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Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2)

 TS1R2_MOUSE             Reviewed;         843 AA.
Q925I4; B1AXX0; Q923J8;
04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
07-JUN-2017, entry version 122.
RecName: Full=Taste receptor type 1 member 2;
AltName: Full=G-protein coupled receptor 71;
AltName: Full=Sweet taste receptor T1R2;
Flags: Precursor;
Name=Tas1r2; Synonyms=Gpr71, T1r2, Tr2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS GLY-350
AND ARG-352.
STRAIN=C57BL/6J, and DBA/2J;
PubMed=11319557; DOI=10.1038/87440;
Montmayeur J.-P., Liberles S.D., Matsunami H., Buck L.B.;
"A candidate taste receptor gene near a sweet taste locus.";
Nat. Neurosci. 4:492-498(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11509186; DOI=10.1016/S0092-8674(01)00451-2;
Nelson G., Hoon M.A., Chandrashekar J., Zhang Y., Ryba N.J.P.,
Zuker C.S.;
"Mammalian sweet taste receptors.";
Cell 106:381-390(2001).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
PubMed=12892531; DOI=10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2;
Ariyasu T., Matsumoto S., Kyono F., Hanaya T., Arai S., Ikeda M.,
Kurimoto M.;
"Taste receptor T1R3 is an essential molecule for the cellular
recognition of the disaccharide trehalose.";
In Vitro Cell. Dev. Biol. Anim. 39:80-88(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
-!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes
diverse natural and synthetic sweeteners.
-!- SUBUNIT: Forms heterodimers with TAS1R3.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed mainly in circumvallate and foliate
taste papillae. {ECO:0000269|PubMed:11319557}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
TAS1R subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF337041; AAK39438.1; -; mRNA.
EMBL; AY032623; AAK51604.1; -; mRNA.
EMBL; AL831790; CAM21312.1; -; Genomic_DNA.
CCDS; CCDS18849.1; -.
RefSeq; NP_114079.1; NM_031873.1.
UniGene; Mm.190612; -.
ProteinModelPortal; Q925I4; -.
SMR; Q925I4; -.
IntAct; Q925I4; 1.
STRING; 10090.ENSMUSP00000030510; -.
PhosphoSitePlus; Q925I4; -.
PaxDb; Q925I4; -.
PRIDE; Q925I4; -.
Ensembl; ENSMUST00000030510; ENSMUSP00000030510; ENSMUSG00000028738.
GeneID; 83770; -.
KEGG; mmu:83770; -.
UCSC; uc008vmr.1; mouse.
CTD; 80834; -.
MGI; MGI:1933546; Tas1r2.
eggNOG; KOG1056; Eukaryota.
eggNOG; ENOG410XR6W; LUCA.
GeneTree; ENSGT00760000118884; -.
HOGENOM; HOG000038047; -.
HOVERGEN; HBG108601; -.
InParanoid; Q925I4; -.
KO; K04625; -.
OMA; FITLSMT; -.
OrthoDB; EOG091G035J; -.
PhylomeDB; Q925I4; -.
TreeFam; TF331269; -.
Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
ChiTaRS; Tas1r2; mouse.
PRO; PR:Q925I4; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000028738; -.
CleanEx; MM_TAS1R2; -.
ExpressionAtlas; Q925I4; baseline and differential.
Genevisible; Q925I4; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0043235; C:receptor complex; ISO:MGI.
GO; GO:1903767; C:sweet taste receptor complex; ISO:MGI.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0033041; F:sweet taste receptor activity; IEA:Ensembl.
GO; GO:0008527; F:taste receptor activity; ISO:MGI.
GO; GO:0001582; P:detection of chemical stimulus involved in sensory perception of sweet taste; ISO:MGI.
GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
GO; GO:0050916; P:sensory perception of sweet taste; IGI:MGI.
InterPro; IPR001828; ANF_lig-bd_rcpt.
InterPro; IPR000337; GPCR_3.
InterPro; IPR011500; GPCR_3_9-Cys_dom.
InterPro; IPR017978; GPCR_3_C.
InterPro; IPR017979; GPCR_3_CS.
InterPro; IPR028082; Peripla_BP_I.
Pfam; PF00003; 7tm_3; 1.
Pfam; PF01094; ANF_receptor; 1.
Pfam; PF07562; NCD3G; 1.
PRINTS; PR00248; GPCRMGR.
SUPFAM; SSF53822; SSF53822; 1.
PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; G-protein coupled receptor;
Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome;
Sensory transduction; Signal; Taste; Transducer; Transmembrane;
Transmembrane helix.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 843 Taste receptor type 1 member 2.
/FTId=PRO_0000012958.
TOPO_DOM 20 570 Extracellular. {ECO:0000255}.
TRANSMEM 571 591 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 592 606 Cytoplasmic. {ECO:0000255}.
TRANSMEM 607 627 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 628 642 Extracellular. {ECO:0000255}.
TRANSMEM 643 663 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 664 682 Cytoplasmic. {ECO:0000255}.
TRANSMEM 683 703 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 704 731 Extracellular. {ECO:0000255}.
TRANSMEM 732 752 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 753 764 Cytoplasmic. {ECO:0000255}.
TRANSMEM 765 785 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 786 789 Extracellular. {ECO:0000255}.
TRANSMEM 790 810 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 811 843 Cytoplasmic. {ECO:0000255}.
CARBOHYD 87 87 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 296 296 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 316 316 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 355 355 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 372 372 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 432 432 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 484 484 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 491 491 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 531 531 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 350 350 E -> G (in strain: DBA/2J).
{ECO:0000269|PubMed:11319557}.
VARIANT 352 352 P -> R (in strain: DBA/2J).
{ECO:0000269|PubMed:11319557}.
CONFLICT 175 175 R -> Q (in Ref. 2; AAK51604).
{ECO:0000305}.
CONFLICT 527 527 G -> D (in Ref. 2; AAK51604).
{ECO:0000305}.
CONFLICT 695 695 A -> V (in Ref. 3). {ECO:0000305}.
CONFLICT 701 701 M -> T (in Ref. 3). {ECO:0000305}.
SEQUENCE 843 AA; 95736 MW; 0543834EA4E7AC2E CRC64;
MGPQARTLHL LFLLLHALPK PVMLVGNSDF HLAGDYLLGG LFTLHANVKS VSHLSYLQVP
KCNEYNMKVL GYNLMQAMRF AVEEINNCSS LLPGVLLGYE MVDVCYLSNN IQPGLYFLSQ
IDDFLPILKD YSQYRPQVVA VIGPDNSESA ITVSNILSYF LVPQVTYSAI TDKLRDKRRF
PAMLRTVPSA THHIEAMVQL MVHFQWNWIV VLVSDDDYGR ENSHLLSQRL TNTGDICIAF
QEVLPVPEPN QAVRPEEQDQ LDNILDKLRR TSARVVVIFS PELSLHNFFR EVLRWNFTGF
VWIASESWAI DPVLHNLTEL RHTGTFLGVT IQRVSIPGFS QFRVRHDKPE YPMPNETSLR
TTCNQDCDAC MNITESFNNV LMLSGERVVY SVYSAVYAVA HTLHRLLHCN QVRCTKQIVY
PWQLLREIWH VNFTLLGNQL FFDEQGDMPM LLDIIQWQWG LSQNPFQSIA SYSPTETRLT
YISNVSWYTP NNTVPISMCS KSCQPGQMKK PIGLHPCCFE CVDCPPGTYL NRSVDEFNCL
SCPGSMWSYK NNIACFKRRL AFLEWHEVPT IVVTILAALG FISTLAILLI FWRHFQTPMV
RSAGGPMCFL MLVPLLLAFG MVPVYVGPPT VFSCFCRQAF FTVCFSVCLS CITVRSFQIV
CVFKMARRLP SAYGFWMRYH GPYVFVAFIT AVKVALVAGN MLATTINPIG RTDPDDPNII
ILSCHPNYRN GLLFNTSMDL LLSVLGFSFA YVGKELPTNY NEAKFITLSM TFSFTSSISL
CTFMSVHDGV LVTIMDLLVT VLNFLAIGLG YFGPKCYMIL FYPERNTSAY FNSMIQGYTM
RKS


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