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Taste receptor type 2 member 14 (T2R14)

 T2R14_MACMU             Reviewed;         319 AA.
Q645T2;
23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
25-OCT-2004, sequence version 1.
05-JUL-2017, entry version 59.
RecName: Full=Taste receptor type 2 member 14;
Short=T2R14;
Name=TAS2R14;
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=15496549; DOI=10.1093/molbev/msi027;
Fischer A., Gilad Y., Man O., Paeaebo S.;
"Evolution of bitter taste receptors in humans and apes.";
Mol. Biol. Evol. 22:432-436(2005).
-!- FUNCTION: Receptor that may play a role in the perception of
bitterness and is gustducin-linked. May play a role in sensing the
chemical composition of the gastrointestinal content. The activity
of this receptor may stimulate alpha gustducin, mediate PLC-beta-2
activation and lead to the gating of TRPM5 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- MISCELLANEOUS: Most taste cells may be activated by a limited
number of bitter compounds; individual taste cells can
discriminate among bitter stimuli.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000305}.
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EMBL; AY725008; AAU21187.1; -; Genomic_DNA.
ProteinModelPortal; Q645T2; -.
eggNOG; ENOG410J9F7; Eukaryota.
eggNOG; ENOG4111BEG; LUCA.
HOGENOM; HOG000234595; -.
HOVERGEN; HBG060698; -.
InParanoid; Q645T2; -.
Proteomes; UP000006718; Unplaced.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
InterPro; IPR007960; T2R.
PANTHER; PTHR11394; PTHR11394; 1.
Pfam; PF05296; TAS2R; 1.
3: Inferred from homology;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 319 Taste receptor type 2 member 14.
/FTId=PRO_0000082256.
TOPO_DOM 1 7 Extracellular. {ECO:0000255}.
TRANSMEM 8 28 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 29 55 Cytoplasmic. {ECO:0000255}.
TRANSMEM 56 76 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 77 87 Extracellular. {ECO:0000255}.
TRANSMEM 88 108 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 109 129 Cytoplasmic. {ECO:0000255}.
TRANSMEM 130 150 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 151 184 Extracellular. {ECO:0000255}.
TRANSMEM 185 205 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 206 233 Cytoplasmic. {ECO:0000255}.
TRANSMEM 234 254 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 255 263 Extracellular. {ECO:0000255}.
TRANSMEM 264 284 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 285 319 Cytoplasmic. {ECO:0000255}.
CARBOHYD 153 153 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 162 162 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 319 AA; 36468 MW; 7EA3750E18F3C8F4 CRC64;
MDGVIKSIFT FILIVEFIIG NLGNSFIVLV NCIDWVKRRK ISLVDQILIA LAISRISLVW
SIFGSWCVSV FFPALFATEK LLRMLTNIWT VTNHFSVWLA TILGTFYFLK IANFSNSIFL
YLKWRVKKVV LVLLLVTLGL LFLNILLINI HINASINGYR GNMTCSSASC NFIRFSRAIA
LTSTVFVLIP FTLSLATSLL LSFSLWKHHK KMQHTVKGYR DVSTKAHRGV MQTVITFLLL
YAVFLLTFFI SIWASVRLKE NQIIILSEMM GLAYPSGHSC VLILGNKKLR QASLSVLWWL
RYRFKHGEPS GHKEFRESS


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