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Taste receptor type 2 member 16 (T2R16) (T2R18) (T2R3)

 T2R16_RAT               Reviewed;         299 AA.
Q9JKU0;
11-APR-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
22-NOV-2017, entry version 99.
RecName: Full=Taste receptor type 2 member 16;
Short=T2R16;
AltName: Full=T2R18;
AltName: Full=T2R3;
Name=Tas2r16; Synonyms=Tas2r18, Tas2r3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TOPOLOGY.
PubMed=10761934; DOI=10.1016/S0092-8674(00)80705-9;
Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
Zuker C.S.;
"A novel family of mammalian taste receptors.";
Cell 100:693-702(2000).
[2]
CHARACTERIZATION.
PubMed=10761935; DOI=10.1016/S0092-8674(00)80706-0;
Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
Zuker C.S., Ryba N.J.P.;
"T2Rs function as bitter taste receptors.";
Cell 100:703-711(2000).
[3]
TISSUE SPECIFICITY.
PubMed=11854532; DOI=10.1073/pnas.042617699;
Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J.,
Rozengurt E.;
"Expression of bitter taste receptors of the T2R family in the
gastrointestinal tract and enteroendocrine STC-1 cells.";
Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
[4]
REVIEW.
PubMed=12139982; DOI=10.1016/S0959-4388(02)00345-8;
Montmayeur J.-P., Matsunami H.;
"Receptors for bitter and sweet taste.";
Curr. Opin. Neurobiol. 12:366-371(2002).
[5]
REVIEW.
PubMed=11696554; DOI=10.1074/jbc.R100054200;
Margolskee R.F.;
"Molecular mechanisms of bitter and sweet taste transduction.";
J. Biol. Chem. 277:1-4(2002).
[6]
REVIEW.
PubMed=12581520; DOI=10.1016/S0092-8674(03)00071-0;
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
Zuker C.S., Ryba N.J.;
"Coding of sweet, bitter, and umami tastes: different receptor cells
sharing similar signaling pathways.";
Cell 112:293-301(2003).
-!- FUNCTION: Gustducin-coupled receptor implicated in the perception
of bitter compounds in the oral cavity and the gastrointestinal
tract. Signals through PLCB2 and the calcium-regulated cation
channel TRPM5.
-!- SUBUNIT: Interacts with RTP3 and RTP4.
{ECO:0000250|UniProtKB:Q9NYV7}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:Q9NYV7}; Multi-pass membrane protein
{ECO:0000255}.
-!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells
of the tongue and palate epithelium and exclusively in gustducin-
positive cells. Expressed in the antrum and fundus (part of the
stomach), duodenum and in gastric endocrine cells.
{ECO:0000269|PubMed:11854532}.
-!- MISCELLANEOUS: Several bitter taste receptors are expressed in a
single taste receptor cell.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF227141; AAF43914.1; -; mRNA.
RefSeq; NP_076484.1; NM_023994.1.
UniGene; Rn.48783; -.
STRING; 10116.ENSRNOP00000031530; -.
PhosphoSitePlus; Q9JKU0; -.
PaxDb; Q9JKU0; -.
PRIDE; Q9JKU0; -.
Ensembl; ENSRNOT00000034936; ENSRNOP00000031530; ENSRNOG00000021799.
GeneID; 78980; -.
KEGG; rno:78980; -.
UCSC; RGD:620735; rat.
CTD; 387347; -.
RGD; 620735; Tas2r16.
eggNOG; ENOG410IKNW; Eukaryota.
eggNOG; ENOG41119UD; LUCA.
GeneTree; ENSGT00760000119096; -.
HOGENOM; HOG000234595; -.
HOVERGEN; HBG098568; -.
InParanoid; Q9JKU0; -.
KO; K08474; -.
OMA; CVTIIPS; -.
OrthoDB; EOG091G0HIR; -.
PhylomeDB; Q9JKU0; -.
TreeFam; TF335891; -.
Reactome; R-RNO-418594; G alpha (i) signalling events.
Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
PRO; PR:Q9JKU0; -.
Proteomes; UP000002494; Chromosome 4.
Genevisible; Q9JKU0; RN.
GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005802; C:trans-Golgi network; ISO:RGD.
GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
InterPro; IPR007960; T2R.
PANTHER; PTHR11394; PTHR11394; 1.
Pfam; PF05296; TAS2R; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; G-protein coupled receptor;
Glycoprotein; Membrane; Receptor; Reference proteome;
Sensory transduction; Taste; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 299 Taste receptor type 2 member 16.
/FTId=PRO_0000082268.
TOPO_DOM 1 5 Extracellular. {ECO:0000255}.
TRANSMEM 6 26 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 27 44 Cytoplasmic. {ECO:0000255}.
TRANSMEM 45 65 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 66 82 Extracellular. {ECO:0000255}.
TRANSMEM 83 103 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 104 125 Cytoplasmic. {ECO:0000255}.
TRANSMEM 126 146 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 147 183 Extracellular. {ECO:0000255}.
TRANSMEM 184 204 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 205 233 Cytoplasmic. {ECO:0000255}.
TRANSMEM 234 254 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 255 258 Extracellular. {ECO:0000255}.
TRANSMEM 259 279 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 280 299 Cytoplasmic. {ECO:0000255}.
CARBOHYD 163 163 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 299 AA; 34642 MW; ECDC2EBB29943B6E CRC64;
MVPTQVTIFS IIMYVLESLV IIVQSCTTVA VLFREWMHFQ RLSPVEIILI SLGISHFCLQ
WTSMLYNFGT YSRPVLLFWK VSVVWEFMNV LTFWLTSLLA VLYCVKVSSF SHPVFLWLRL
KILKLVLWLL LGALIASCLS IIPSVVKYHI QMELLTLDHL PKNSSLILRL QMFEWYFSNP
FKMIGFGVPF LVFLISIILL TVSLVQHWGQ MKHYSSSSSS LRAQCTVLKS LATFFIFFTS
YFLTIVVSFI GTVFDKKSWF WVCEAVIYGL VCIHFTSLMM SNPTLKKALR LQFWSPESS


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