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Taste receptor type 2 member 10 (T2R10) (Taste receptor family B member 2) (TRB2)

 T2R10_HUMAN             Reviewed;         307 AA.
Q9NYW0; Q3MIM9; Q6NTD9;
11-APR-2003, integrated into UniProtKB/Swiss-Prot.
02-NOV-2010, sequence version 3.
27-SEP-2017, entry version 123.
RecName: Full=Taste receptor type 2 member 10;
Short=T2R10;
AltName: Full=Taste receptor family B member 2;
Short=TRB2;
Name=TAS2R10;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY.
PubMed=10761934; DOI=10.1016/S0092-8674(00)80705-9;
Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
Zuker C.S.;
"A novel family of mammalian taste receptors.";
Cell 100:693-702(2000).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT MET-156.
PubMed=15496549; DOI=10.1093/molbev/msi027;
Fischer A., Gilad Y., Man O., Paeaebo S.;
"Evolution of bitter taste receptors in humans and apes.";
Mol. Biol. Evol. 22:432-436(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-156.
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
CHARACTERIZATION.
PubMed=10761935; DOI=10.1016/S0092-8674(00)80706-0;
Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
Zuker C.S., Ryba N.J.P.;
"T2Rs function as bitter taste receptors.";
Cell 100:703-711(2000).
[6]
FUNCTION.
PubMed=15759003; DOI=10.1038/nature03352;
Mueller K.L., Hoon M.A., Erlenbach I., Chandrashekar J., Zuker C.S.,
Ryba N.J.;
"The receptors and coding logic for bitter taste.";
Nature 434:225-229(2005).
[7]
REVIEW.
PubMed=12139982; DOI=10.1016/S0959-4388(02)00345-8;
Montmayeur J.-P., Matsunami H.;
"Receptors for bitter and sweet taste.";
Curr. Opin. Neurobiol. 12:366-371(2002).
[8]
REVIEW.
PubMed=11696554; DOI=10.1074/jbc.R100054200;
Margolskee R.F.;
"Molecular mechanisms of bitter and sweet taste transduction.";
J. Biol. Chem. 277:1-4(2002).
[9]
REVIEW.
PubMed=12581520; DOI=10.1016/S0092-8674(03)00071-0;
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
Zuker C.S., Ryba N.J.;
"Coding of sweet, bitter, and umami tastes: different receptor cells
sharing similar signaling pathways.";
Cell 112:293-301(2003).
-!- FUNCTION: Gustducin-coupled strychnine receptor implicated in the
perception of bitter compounds in the oral cavity and the
gastrointestinal tract. Signals through PLCB2 and the calcium-
regulated cation channel TRPM5. {ECO:0000269|PubMed:15759003}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells
of the tongue and palate epithelium and exclusively in gustducin-
positive cells.
-!- MISCELLANEOUS: Several bitter taste receptors are expressed in a
single taste receptor cell.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF227136; AAF43909.1; -; Genomic_DNA.
EMBL; AY724946; AAU21148.1; -; Genomic_DNA.
EMBL; AC006518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC069089; AAH69089.1; -; mRNA.
EMBL; BC101762; AAI01763.1; -; mRNA.
EMBL; BC101764; AAI01765.1; -; mRNA.
CCDS; CCDS8634.1; -.
RefSeq; NP_076410.1; NM_023921.1.
UniGene; Hs.533756; -.
ProteinModelPortal; Q9NYW0; -.
IntAct; Q9NYW0; 2.
STRING; 9606.ENSP00000240619; -.
iPTMnet; Q9NYW0; -.
PhosphoSitePlus; Q9NYW0; -.
BioMuta; TAS2R10; -.
DMDM; 311033532; -.
PaxDb; Q9NYW0; -.
PeptideAtlas; Q9NYW0; -.
PRIDE; Q9NYW0; -.
Ensembl; ENST00000240619; ENSP00000240619; ENSG00000121318.
Ensembl; ENST00000576159; ENSP00000461683; ENSG00000272805.
Ensembl; ENST00000611256; ENSP00000482990; ENSG00000277238.
GeneID; 50839; -.
KEGG; hsa:50839; -.
UCSC; uc001qyy.2; human.
CTD; 50839; -.
DisGeNET; 50839; -.
EuPathDB; HostDB:ENSG00000121318.2; -.
GeneCards; TAS2R10; -.
HGNC; HGNC:14918; TAS2R10.
MIM; 604791; gene.
neXtProt; NX_Q9NYW0; -.
OpenTargets; ENSG00000121318; -.
PharmGKB; PA37928; -.
eggNOG; ENOG410IMNH; Eukaryota.
eggNOG; ENOG410Z4AM; LUCA.
GeneTree; ENSGT00760000119096; -.
HOGENOM; HOG000234595; -.
HOVERGEN; HBG060698; -.
InParanoid; Q9NYW0; -.
KO; K08474; -.
OMA; LIISLWR; -.
OrthoDB; EOG091G0KU9; -.
PhylomeDB; Q9NYW0; -.
TreeFam; TF335891; -.
Reactome; R-HSA-418594; G alpha (i) signalling events.
Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
GeneWiki; TAS2R10; -.
GenomeRNAi; 50839; -.
PRO; PR:Q9NYW0; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000121318; -.
CleanEx; HS_TAS2R10; -.
Genevisible; Q9NYW0; HS.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0033038; F:bitter taste receptor activity; IDA:UniProtKB.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.
InterPro; IPR007960; T2R.
PANTHER; PTHR11394; PTHR11394; 1.
Pfam; PF05296; TAS2R; 1.
1: Evidence at protein level;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Taste; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 307 Taste receptor type 2 member 10.
/FTId=PRO_0000082238.
TOPO_DOM 1 6 Extracellular. {ECO:0000255}.
TRANSMEM 7 27 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 28 42 Cytoplasmic. {ECO:0000255}.
TRANSMEM 43 63 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 64 100 Extracellular. {ECO:0000255}.
TRANSMEM 101 121 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 122 126 Cytoplasmic. {ECO:0000255}.
TRANSMEM 127 147 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 148 179 Extracellular. {ECO:0000255}.
TRANSMEM 180 200 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 201 227 Cytoplasmic. {ECO:0000255}.
TRANSMEM 228 248 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 249 257 Extracellular. {ECO:0000255}.
TRANSMEM 258 278 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 279 307 Cytoplasmic. {ECO:0000255}.
CARBOHYD 92 92 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 158 158 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 156 156 T -> M (in dbSNP:rs597468).
{ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:15496549}.
/FTId=VAR_030009.
SEQUENCE 307 AA; 35365 MW; 058DD69A55AE71C6 CRC64;
MLRVVEGIFI FVVVSESVFG VLGNGFIGLV NCIDCAKNKL STIGFILTGL AISRIFLIWI
IITDGFIQIF SPNIYASGNL IEYISYFWVI GNQSSMWFAT SLSIFYFLKI ANFSNYIFLW
LKSRTNMVLP FMIVFLLISS LLNFAYIAKI LNDYKTKNDT VWDLNMYKSE YFIKQILLNL
GVIFFFTLSL ITCIFLIISL WRHNRQMQSN VTGLRDSNTE AHVKAMKVLI SFIILFILYF
IGMAIEISCF TVRENKLLLM FGMTTTAIYP WGHSFILILG NSKLKQASLR VLQQLKCCEK
RKNLRVT


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