCE 77 AA; 8713 MW; A46C9FC08B72542D CRC64;

Related products :

Catalog number Product name Quantity
EIAAB41081 Delta sleep-inducing peptide immunoreactor,DIP protein,DSIPI,DSIP-immunoreactive peptide,GILZ,Glucocorticoid-induced leucine zipper protein,Pig,Sus scrofa,TSC22 domain family protein 3,TSC22D3
EIAAB41082 Delta sleep-inducing peptide immunoreactor,DSIPI,DSIP-immunoreactive peptide,GILZ,GILZ,Glucocorticoid-induced leucine zipper protein,hDIP,Homo sapiens,Human,Protein DIP,TSC22 domain family protein 3,T
EIAAB41080 Dsip1,Dsipi,Gilz,Glucocorticoid-induced leucine zipper protein,Mouse,Mus musculus,Tilz3,TSC22 domain family protein 3,Tsc22d3,TSC22-related-inducible leucine zipper 3
EIAAB41083 Dsipi,Gilz,Glucocorticoid-induced leucine zipper protein,Rat,Rattus norvegicus,TSC22 domain family protein 3,Tsc22d3
EIAAB41084 Homo sapiens,Human,TILZ2,TSC22 domain family protein 4,TSC22D4,Tsc-22-like protein THG-1,TSC22-related-inducible leucine zipper protein 2
18-003-42021 TSC22 domain family protein 4 - TSC22-related-inducible leucine zipper protein 2; Tsc-22-like protein THG-1 Polyclonal 0.1 mg Protein A
18-003-43359 TSC22 domain family protein 2 - TSC22-related-inducible leucine zipper protein 4 Polyclonal 0.05 mg Aff Pur
18-003-43856 TSC22 domain family protein 2 - TSC22-related-inducible leucine zipper protein 4 Polyclonal 0.1 mg Protein A
18-003-44111 TSC22 domain family protein 2 - TSC22-related-inducible leucine zipper protein 4 Polyclonal 0.05 mg Aff Pur
EIAAB41085 Mouse,Mus musculus,Tilz2,TSC22 domain family protein 4,Tsc22d4,TSC22-related-inducible leucine zipper protein 2
EIAAB41079 Homo sapiens,Human,KIAA0669,TILZ4,TSC22 domain family protein 2,TSC22D2,TSC22-related-inducible leucine zipper protein 4
DL-dSIP-Hu Human Delta-Sleep Inducing Peptide (dSIP) ELISA Kit 96T
D-0201-3 (β-Asp5)-Delta-Sleep Inducing Peptide (β-Asp5)-Delta-Sleep Inducing Peptide (rabbit), (β-Asp5)-DSIP (rabbit) 98 percent C35H48N10O15 CAS: 82602-88-8 5mg
D-0201-2 (Asn5)-Delta-Sleep Inducing Peptide (Asn5)-Delta-Sleep Inducing Peptide (rabbit), (Asn5)-DSIP (rabbit) 98 percent C35H49N11O14 CAS: 80064-67-1 5mg
UCBVB500 Delta Sleep Inducing Peptide (DSIP) 5 mg.
06-271-83185 Delta Sleep Inducing Peptide - DSIP 1 mg
D-0201-4 (Tyr1)-Delta-Sleep Inducing Peptide (Tyr1)-Delta-Sleep Inducing Peptide (rabbit), (Tyr1)-DSIP (rabbit) 98 percent C33H47N9O16 CAS: 5mg
E02D0058 Rat Delta Sleep Inducing Peptide Elisa Kit (dSIP) 96 Tests/kit
E02D0058 Rat Delta Sleep-Inducing Peptide ELISA , dSIP 96 Tests/kit
E90708Hu ELISA Kit for Delta Sleep Inducing Peptide (dSIP) 96T/Kit
E02D0058 Rat Delta Sleep-Inducing Peptide ELISA , dSIP
E12410725 Rat delta sleep-inducing peptide(DSIP) ELISA KIT 1
201-12-1307 Human delta sleep-inducing peptide,DSIP ELISA Kit 48T
E14D0058 Sheep Delta Sleep-Inducing Peptide ELISA , dSIP
E06D0058 Goat Delta Sleep-Inducing Peptide ELISA , dSIP 96 Tests/kit


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur

Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017


france@gentaur.com | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur