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Taste receptor type 2 member 31 (T2R31) (Taste receptor type 2 member 44) (T2R44) (Taste receptor type 2 member 53) (T2R53)

 T2R31_HUMAN             Reviewed;         309 AA.
P59538; P59547; Q17R84; Q645X5;
11-APR-2003, integrated into UniProtKB/Swiss-Prot.
28-JUN-2011, sequence version 2.
27-SEP-2017, entry version 116.
RecName: Full=Taste receptor type 2 member 31;
Short=T2R31;
AltName: Full=Taste receptor type 2 member 44;
Short=T2R44;
AltName: Full=Taste receptor type 2 member 53;
Short=T2R53;
Name=TAS2R31; Synonyms=TAS2R44;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT MET-162.
PubMed=12379855; DOI=10.1038/ng1014;
Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.;
"The human TAS2R16 receptor mediates bitter taste in response to beta-
glucopyranosides.";
Nat. Genet. 32:397-401(2002).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12584440; DOI=10.1159/000068546;
Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
"Identification and characterization of human taste receptor genes
belonging to the TAS2R family.";
Cytogenet. Genome Res. 98:45-53(2002).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-162; VAL-227 AND
ILE-240.
PubMed=15496549; DOI=10.1093/molbev/msi027;
Fischer A., Gilad Y., Man O., Paeaebo S.;
"Evolution of bitter taste receptors in humans and apes.";
Mol. Biol. Evol. 22:432-436(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
REVIEW.
PubMed=12139982; DOI=10.1016/S0959-4388(02)00345-8;
Montmayeur J.-P., Matsunami H.;
"Receptors for bitter and sweet taste.";
Curr. Opin. Neurobiol. 12:366-371(2002).
[7]
REVIEW.
PubMed=11696554; DOI=10.1074/jbc.R100054200;
Margolskee R.F.;
"Molecular mechanisms of bitter and sweet taste transduction.";
J. Biol. Chem. 277:1-4(2002).
[8]
REVIEW.
PubMed=12581520; DOI=10.1016/S0092-8674(03)00071-0;
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
Zuker C.S., Ryba N.J.;
"Coding of sweet, bitter, and umami tastes: different receptor cells
sharing similar signaling pathways.";
Cell 112:293-301(2003).
[9]
ACTIVATION BY SACCHARIN AND ACESULFAME K.
PubMed=15537898; DOI=10.1523/JNEUROSCI.1225-04.2004;
Kuhn C., Bufe B., Winnig M., Hofmann T., Frank O., Behrens M.,
Lewtschenko T., Slack J.P., Ward C.D., Meyerhof W.;
"Bitter taste receptors for saccharin and acesulfame K.";
J. Neurosci. 24:10260-10265(2004).
-!- FUNCTION: Receptor that may play a role in the perception of
bitterness and is gustducin-linked. May play a role in sensing the
chemical composition of the gastrointestinal content. The activity
of this receptor may stimulate alpha gustducin, mediate PLC-beta-2
activation and lead to the gating of TRPM5 (By similarity).
Activated by the sulfonyl amide sweeteners saccharin and
acesulfame K. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells
of the tongue and exclusively in gustducin-positive cells.
-!- MISCELLANEOUS: Most taste cells may be activated by a limited
number of bitter compounds; individual taste cells can
discriminate among bitter stimuli.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF494228; AAM19319.1; -; Genomic_DNA.
EMBL; AY114090; AAM63540.1; -; Genomic_DNA.
EMBL; AY724942; AAU21144.1; -; Genomic_DNA.
EMBL; AC018630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC117421; AAI17422.1; -; mRNA.
CCDS; CCDS53747.1; -.
RefSeq; NP_795366.2; NM_176885.2.
UniGene; Hs.688197; -.
ProteinModelPortal; P59538; -.
STRING; 9606.ENSP00000375093; -.
BindingDB; P59538; -.
ChEMBL; CHEMBL2034804; -.
GuidetoPHARMACOLOGY; 674; -.
iPTMnet; P59538; -.
PhosphoSitePlus; P59538; -.
BioMuta; TAS2R31; -.
DMDM; 338817946; -.
PaxDb; P59538; -.
PeptideAtlas; P59538; -.
PRIDE; P59538; -.
DNASU; 259290; -.
Ensembl; ENST00000390675; ENSP00000375093; ENSG00000256436.
Ensembl; ENST00000572376; ENSP00000459810; ENSG00000263097.
GeneID; 259290; -.
KEGG; hsa:259290; -.
UCSC; uc001qzo.1; human.
CTD; 259290; -.
EuPathDB; HostDB:ENSG00000256436.1; -.
GeneCards; TAS2R31; -.
HGNC; HGNC:19113; TAS2R31.
MIM; 612669; gene.
neXtProt; NX_P59538; -.
OpenTargets; ENSG00000256436; -.
eggNOG; ENOG410J9F7; Eukaryota.
eggNOG; ENOG4111BEG; LUCA.
GeneTree; ENSGT00760000119096; -.
InParanoid; P59538; -.
KO; K08474; -.
OMA; VINMKEI; -.
OrthoDB; EOG091G0HMB; -.
PhylomeDB; P59538; -.
TreeFam; TF335891; -.
Reactome; R-HSA-418594; G alpha (i) signalling events.
Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
GeneWiki; TAS2R31; -.
GenomeRNAi; 259290; -.
PRO; PR:P59538; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000256436; -.
CleanEx; HS_TAS2R44; -.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0033038; F:bitter taste receptor activity; IDA:UniProtKB.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.
InterPro; IPR007960; T2R.
PANTHER; PTHR11394; PTHR11394; 1.
Pfam; PF05296; TAS2R; 1.
2: Evidence at transcript level;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Taste; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 309 Taste receptor type 2 member 31.
/FTId=PRO_0000082309.
TOPO_DOM 1 2 Extracellular. {ECO:0000255}.
TRANSMEM 3 23 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 24 55 Cytoplasmic. {ECO:0000255}.
TRANSMEM 56 76 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 77 100 Extracellular. {ECO:0000255}.
TRANSMEM 101 121 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 122 126 Cytoplasmic. {ECO:0000255}.
TRANSMEM 127 147 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 148 181 Extracellular. {ECO:0000255}.
TRANSMEM 182 202 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 203 229 Cytoplasmic. {ECO:0000255}.
TRANSMEM 230 250 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 251 259 Extracellular. {ECO:0000255}.
TRANSMEM 260 280 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 281 309 Cytoplasmic. {ECO:0000255}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 35 35 R -> W (in dbSNP:rs10845295).
/FTId=VAR_030684.
VARIANT 162 162 L -> M (in dbSNP:rs10743938).
{ECO:0000269|PubMed:12379855,
ECO:0000269|PubMed:15496549}.
/FTId=VAR_030685.
VARIANT 217 217 Q -> E (in dbSNP:rs10845294).
/FTId=VAR_030686.
VARIANT 227 227 A -> V (in dbSNP:rs10845293).
{ECO:0000269|PubMed:15496549}.
/FTId=VAR_030687.
VARIANT 240 240 V -> I (in dbSNP:rs10772423).
{ECO:0000269|PubMed:15496549}.
/FTId=VAR_030688.
VARIANT 276 276 P -> R (in dbSNP:rs12318612).
/FTId=VAR_062090.
SEQUENCE 309 AA; 35278 MW; 56926C025E4C6358 CRC64;
MTTFIPIIFS SVVVVLFVIG NFANGFIALV NSIERVKRQK ISFADQILTA LAVSRVGLLW
VLLLNWYSTV FNPAFYSVEV RTTAYNVWAV TGHFSNWLAT SLSIFYLLKI ANFSNLIFLH
LKRRVKSVIL VMLLGPLLFL ACQLFVINMK EIVRTKEYEG NLTWKIKLRS AVYLSDATVT
TLGNLVPFTL TLLCFLLLIC SLCKHLKKMQ LHGKGSQDPS TKVHIKALQT VIFFLLLCAV
YFLSIMISVW SFGSLENKPV FMFCKAIRFS YPSIHPFILI WGNKKLKQTF LSVLRQVRYW
VKGEKPSSP


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