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Taste receptor type 2 member 38 (T2R38) (T2R138) (mT2R31)

 T2R38_MOUSE             Reviewed;         331 AA.
Q7TQA6; A0PK79; Q4VHF0;
16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
25-OCT-2017, entry version 96.
RecName: Full=Taste receptor type 2 member 38;
Short=T2R38;
AltName: Full=T2R138;
AltName: Full=mT2R31;
Name=Tas2r38; Synonyms=T2r31, Tas2r138;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP40339.1};
[1] {ECO:0000312|EMBL:AAP40339.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP40339.1};
PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
"Evolutionary relationships of the Tas2r receptor gene families in
mouse and human.";
Physiol. Genomics 14:73-82(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=C57BL/6J;
PubMed=15886333; DOI=10.1152/physiolgenomics.00030.2005;
Wu S.V., Chen M.C., Rozengurt E.;
"Genomic organization, expression, and function of bitter taste
receptors (T2R) in mouse and rat.";
Physiol. Genomics 22:139-149(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5] {ECO:0000305}
IDENTIFICATION.
PubMed=12679530; DOI=10.1093/molbev/msg083;
Shi P., Zhang J., Yang H., Zhang Y.-P.;
"Adaptive diversification of bitter taste receptor genes in mammalian
evolution.";
Mol. Biol. Evol. 20:805-814(2003).
-!- FUNCTION: Putative taste receptor which may play a role in the
perception of bitterness. {ECO:0000303|PubMed:12734386}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Low levels in tongue, stomach and duodenum.
{ECO:0000269|PubMed:15886333}.
-!- MISCELLANEOUS: Several bitter taste receptors are expressed in a
single taste receptor cell.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF532789; AAP40339.1; -; Genomic_DNA.
EMBL; AY916509; AAX99132.1; -; mRNA.
EMBL; AC153378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC128016; AAI28017.1; -; mRNA.
EMBL; BK001093; DAA01232.1; -; Genomic_DNA.
CCDS; CCDS20038.1; -.
RefSeq; NP_001001451.1; NM_001001451.1.
UniGene; Mm.377920; -.
ProteinModelPortal; Q7TQA6; -.
STRING; 10090.ENSMUSP00000075876; -.
PhosphoSitePlus; Q7TQA6; -.
PaxDb; Q7TQA6; -.
PRIDE; Q7TQA6; -.
Ensembl; ENSMUST00000076565; ENSMUSP00000075876; ENSMUSG00000058250.
GeneID; 387513; -.
KEGG; mmu:387513; -.
UCSC; uc009bne.1; mouse.
CTD; 387513; -.
MGI; MGI:2681306; Tas2r138.
eggNOG; ENOG410IH9N; Eukaryota.
eggNOG; ENOG410Z3YE; LUCA.
GeneTree; ENSGT00760000119096; -.
HOGENOM; HOG000041379; -.
HOVERGEN; HBG098741; -.
InParanoid; Q7TQA6; -.
KO; K08474; -.
OMA; AACPSGH; -.
OrthoDB; EOG091G0ERQ; -.
PhylomeDB; Q7TQA6; -.
TreeFam; TF335891; -.
Reactome; R-MMU-418594; G alpha (i) signalling events.
Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
PRO; PR:Q7TQA6; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000058250; -.
CleanEx; MM_TAS2R138; -.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
CDD; cd15025; 7tm_TAS2R38; 1.
InterPro; IPR007960; T2R.
InterPro; IPR030050; TAS2R38.
PANTHER; PTHR11394; PTHR11394; 1.
PANTHER; PTHR11394:SF52; PTHR11394:SF52; 1.
Pfam; PF05296; TAS2R; 1.
2: Evidence at transcript level;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 331 Taste receptor type 2 member 38.
/FTId=PRO_0000082279.
TOPO_DOM 1 17 Extracellular. {ECO:0000255}.
TRANSMEM 18 38 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 39 55 Cytoplasmic. {ECO:0000255}.
TRANSMEM 56 76 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 77 94 Extracellular. {ECO:0000255}.
TRANSMEM 95 115 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 116 142 Cytoplasmic. {ECO:0000255}.
TRANSMEM 143 163 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 164 189 Extracellular. {ECO:0000255}.
TRANSMEM 190 210 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 211 243 Cytoplasmic. {ECO:0000255}.
TRANSMEM 244 264 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 265 276 Extracellular. {ECO:0000255}.
TRANSMEM 277 297 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 298 331 Cytoplasmic. {ECO:0000255}.
CARBOHYD 177 177 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 331 AA; 36966 MW; 37A9B6D0885BF9C0 CRC64;
MLSLTPVLTV SYEAKISFLF LSAMEFAVGI LANAFIVLVN VWDVVKKQPL NNCDIALLCL
SITRLFLQGL LLLDAIQLAC FQQMKDPLSH NYQAILTLWM IANQVSLWLA ACLSLLYCSK
IVRFSHTFPL HVASWVSRRF LQMLLVVLLL SCICTALCLW DFFCRSHSTV TSLLHLNSTE
FSLQIAKLNF FYSFIFCNVG SVPPSLAFLV SSGVLVISLG SHMRTMKSQT SSSGDPSLEA
HIRAIIFLIS FFCFYVVSFC AALISIPLLM LWHNKGGVMI CIGMMAACPS GHAAILISGN
AKLRRAIETM LFWFQSRQKV RPVHKVPPRT L


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